scholarly journals Theragnostic Aspects and Radioimmunotherapy in Pediatric Tumors

2020 ◽  
Vol 21 (11) ◽  
pp. 3849 ◽  
Author(s):  
Andrea Cimini ◽  
Maria Ricci ◽  
Agostino Chiaravalloti ◽  
Luca Filippi ◽  
Orazio Schillaci
Keyword(s):  
Nuclear Medicine ◽  
Brain Tumors ◽  
Pediatric Oncology ◽  
Potential Role ◽  
Pediatric Tumors ◽  
Web Based ◽  
Literature Research ◽  
Preliminary Results ◽  
Personal Approach

The use of theragnostic radiopharmaceuticals in nuclear medicine has grown rapidly over the years to combine the diagnosis and therapy of tumors. In this review, we performed web-based and desktop literature research to investigate and explain the potential role of theragnostic imaging in pediatric oncology. We focused primarily on patients with aggressive malignancies such as neuroblastoma and brain tumors, to select patients with the highest chance of benefit from personalized therapy. Moreover, the most critical and groundbreaking applications of radioimmunotherapy in children’s oncology were examined in this peculiar context. Preliminary results showed the potential feasibility of theragnostic imaging and radioimmunotherapy in pediatric oncology. They revealed advantages in the management of the disease, thereby allowing an intra-personal approach and adding new weapons to conventional therapies.

scholarly journals The potential role of MR-guided adaptive radiotherapy in pediatric oncology: results from a SIOPE-COG survey

2021 ◽  
Author(s):  
Enrica Seravalli ◽  
Petra S. Kroon ◽  
John M. Buatti ◽  
Matthew D. Hall ◽  
Henry C. Mandeville ◽  
...  
Keyword(s):  
Pediatric Oncology ◽  
Potential Role ◽  
Adaptive Radiotherapy

scholarly journals EPT-11THE POTENTIAL ROLE OF REGADENOSON TO TRANSIENTLY DISRUPT THE BLOOD-BRAIN BARRIER AND IMPROVE TEMOZOLOMIDE DELIVERY TO BRAIN TUMORS

2016 ◽  
Vol 18 (suppl 3) ◽  
pp. iii26.1-iii26
Author(s):  
Sadhana Jackson ◽  
Anna Piotrowski ◽  
Jon Weingart ◽  
Thura Abd ◽  
Richard George ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Blood Brain Barrier ◽  
Potential Role ◽  
Brain Barrier ◽  
Blood Brain

scholarly journals Risk of Brain Tumors in Children and Susceptibility to Organophosphorus Insecticides: The Potential Role of Paraoxonase (PON1)

2005 ◽  
Vol 113 (7) ◽  
pp. 909-913 ◽  
Author(s):  
Susan Searles Nielsen ◽  
Beth A. Mueller ◽  
Anneclaire J. De Roos ◽  
Hannah-Malia A. Viernes ◽  
Federico M. Farin ◽  
...  
Keyword(s):  
Brain Tumors ◽  
Potential Role ◽  
Organophosphorus Insecticides

scholarly journals The Relationship Between Gratitude and Loneliness: The Potential Benefits of Gratitude for Promoting Social Bonds

2015 ◽  
Vol 11 (2) ◽  
pp. 323-334 ◽  
Author(s):  
Andrea Caputo
Keyword(s):  
Potential Role ◽  
Well Being ◽  
Online Questionnaire ◽  
Convenience Sample ◽  
Web Based ◽  
Factors Affecting ◽  
Total Variability ◽  
Potential Benefits ◽  
The Relationship

This paper explores the potential role of gratitude on the reduction of loneliness feelings, even controlling for several variables related to social desirability, well-being (subjective happiness and life satisfaction) and socio-demographic characteristics. Through a web-based survey a convenience sample of 197 participants completed an online questionnaire including these measures. Correlation analyses and four-step hierarchical multiple regression analyses were conducted. The results show a negative correlation between gratitude and loneliness; specifically, gratitude succeeds in accounting for up to almost one-fifth of the total variability of loneliness even controlling for further variables. Being female, not having a stable and consolidated relationship and not participating in the labor force represent some risk factors affecting loneliness which should be taken into account in further research.

scholarly journals Designing a New Molecular Probe: The Potential Role for Tilmanocept (Lymphoseek®) in the Assessment of Patients with Painful Hip and Knee Joint Prostheses

2017 ◽  
Vol 11 (1) ◽  
pp. 212-224 ◽  
Author(s):  
O.O. Adesanya ◽  
C.E. Hutchinson
Keyword(s):  
Computed Tomography ◽  
Nuclear Medicine ◽  
Potential Role ◽  
Molecular Probe ◽  
Emission Computed Tomography ◽  
Joint Prosthesis ◽  
Prosthetic Joints ◽  
Pet Ct ◽  
Joint Prostheses

Background:There is a long history of nuclear medicine developments in orthopaedics beginning in the early 20thcentury. Technetium-99m (99mTc) has a short half-life of six hours, emits 140 keV gamma rays and is the most widely used isotope, imaged with the Anger (gamma) camera. Gamma image quality and test sensitivity in painful prosthetic joints can be improved with single photon emission computed tomography (SPECT) and SPECT/CT. Positron Emission Tomography-Computed Tomography (PET-CT) with Sodium Fluoride (18F-NaF) and18Fluorine-fluorodeoxyglucose (18F-FDG) PET have promising and limited roles respectively in the investigation of painful prosthetic joints. New SPECT/CT and PET-CT isotopes targeting activated macrophages with99mTc Tilmanocept (Lymphoseek®) and68Gallium labelled Tilmanocept respectively show potential as agents to demonstrate wear particles ingested by macrophages and multinucleated giant cells. An imaging algorithm using SPECT and/or PET agents is proffered as a cost effective way of speedily and accurately arriving a diagnosis.Methods:Review of the historical role of nuclear medicine in orthopaedics and research into the potential role of new radiopharmaceutical agents was undertaken. Guidelines and algorithms for the imaging of complicated joint prosthesis are provided.Results:There is an established role for nuclear medicine in orthopaedics and particularly in the investigation of complicated joint prostheses. Imaging with Tilmanocept provides new opportunities to shorten the time to diagnose loosened and infected joint prostheses.Conclusion:There is a potential new role for Tilmanocept, which can be utilised with both PET-CT and SPECT-CT technologies. Tilmanocept is a relatively new radiopharmaceutical which has a potential role in the imaging assessment of painful joint prosthesis.

scholarly journals PATH-55. THE POTENTIAL ROLE OF ERCC1 AS A BIOMARKER FOR PLATINUM BASED THERAPY IN PRIMARY AND METASTATIC BRAIN TUMORS

2017 ◽  
Vol 19 (suppl_6) ◽  
pp. vi183-vi183
Author(s):  
Lyndon Kim ◽  
Kevin Judy ◽  
Christopher Farrell ◽  
James Evans ◽  
David Andrews
Keyword(s):  
Brain Tumors ◽  
Potential Role ◽  
Metastatic Brain Tumors
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