scholarly journals Molecular Alterations in Gastric Preneoplastic Lesions and Early Gastric Cancer

2021 ◽  
Vol 22 (13) ◽  
pp. 6652
Author(s):  
Serena Battista ◽  
Maria Raffaella Ambrosio ◽  
Francesco Limarzi ◽  
Graziana Gallo ◽  
Luca Saragoni
Keyword(s):  
Gastric Cancer ◽  
Molecular Markers ◽  
Early Gastric Cancer ◽  
Signet Ring Cell ◽  
Preneoplastic Lesions ◽  
Molecular Alterations ◽  
Gastric Dysplasia ◽  
Signet Ring ◽  
Ring Cell

Prognosis of gastric cancer is dramatically improved by early diagnosis. Correa’s cascade correlates the expression of some molecular markers with the progression of preneoplastic lesions toward carcinoma. This article reviews the diagnostic and prognostic values of molecular markers in complete (MUC2) and incomplete (MUC2, MUC5AC, and MUC6) intestinal metaplasia, gastric dysplasia/intra-epithelial neoplasia, and early gastric cancer. In particular, considering preinvasive neoplasia and early gastric cancer, some studies have demonstrated a correlation between molecular alterations and prognosis, for example, mucins phenotype in gastric dysplasia, and GATA6, TP53 mutation/LOH and MUC6 in early gastric cancer. Moreover, this review considers novelties from the literature regarding the (immuno)histochemical characterization of diffuse-type/signet ring cell gastric cancer, with particular attention to clinical outcomes of patients. The aim of this review is the evaluation of the state of the art regarding suitable biomarkers used in the pre-surgical phase, which can distinguish patients with different prognoses and help decide the best therapeutic strategy.

Risk Factors for Lymph Node Metastasis in Early Gastric Cancer with Signet Ring Cell Carcinoma

2015 ◽  
Vol 19 (11) ◽  
pp. 1958-1965 ◽  
Author(s):  
Chun Guang Guo ◽  
Dong Bing Zhao ◽  
Qian Liu ◽  
Zhi Xiang Zhou ◽  
Ping Zhao ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Node Metastasis ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Early Gastric Cancer with Signet Ring Cell Histology Remained Unresected for 53 Months

2011 ◽  
Vol 11 (3) ◽  
pp. 189 ◽  
Author(s):  
Seung Soo Lee ◽  
Seung Wan Ryu ◽  
In Ho Kim ◽  
Soo Sang Sohn
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Establishment and characterization of GCSR1, a multi-drug resistant signet ring cell gastric cancer cell line

2015 ◽  
Vol 46 (6) ◽  
pp. 2479-2487 ◽  
Author(s):  
XIN XU ◽  
LI-JUAN QIAN ◽  
XING-YUN SU ◽  
KUI-FENG HE ◽  
KE-TAO JIN ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cell Line ◽  
Gastric Cancer Cell ◽  
Gastric Cancer Cell Line ◽  
Cancer Cell Line ◽  
Signet Ring Cell ◽  
Drug Resistant ◽  
Signet Ring ◽  
Ring Cell

scholarly journals Signet ring cell carcinoma of early gastric cancer, is endoscopic treatment really risky?

Medicine ◽  
2017 ◽  
Vol 96 (33) ◽  
pp. e7532 ◽  
Author(s):  
Sun Hyung Kang ◽  
Joo Seok Kim ◽  
Hee Seok Moon ◽  
Eaum Seok Lee ◽  
Seok Hyun Kim ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Early Gastric Cancer ◽  
Cell Carcinoma ◽  
Endoscopic Treatment ◽  
Signet Ring Cell Carcinoma ◽  
Signet Ring Cell ◽  
Signet Ring ◽  
Ring Cell

Early gastric cancer with signet-ring cell histologic type: Risk factors of lymph node metastasis and indications of endoscopic surgery

Surgery ◽  
2011 ◽  
Vol 149 (3) ◽  
pp. 356-363 ◽  
Author(s):  
Jian-hua Tong ◽  
Zhe Sun ◽  
Zhen-ning Wang ◽  
Yan-hui Zhao ◽  
Bao-jun Huang ◽  
...  
Keyword(s):  
Risk Factors ◽  
Gastric Cancer ◽  
Lymph Node ◽  
Lymph Node Metastasis ◽  
Early Gastric Cancer ◽  
Signet Ring Cell ◽  
Histologic Type ◽  
Node Metastasis ◽  
Signet Ring ◽  
Ring Cell
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