Ectopic Fat Accumulation in Pancreas and Heart

Ectopic fat is found in liver, muscle, and kidney and is known to accumulate as visceral fat. In recent years, ectopic fat has also been observed in the pancreas, and it has been said that pancreatic fat accumulation is related to the pathophysiology of diabetes and the onset of diabetes, but the relationship has not yet been determined. In the heart, epicardium fat is another ectopic fat, which is associated with the development of coronary artery disease. Ectopic fat is also observed in the myocardium, and diabetic patients have more fat accumulation in this tissue than nondiabetic patients. Myocardium fat is reported to be related to diastolic cardiac dysfunction, which is one of the characteristics of the complications observed in diabetic patients. We recently reported that ectopic fat accumulation was observed in coronary arteries of a type 2 diabetic patient with intractable coronary artery disease, and coronary artery is attracting attention as a new tissue of ectopic fat accumulation. Here, we summarize the latest findings focusing on the relationship between ectopic fat accumulation in these organs and diabetic pathophysiology and complications, then describe the possibility of future treatments targeting these ectopic fat accumulations.

Download Full-text

Evaluation of aortic arch calcification in type 2 diabetic patients

VASA ◽

10.1024/0301-1526.34.2.113 ◽

2005 ◽

Vol 34 (2) ◽

pp. 113-117 ◽

Cited By ~ 4

Author(s):

Papanas ◽

Symeonidis ◽

Maltezos ◽

Giannakis ◽

Mavridis ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Aortic Arch ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Insulin Dependence ◽

Artery Disease ◽

Type 2 Diabetic ◽

Aortic Arch Calcification

Background: The purpose of this study is to evaluate the severity of aortic arch calcification among type 2 diabetic patients in association with diabetes duration, diabetic complications, coronary artery disease and presence of cardiovascular risk factors. Patients and methods: This study included 207 type 2 diabetic patients (101 men) with a mean age of 61.5 ± 8.1 years and a mean diabetes duration of 13.9 ± 6.4 years. Aortic arch calcification was assessed by means of posteroanterior chest X-rays. Severity of calcification was graded as follows: grade 0 (no visible calcification), grade 1 (small spots of calcification or single thin calcification of the aortic knob), grade 2 (one or more areas of thick calcification), grade 3 (circular calcification of the aortic knob). Results: Severity of calcification was grade 0 in 84 patients (40.58%), grade 1 in 64 patients (30.92%), grade 2 in 43 patients (20.77%) and grade 3 in 16 patients (7.73%). In simple regression analysis severity of aortic arch calcification was associated with age (p = 0.032), duration of diabetes (p = 0.026), insulin dependence (p = 0.042) and presence of coronary artery disease (p = 0.039), hypertension (p = 0.019), dyslipidaemia (p = 0.029), retinopathy (p = 0.012) and microalbuminuria (p = 0.01). In multiple regression analysis severity of aortic arch calcification was associated with age (p = 0.04), duration of diabetes (p = 0.032) and presence of hypertension (p = 0.024), dyslipidaemia (p = 0.031) and coronary artery disease (p = 0.04), while the association with retinopathy, microalbuminuria and insulin dependence was no longer significant. Conclusions: Severity of aortic arch calcification is associated with age, diabetes duration, diabetic complications (retinopathy, microalbuminuria), coronary artery disease, insulin dependence, and presence of hypertension and dyslipidaemia.

Download Full-text

Evaluation of Malondialdehyde (MDA) in type 2 diabetic Patients with Coronary Artery Disease (CAD)

Journal of Biology and Today s World ◽

10.15412/j.jbtw.01030602 ◽

2014 ◽

Vol 3 (6) ◽

Cited By ~ 1

Author(s):

J. Zavar-Reza ◽

H. Shahmoradi ◽

A. Mohammadyari ◽

M. Mohammadbeigi ◽

R. Hosseini ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic

Download Full-text

1425-P: White Blood Cell Count Predicts Cardiovascular Prognosis in Type 2 Diabetic Patients with Established Coronary Artery Disease

Diabetes ◽

10.2337/db20-1425-p ◽

2020 ◽

Vol 69 (Supplement 1) ◽

pp. 1425-P

Author(s):

ATSUHIKO KAWABE ◽

YUKI NAKATANI ◽

SHOYA ONO ◽

YASUSHI MIYASHITA ◽

MIHOKO MATSUMURA ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetic Patients ◽

Blood Cell Count ◽

Type 2 Diabetic Patients ◽

Established Coronary Artery Disease ◽

Cardiovascular Prognosis ◽

Artery Disease ◽

Type 2 Diabetic

Download Full-text

Association of Plasma Myeloperoxidase Level with Risk of Coronary Artery Disease in Patients with Type 2 Diabetes

Disease Markers ◽

10.1155/2015/761939 ◽

2015 ◽

Vol 2015 ◽

pp. 1-5 ◽

Cited By ~ 8

Author(s):

Ping Song ◽

Jin Xu ◽

Yongfeng Song ◽

Shiliang Jiang ◽

Haitao Yuan ◽

...

Keyword(s):

Type 2 Diabetes ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Linear Regression Analysis ◽

Multiple Linear Regression Analysis ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Logistic Analysis ◽

Artery Disease

Aims. This study aimed to investigate whether the change of plasma myeloperoxidase (MPO) level would be associated with the incidence of coronary artery disease (CAD) among diabetic patients.Methods. 339 patients with type 2 diabetes mellitus (DM) underwent coronary angiography. Of them, 204 cases had CAD and were assigned to CAD group and 135 cases without CAD were assigned to non-CAD group.Results. Compared to non-CAD group, CAD group had higher level of plasma MPO (p<0.01). Multiple linear regression analysis showed that plasma MPO level was correlated with Gensini score. Multiple logistic analysis showed that the odds ratios for CAD across increasing tertiles of MPO level were 1.191 (0.971–1.547) and 1.488 (1.115–2.228) (p=0.048,p=0.009versus 1st tertile of MPO level, resp.) by adjusting for age, sex, and other conventional risk factors for CAD. The subjects were stratified into nine groups according to tertiles of MPO and HbA1c. The odds ratio for CAD was significantly higher in group with highest levels of MPO and HbA1c (OR = 4.08,p<0.01).Conclusion. Plasma MPO level was positively correlated with the degree of coronary artery stenosis in type 2 diabetic patients, and increasing blood glucose might amplify the association between MPO and CAD.

Download Full-text

Cystatin C Versus Creatinine- Based Definition of Renal Dysfunction for Predicting Poor Coronary Collateralization in Type 2 Diabetic Patients with Stable Coronary Artery Disease

Journal of Diabetes & Metabolism ◽

10.4172/2155-6156.1000453 ◽

2014 ◽

Vol 5 (11) ◽

Author(s):

Ying Shen Feng Hua Ding

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Renal Dysfunction ◽

Stable Coronary Artery Disease ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Definition Of ◽

Type 2 Diabetic

Download Full-text

Revascularization for Advanced Coronary Artery Disease in Type 2 Diabetic Patients: Choosing Wisely Between PCI and Surgery

Current Cardiology Reports ◽

10.1007/s11886-017-0849-7 ◽

2017 ◽

Vol 19 (5) ◽

Author(s):

Louai Razzouk ◽

Frederick Feit ◽

Michael E. Farkouh

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Choosing Wisely ◽

Diabetic Patients ◽

Type 2 Diabetic Patients ◽

Artery Disease ◽

Type 2 Diabetic ◽

Advanced Coronary Artery Disease

Download Full-text

Utility of Platelet Indices in Assessing the Risk of Coronary Artery Disease in Patients of Diabetes Mellitus

10.21203/rs.3.rs-62409/v1 ◽

2020 ◽

Author(s):

Ayesh Khatoon ◽

Shakti Kumar Yadav ◽

Sompal Singh ◽

Harsh Vardhan Singh ◽

Namrata Sarin

Keyword(s):

Diabetes Mellitus ◽

Coronary Artery Disease ◽

Coronary Artery ◽

Diabetic Patients ◽

Platelet Volume ◽

Distribution Width ◽

Type 2 Dm ◽

Significant Difference ◽

Artery Disease

Abstract Background: Platelet volume indices (PVI) such as mean platelet volume (MPV), platelet distribution width (PDW) and platelet large cell ratio (P-LCR), are the indicators of increased platelet activity which may play a role in development of vascular complications in diabetic patients. This study was performed to evaluate and compare the platelet volume indices such as MPV, PDW, P-LCR in patients of type 2 diabetes mellitus (DM) with and without manifested coronary artery disease in order to identify their usefulness in determining the risk for development of coronary complications.Methods: Analytical cross - sectional study included 150 patients of which 100 patients were diagnosed as type 2 DM and 50 apparently healthy controls. The study cases were divided into two groups based on presence or absence of coronary artery disease. Group A included 50 cases of type 2 DM without manifested coronary artery disease and group B included 50 cases of type 2 DM with manifested coronary artery disease. PVI was obtained using automated cell counter.Results: MPV, PDW, P-LCR were significantly higher in diabetics as compared to controls subjects (P < 0.001 for all). However, no statistically significant difference was found between diabetics with and without manifested coronary artery disease.Conclusions: The study showed higher PVI in diabetic subjects when compared to control subjects, but no difference between patients with and without manifested coronary artery disease suggesting that various other factors might be associated with the pathogenesis of CAD in patients of DM.

Download Full-text