scholarly journals Circumpapillary Retinal Nerve Fiber Layer OCT Imaging in a Parkinson’s Disease Cohort—A Multidisciplinary Approach in a Clinical Research Hospital

2022 ◽  
Vol 12 (1) ◽  
pp. 80
Author(s):  
Vlad-Ioan Suciu ◽  
Corina-Iuliana Suciu ◽  
Simona-Delia Nicoară ◽  
Lăcrămioara Perju-Dumbravă
Keyword(s):  
Clinical Research ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Multidisciplinary Approach ◽  
Healthy Controls ◽  
Fiber Layer ◽  
Research Hospital ◽  
Nerve Fiber Layer ◽  
Visual Symptoms ◽  
Sd Oct

(1) Background: The purpose of this paper is to report the data of the first study in a Clinical Research Hospital, in the Transylvania region, focusing on the Spectral Domain Optical Coherence Tomography (SD-OCT) measurements in the early stages of Parkinson’s disease (PD), and to compare the results with age-matched healthy controls. (2) Methods: This study assessed the circumpapillary retinal nerve fiber layer (cpRNFL) SD-OCT measurements (Heidelberg Spectralis, Heidelberg Engineering, Germany) of two study groups: patients suffering from PD (Hoehn−Yahr stages 1–3) and healthy controls. Secondary objectives were to investigate the reported visual symptoms by evaluating the color vision, contrast sensitivity, and the central visual defects for macular disease using standardized charts. Subjects with prior history of ophthalmologic diseases, advanced stages of PD (Hoehn−Yahr stages 4–5), or with psychiatric conditions were not included in this study. The same team of neurologists and ophthalmologists evaluated all individuals in order to have comparable data and to eliminate inter-examiner differences. All subjects were recruited from the same Clinical Research Hospital in the Transylvania region, Romania. (3) Results: 72% of the PD patients (n = 17) in this study reported visual symptoms. In respect to the ophthalmologic chart evaluation for PD patients, the most frequent disturbances were identified in the Ishihara color perception testing (33%). The regression analysis showed significant results for the Ishihara testing in relation to the cpRNFL thinning in the temporal retinal sectors for both eyes. cpRNFL thinning was predominantly contralateral to the parkinsonism (p = 0.001). The temporal and global values of the cpRNFL were significantly lower in all PD patients < 70 years old, compared to the age-matched healthy controls. (4) Conclusions: Specific patterns of cpRNFL thinning were found in the PD subjects younger than 70 years. A multidisciplinary approach is essential for a complete evaluation of PD patients.

scholarly journals Detection of Retinal Nerve Fiber Layer Defects in Alzheimer’s Disease Using SD-OCT

2014 ◽  
Vol 5 ◽  
Author(s):  
Robert Kromer ◽  
Nermin Serbecic ◽  
Lucrezia Hausner ◽  
Lutz Froelich ◽  
Fahmy Aboul-Enein ◽  
...  
Keyword(s):  
Alzheimer’S Disease ◽  
Alzheimer's Disease ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Sd Oct ◽  
Retinal Nerve Fiber

scholarly journals Age-Related Physiologic Thinning Rate of the Retinal Nerve Fiber Layer in Different Levels of Myopia

2020 ◽  
Vol 2020 ◽  
pp. 1-6
Author(s):  
Daun Jeong ◽  
Kyung Rim Sung ◽  
Youn Hye Jo ◽  
Sung-cheol Yun
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Refractive Error ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Rnfl Thickness ◽  
Significant Difference ◽  
Thinning Rate ◽  
Sd Oct ◽  
Retinal Nerve Fiber

Purpose. To investigate the effect of refractive error on the physiologic thinning rate of the retinal nerve fiber layer (RNFL) in healthy eyes. Materials and Methods. This study analyzed 223 eyes of 141 healthy subjects followed for more than 5 years and underwent at least five serial spectral domain optical coherence tomography (SD-OCT) examinations. Longitudinal RNFL measurements were analyzed by linear mixed models incorporating follow-up duration, baseline RNFL thickness, spherical equivalent (SE), age, intraocular pressure, and visual field mean deviation. Thinning rates were classified according to SE into three groups: nonmyopic (NM; >0 D), mild-to-moderately myopic (MM; >–6 D and ≤0 D), and highly myopic (HM; ≤–6 D). Results. The overall slopes of change in RNFL thickness over time in the NM, MM, and HM groups were −0.305 ± 0.128, −0.294 ± 0.068, and −0.208 ± 0.097 μm/yr, respectively. Slopes of RNFL thickness changes in these groups were −0.514 ± 0.248, −0.520 ± 0.133, and −0.528 ± 0.188 μm/yr, in the superior quadrant; −0.084 ± 0.145, 0.107 ± 0.082, and −0.161 ± 0.112 μm/yr, in the temporal quadrant; −0.807 ± 0.242, −0.794 ± 0.130, and −0.727 ± 0.183 μm/yr, in the inferior quadrant; and 0.160 ± 0.157, 0.118 ± 0.084, and 0.429 ± 0.119 μm/yr, in the nasal quadrant. Overall and in all four quadrants, there was no significant difference in the rate of RNFL thickness change among the three groups. Conclusions. Refractive error did not affect the physiologic thinning rate of RNFL when assessed by SD OCT.

The Ability of Macular Parameters and Circumpapillary Retinal Nerve Fiber Layer by Three SD-OCT Instruments to Diagnose Highly Myopic Glaucoma

2013 ◽  
Vol 54 (9) ◽  
pp. 6025 ◽  
Author(s):  
Azusa Akashi ◽  
Akiyasu Kanamori ◽  
Makoto Nakamura ◽  
Masashi Fujihara ◽  
Yuko Yamada ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Sd Oct ◽  
Retinal Nerve Fiber

scholarly journals Time-Domain and Spectral-Domain Optical Coherence Tomography of Retinal Nerve Fiber Layer in MS Patients and Healthy Controls

2012 ◽  
Vol 2012 ◽  
pp. 1-7 ◽  
Author(s):  
Alex P. Lange ◽  
Reza Sadjadi ◽  
Jameelah Saeedi ◽  
Janette Lindley ◽  
Fiona Costello ◽  
...  
Keyword(s):  
Optical Coherence Tomography ◽  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Time Domain ◽  
Disease Duration ◽  
Healthy Controls ◽  
Optical Coherence ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
History Of

Objective. The aim of this study was to compare retinal nerve fiber layer thickness (RNFLT) between spectral-domain (SD-) and time-domain optical coherence tomography (TD-OCT) in MS patients and healthy controls (HC). Furthermore, RNFLT between MS eyes with and without optic neuritis (ON) and HC should be explored. Finally, the relationship between RNFLT, disease duration, EDSS, and disease modifying therapy (DMT) should be established.Design. Prospective, cross-sectional study.Participants. 28 MS patients and 35 HC.Methods. Both groups underwent TD- and SD-OCT measurements. RFNLT was correlated between the two machines and between MS eyes with and without ON and HC. Furthermore, RNFLT was correlated to disease duration, EDSS and DMT.Results. A strong correlation (Pearson’sr=0.921,P<0.001), but a statistically significant difference of 2 μm (P<0.001), was found between the two devices. RNFLT was significantly different between MS eyes with history of ON (mean RFNLT (SD) 72.21 μm (15.83 μm)), MS eyes without history of ON 93.03 μm (14.25 μm), and HC 99.07 μm (7.23 μm) (P<0.001).Conclusions. The measurements between different generation of OCT machines are not interchangeable, which should be taken into account if comparing results between different machines and switching OCT machine in longitudinal studies.

Comparative data on SD-OCT for the retinal nerve fiber layer and retinal macular thickness in a large cohort with Marfan syndrome

2017 ◽  
Vol 38 (1) ◽  
pp. 34-38 ◽  
Author(s):  
WanWan Xu ◽  
Sudhi P. Kurup ◽  
Amani A. Fawzi ◽  
Mary K. Durbin ◽  
Irene H. Maumenee ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Marfan Syndrome ◽  
Retinal Nerve Fiber Layer ◽  
Large Cohort ◽  
Macular Thickness ◽  
Comparative Data ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Sd Oct ◽  
Retinal Nerve Fiber

Effects of Axial Length and Age on Circumpapillary Retinal Nerve Fiber Layer and Inner Macular Parameters Measured by 3 Types of SD-OCT Instruments

2016 ◽  
Vol 25 (4) ◽  
pp. 383-389 ◽  
Author(s):  
Kaori Ueda ◽  
Akiyasu Kanamori ◽  
Azusa Akashi ◽  
Mari Tomioka ◽  
Yuki Kawaka ◽  
...  
Keyword(s):  
Nerve Fiber ◽  
Retinal Nerve Fiber Layer ◽  
Axial Length ◽  
Fiber Layer ◽  
Nerve Fiber Layer ◽  
Sd Oct ◽  
Retinal Nerve Fiber
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