scholarly journals Impact of Smoking Status on Lung Cancer Characteristics and Mortality Rates between Screened and Non-Screened Lung Cancer Cohorts: Real-World Knowledge Translation and Education

2022 ◽  
Vol 12 (1) ◽  
pp. 26
Author(s):  
Fu-Zong Wu ◽  
Yun-Ju Wu ◽  
Chi-Shen Chen ◽  
Shu-Ching Yang

This was a retrospective hospital-based cohort study of participants diagnosed with lung cancer in the lung cancer register database, and our goal was to evaluate the impact of smoking and screening status on lung cancer characteristics and clinical outcomes. According to the hospital-based lung cancer register database, a total of 2883 lung cancers were diagnosed in 2883 patients between January 2007 and September 2017, which were divided into four groups according to smoking and screening status. A comparison was performed in terms of clinical characteristics and outcomes of lung cancer between the four groups. For non-smokers, age, gender, screened status, tumor size, targeted therapy, and curative surgery were independent prognostic factors of overall survival for lung cancer subjects. However, screened status and gender were not significant prognostic factors for lung cancer survival in smokers with lung cancer. For the non-smoker group, about 4.9% of lung cancer subjects (N = 81) were detected by screening. However, only 0.97% of lung cancer subjects (N = 12) were detected by screening in smokers. This could be attributed to smokers’ negative attitudes and low socioeconomic status preventing LDCT lung cancer screening. In summary, our real-world data suggest that effectively encouraging smokers to be more willing to participate in lung cancer screening programs with screening allowance and educational training in the future is an important issue.

Author(s):  
Christopher J Cadham ◽  
Pianpian Cao ◽  
Jinani Jayasekera ◽  
Kathryn L Taylor ◽  
David T Levy ◽  
...  

Abstract Background Guidelines recommend offering cessation interventions to smokers eligible for lung cancer screening, but there is little data comparing specific cessation approaches in this setting. We compared the benefits and costs of different smoking cessation interventions to help screening programs select specific cessation approaches. Methods We conducted a societal-perspective cost-effectiveness analysis using a Cancer Intervention and Surveillance Modeling Network model simulating individuals born in 1960 over their lifetimes. Model inputs were derived from Medicare, national cancer registries, published studies, and micro-costing of cessation interventions. We modeled annual lung cancer screening following 2014 US Preventive Services Task Force guidelines plus cessation interventions offered to current smokers at first screen, including pharmacotherapy only or pharmacotherapy with electronic and/or web-based, telephone, individual, or group counseling. Outcomes included lung cancer cases and deaths, life-years saved, quality-adjusted life-years (QALYs) saved, costs, and incremental cost-effectiveness ratios. Results Compared with screening alone, all cessation interventions decreased cases of and deaths from lung cancer. Compared incrementally, efficient cessation strategies included pharmacotherapy with either web-based cessation ($555 per QALY), telephone counseling ($7562 per QALY), or individual counseling ($35 531 per QALY). Cessation interventions continued to have costs per QALY well below accepted willingness to pay thresholds even with the lowest intervention effects and was more cost-effective in cohorts with higher smoking prevalence. Conclusion All smoking cessation interventions delivered with lung cancer screening are likely to provide benefits at reasonable costs. Because the differences between approaches were small, the choice of intervention should be guided by practical concerns such as staff training and availability.


2018 ◽  
Vol 13 (10) ◽  
pp. S786-S787
Author(s):  
K. Spiegel ◽  
J. Rayburn ◽  
C. Wilshire ◽  
E. Rauch ◽  
J. Handy ◽  
...  

2018 ◽  
Vol 21 (11) ◽  
pp. 1269-1277 ◽  
Author(s):  
Henk Broekhuizen ◽  
Catharina G.M. Groothuis-Oudshoorn ◽  
Rozemarijn Vliegenthart ◽  
Harry J.M. Groen ◽  
Maarten J. IJzerman

2019 ◽  
pp. 225-242
Author(s):  
Meghan Cahill ◽  
Brooke Crawford O'Neill ◽  
Kimberly Del Mauro ◽  
Courtney Yeager ◽  
Bradley B. Pua

2014 ◽  
Vol 14 (S1) ◽  
Author(s):  
MA Heuvelmans ◽  
M Oudkerk ◽  
PA de Jong ◽  
WPTM Mali ◽  
HJM Groen ◽  
...  

CHEST Journal ◽  
2020 ◽  
Vol 157 (2) ◽  
pp. 247-248
Author(s):  
Jonathan M. Iaccarino ◽  
Renda Soylemez Wiener

Lung Cancer ◽  
2019 ◽  
Vol 133 ◽  
pp. 32-37 ◽  
Author(s):  
Margaret Lowenstein ◽  
Maya Vijayaraghavan ◽  
Nancy J. Burke ◽  
Leah Karliner ◽  
Sunny Wang ◽  
...  

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