scholarly journals Pleomorphic Adenoma of the Parotid Gland and the Parapharyngeal Space: Two Diametrically Opposing Surgical Philosophies for the Same Histopathologic Entity? †

2021 ◽  
Vol 11 (1) ◽  
pp. 142
Author(s):  
Benita Hornung ◽  
Jannis Constantinidis ◽  
Vivian Thimsen ◽  
Abbas Agaimy ◽  
Michael Koch ◽  
...  
Keyword(s):  
Retrospective Study ◽  
Parotid Gland ◽  
Incomplete Data ◽  
Parapharyngeal Space ◽  
High Volume ◽  
Study Groups ◽  
Pleomorphic Adenomas ◽  
Medical Referral ◽  
Histopathologic Findings

Background: The aim of this study was to investigate the histopathologic findings in parotid and parapharyngeal pleomorphic adenomas and draw conclusions concerning the surgical strategy. Methods: Retrospective study of medical charts of patients with resected pleomorphic adenomas (PA) between 2005 and 2020 at two tertiary medical referral centers. Histologic specimens were reexamined by an experienced head and neck pathologist. Patients with insufficient/incomplete data were excluded from our study sample. Results: A total of 844 patients formed our study sample (291 men, 553 women, average age 48.9 years); 786 cases had a PA in the parotid gland (PG) (93.1%), and the remaining 58 cases had a PA in the parapharyngeal space (PS) (6.9%). Recurrences were detected in 8/844 cases (7/786 in the PG, 1/58 in the PS, 0.94% in total) with a mean follow-up time of 86.7 months (10–189 months) with no statistically significant differences between the study groups (p = 0.527). Our analysis showed that parapharyngeal pleomorphic adenomas are characterized by a lower incidence of an intact anatomical capsule (71.4% vs. 82.6%, p = 0.035) and a remarkably more frequent occurrence of satellite nodules (20.7% vs. 7.5%, p < 0.001). Conclusions: The more challenging histopathologic profile of parapharyngeal pleomorphic adenomas points towards the fact that parapharyngeal surgery should remain in the hands of experienced surgeons at high-volume centers.

Pleomorphic adenomas of the parotid gland: superficial parotidectomy or limited excision?

1988 ◽  
Vol 102 (7) ◽  
pp. 603-605 ◽  
Author(s):  
C. Wennmo ◽  
O. Spandow ◽  
P. Emgård ◽  
B. Krouthén
Keyword(s):  
Retrospective Study ◽  
Side Effects ◽  
Parotid Gland ◽  
Facial Nerve ◽  
Superficial Parotidectomy ◽  
Operative Results ◽  
Gustatory Sweating ◽  
Pleomorphic Adenomas ◽  
Parotid Tumours

AbstractIn this retrospective study of parotid tumours. 57 patients with pleomorphic adenomas were treated with superficial parotidectomy and 33 patients with limited excision. The follow-up period has been 4–14 years. When the operation was superficial parotidectomy, recurrences occurred in 8.7 per cent compared to 6 per cent in cases of limited excision. Side-effects such as permanent weakness of the facial nerve or postoperative gustatory sweating were also more common when superficial parotidectomy was performed. The post-operative results observed suggest that limited excision under magnification is more favourable than superficial parotidectomy in the treatment of pleomorphic adenomas.

scholarly journals Extracapsular Dissection in Pleomorphic Adenomas of the Parotid Gland: Results After 13 Years of Follow‐up

2020 ◽  
Author(s):  
Mirco Schapher ◽  
Michael Koch ◽  
Miguel Goncalves ◽  
Konstantinos Mantsopoulos ◽  
Heinrich Iro
Keyword(s):  
Parotid Gland ◽  
Extracapsular Dissection ◽  
Pleomorphic Adenomas

scholarly journals Mcl-1 Expression Is Up-Regulated in Malignancies of the Parotid Gland

2011 ◽  
Vol 30 (5) ◽  
pp. 229-233 ◽  
Author(s):  
Gregor Heiduschka ◽  
Boban M. Erovic ◽  
Johannes Pammer ◽  
Ulana Kotowski ◽  
Alexandra Kaider ◽  
...  
Keyword(s):  
Overall Survival ◽  
Retrospective Study ◽  
Statistical Analysis ◽  
Parotid Gland ◽  
Poor Prognosis ◽  
Malignant Tumors ◽  
Gland Tumor ◽  
Parotid Gland Tumor ◽  
Apoptotic Protein ◽  
Pleomorphic Adenomas

The anti-apoptotic protein Mcl-1 is highly expressed in various types of malignant tumors. Overexpression is reported to correlate with poor prognosis and disease progression. We report the expression levels of Mcl-1 in tumor samples of the parotid gland. A retrospective study containing 108 patients was performed. A tissue microarray of six malignancies of the parotid gland and pleomorphic adenoma as control was constructed. Parotid gland tumor samples were immunohistochemically stained for Mcl-1 and expression intensities were assessed. Statistical analysis included correlation to patients' clinical data and comparison of malignancies to the adenoma.All malignancies had significantly higher expression of Mcl-1 than the pleomorphic adenomas. The intensity, however, had no significant correlation to overall survival.Our immunohistochemical findings indicate that parotid gland malignancies produce high levels of Mcl-1 protein. Therefore, Mcl-1 might serve as a predictive co-marker in tumors of the parotid gland.

scholarly journals Excision of tumors in the parapharyngeal space using an endoscopically assisted transoral approach: a case series and literature review

2018 ◽  
Vol 47 (3) ◽  
pp. 1103-1113 ◽  
Author(s):  
Zhe Chen ◽  
Ya-Lian Chen ◽  
Qi Yu ◽  
Shui-Hong Zhou ◽  
Yang-Yang Bao ◽  
...  
Keyword(s):  
Carotid Artery ◽  
Internal Carotid Artery ◽  
Parotid Gland ◽  
Internal Carotid ◽  
Parapharyngeal Space ◽  
Jugular Vein ◽  
Minor Salivary Gland ◽  
Transoral Approach ◽  
Pathological Examination ◽  
Pleomorphic Adenomas

Objective Magnetic resonance imaging (MRI) provides important information regarding tumors in the parapharyngeal space (PPS), revealing their origin, whether they are benign or malignant, and their relationships with surrounding structures. Methods Twelve tumors in the PPS were completely excised using an endoscopically assisted transoral approach (EATA). The MRI features were analyzed. Results Ten pleomorphic adenomas confirmed on postoperative pathological examination had the parotid pedicle sign. A fat space between the tumor and parotid gland may distinguish such a tumor from a tumor arising from a minor salivary gland in the prestyloid space and a tumor arising from the deep lobe of the parotid gland. Both the jugular vein and carotid artery were displaced posteriorly in all 10 cases of pleomorphic adenomas. The principal features of the two schwannomas confirmed on postoperative pathological examination were separation of the internal carotid artery and internal jugular vein and anteromedial displacement of the internal carotid artery, suggesting that the tumors originated in the poststyloid space. In this review, 95 tumors were excised by the EATA in the English-language literature. Conclusions MRI renders differential diagnosis possible. PPS tumors may be completely excised via an EATA guided by tumor features evident on preoperative MRI.

scholarly journals Removal of a Giant Parapharyngeal Space Oncocytoma Without Osteotomy

2021 ◽  
pp. 014556132110489
Author(s):  
Takashi Matsuki ◽  
Shohei Tsutsumi ◽  
Shunsuke Miyamoto ◽  
Koichi Kano ◽  
Kaho Momiyama ◽  
...  
Keyword(s):  
Parotid Gland ◽  
Facial Nerve ◽  
Core Needle Biopsy ◽  
Needle Biopsy ◽  
Parapharyngeal Space ◽  
Core Needle ◽  
Large Size ◽  
Resected Tumor ◽  
Growing Mass

Oncocytoma arising from the parotid gland and extending into the parapharyngeal space (PPS) has not been previously reported. A 64-year-old woman presented with a large slowly growing mass extending from the parotid to the submandibular area, expanding medially to displace the pharynx across the midline. Core-needle biopsy revealed an oncocytoma in the PPS measuring 120 × 88 × 60 mm in size. Although the tumor was of an unprecedentedly large size and extended into multiple spaces, it could be removed via a cervical–parotid approach without osteotomy. The resected tumor was again diagnosed as oncocytoma. A postoperative complication was weakness of the ipsilateral facial nerve, which almost completely resolved in 6 months. No recurrence has been noted on 1 y follow-up. We were able to resect an extremely large oncocytoma arising from the parotid gland without osteotomy.

Sign in / Sign up

Export Citation Format

Share Document