scholarly journals The Short-Term Kinetics of sICAM-1 after Induction of Acute Experimental Pain in Healthy Volunteers

2021 ◽  
Vol 10 (9) ◽  
pp. 2021
Author(s):  
Philipp Lüke ◽  
Eduard Kraft ◽  
Shahnaz Christina Azad
Keyword(s):  
Chronic Pain ◽  
Pain Intensity ◽  
Experimental Pain ◽  
Heat Pain ◽  
Short Term ◽  
Initial Values ◽  
Chronic Pain Patients ◽  
Pain Patients ◽  
Kinetics Of ◽  
Thermal Stimuli

Intercellular adhesion molecule-1 (ICAM-1) mediates extravasation of leukocytes, releasing proinflammatory cytokines or endogenous opioids in the inflamed tissue. Thus, ICAM-1 is a crucial component of peripheral antinociception. Previously, we demonstrated a significant correlation between the soluble form of ICAM (sICAM-1) in serum and pain intensity reported by chronic pain patients. The present study examines the role and kinetics of sICAM-1 in experimentally induced acute pain. Three groups of 10 subjects were exposed to 10 min of high (capsaicin-enhanced) or low-intensity heat pain or cold pain, respectively. Thermal stimuli were induced using a device for quantitative sensory testing. Topical capsaicin significantly increased heat pain intensity without the risk of thermal tissue damage. Pain intensity was recorded every minute during testing. sICAM-1 concentrations in serum were determined by ELISA before, immediately after, and 60 min after test termination. Among all experimental groups, sICAM-1 significantly decreased immediately after pain induction. After 60 min, sICAM-1 concentrations returned towards initial values. Interestingly, a linear correlation was found between the extent of sICAM-1 changes and the initial concentrations. Whereas high initial values led to a distinct decrease of sICAM-1, low concentrations tended to increase. There was no statistically significant correlation between levels or alterations of serum sICAM-1 and pain intensity reported by the test subjects. In contrast to our previous findings in chronic pain patients, the present results show that sICAM-1 values do not correlate with the intensity of acute experimental pain. However, we were able to detect short-term changes of sICAM-1 after induction of nociceptive thermal stimuli, suggesting that this marker is part of a demand-oriented homeostatically controlled system.

Review of the Performance of Quantitative Sensory Testing Methods to Detect Hyperalgesia in Chronic Pain Patients on Long-term Opioids

2015 ◽  
Vol 122 (3) ◽  
pp. 677-685 ◽  
Author(s):  
Nathaniel P. Katz ◽  
Florence C. Paillard ◽  
Robert R. Edwards
Keyword(s):  
Chronic Pain ◽  
Controlled Trial ◽  
Controlled Study ◽  
Injection Pain ◽  
Heat Pain ◽  
Cold Pain ◽  
Chronic Pain Patients ◽  
Opioid Induced Hyperalgesia ◽  
Pain Patients

Abstract Background: Opioid-induced hyperalgesia is a clinical syndrome whereby patients on long-term opioids become more sensitive to pain while taking opioids. Opioid-induced hyperalgesia is characterized by increased pain intensity over time, spreading of pain to other locations, and increased pain sensation to external stimuli. To characterize opioid-induced hyperalgesia, laboratory methods to measure hyperalgesia have been developed. To determine the performance of these methods, the authors conducted a systematic review of clinical studies that incorporate measures of hyperalgesia in chronic pain patients on long-term opioids. Methods: PubMed and Cochrane databases were searched (terms: opioid induced hyperalgesia, study or trial, and long-term or chronic). Studies published in English were selected if they were conducted in chronic pain patients on long-term opioids and incorporated measures of hyperalgesia; acute/single-dose studies and/or conducted in healthy volunteers were excluded. Results: Fourteen articles made the final selection (11 were selected from the search and 3 others were found from additional sources); there was one randomized controlled trial, one prospective controlled study, three prospective uncontrolled studies, and nine cross-sectional observation studies. Hyperalgesia measurement paradigms used included cold pain, heat pain, pressure pain, electrical pain, ischemic pain, and injection pain. Although none of the stimuli were capable of detecting patients’ hyperalgesia, heat pain sensitivity showed some promising results. Conclusions: None of the measures reviewed herein met the criteria of a definitive standard for the measurement of hyperalgesia. Additional studies that use improved study design should be conducted.

Nitric oxide and pro-inflammatory cytokines correlate with pain intensity in chronic pain patients

2007 ◽  
Vol 56 (1) ◽  
pp. 32-37 ◽  
Author(s):  
A. Koch ◽  
K. Zacharowski ◽  
O. Boehm ◽  
M. Stevens ◽  
P. Lipfert ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Chronic Pain ◽  
Pain Intensity ◽  
Inflammatory Cytokines ◽  
Chronic Pain Patients ◽  
Pain Patients ◽  
Pro Inflammatory Cytokines

The effect of experimentelly induced painful thermal stimuli on chronic pain patients

Pain ◽  
1987 ◽  
Vol 30 ◽  
pp. S312
Author(s):  
C. E. Elger ◽  
H. G. Berwald ◽  
M. Horstmann ◽  
A. C. Ludolph
Keyword(s):  
Chronic Pain ◽  
Chronic Pain Patients ◽  
Pain Patients ◽  
Thermal Stimuli

scholarly journals Startle modulation by heat pain with varying threat levels in chronic pain patients and pain-free controls

2017 ◽  
Vol Volume 10 ◽  
pp. 1787-1800 ◽  
Author(s):  
C Horn-Hofmann ◽  
D Wolf ◽  
S Wolff ◽  
M Heesen ◽  
K Knippenberg-Bigge ◽  
...  
Keyword(s):  
Chronic Pain ◽  
Heat Pain ◽  
Chronic Pain Patients ◽  
Startle Modulation ◽  
Threat Levels ◽  
Pain Patients

scholarly journals Validation and Cross-Cultural Adaptation of the Spanish Version of the Pain Sensitivity Questionnaire (PSQ-S)

2021 ◽  
Vol 11 (1) ◽  
pp. 151
Author(s):  
María del Rocío Ibancos-Losada ◽  
María Catalina Osuna-Pérez ◽  
Irene Cortés-Pérez ◽  
Desirée Montoro-Cárdenas ◽  
Ángeles Díaz-Fernández
Keyword(s):  
Chronic Pain ◽  
Cultural Adaptation ◽  
Pain Sensitivity ◽  
Experimental Pain ◽  
Cross Cultural ◽  
Cross Cultural Adaptation ◽  
Chronic Pain Patients ◽  
Two Factors ◽  
Pain Testing ◽  
Pain Patients

Experimental pain testing requires specific equipment and may be uncomfortable for patients. The Pain Sensitivity Questionnaire (PSQ) was developed to assess pain sensitivity, based on the pain intensity ratings (range: 0–10) of painful situations that occur in daily life. The main objective of this study was to carry out a cross-cultural adaptation and validation of the Spanish version of the PSQ (PSQ-S). A total of 354 subjects (296 healthy and 58 chronic pain patients) filled in the PSQ-S. A subgroup of 116 subjects performed experimental pain testing, including two modalities (cold and pressure), with different measures: pain intensity rating, pressure pain threshold, and tolerance. The validation results showed two factors: PSQ-S-moderate and PSQ-S-minor and, for the total scale and the two factors, an excellent internal consistency (Cronbach’s alpha coefficient > 0.9) and a substantial reliability (Intraclass Correlation Coefficient > 0.8). We obtained strong correlations with all the experimental pain rating parameters, catastrophizing, and depression variables, as well as moderate correlations with anxiety, central sensibilization, and impact on the quality of life. Chronic pain patients received elevated PSQ-S scores compared to healthy controls, and three cut-off values (PSQ-S-total = 7.00, PSQ-S-moderate = 7.57, and PSQ-S-minor = 6.29) based on ROC curve analyses were shown to be able to discriminate between healthy adults and adults with chronic pain. Therefore, PSQ-S may be a simple alternative to experimental pain procedures for clinical and experimental pain research.

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