scholarly journals Endothelial Dysfunction in Childhood Cancer Survivors: A Narrative Review

Life ◽  
2021 ◽  
Vol 12 (1) ◽  
pp. 45
Author(s):  
Marco Crocco ◽  
Giuseppe d’Annunzio ◽  
Alberto La Valle ◽  
Gianluca Piccolo ◽  
Decimo Silvio Chiarenza ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Endothelial Function ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Narrative Review ◽  
Cancer Therapies ◽  
Pharmacological Interventions ◽  
Treatment Protocols ◽  
Non Invasive

Assessment of endothelial dysfunction in cancer survivors may have a role in the early identification of non-communicable diseases and cardiovascular late effects. Oncological therapies may impair endothelial function. Therefore, in patients such as childhood cancer survivors who could benefit from early cardioprotective pharmacological interventions, it is essential to monitor endothelial function, even if the optimal methodology for investigating the multifaceted aspects of endothelial dysfunction is still under debate. Biochemical markers, as well as invasive and non-invasive tools with and without pharmacological stimuli have been studied. Human clinical studies that have examined lifestyle or cancer treatment protocols have yielded evidence showing the involvement of lipid and lipoprotein levels, glycemic control, blood pressure, adiposity, inflammation, and oxidative stress markers on the state of endothelial health and its role as an early indicator of cardiometabolic risk. However, with regards to pharmacological interventions, cautious interpretation of the result attained whilst monitoring the endothelial function is warranted due to methodological limitations and substantial heterogeneity of the results reported in the published studies. In this narrative review, an overview of evidence from human clinical trials examining the effects of cancer therapies on endothelial disease is provided together with a discussion of endothelial function assessment using the different non-invasive techniques available for researchers and clinicians, in recent years.

Non-invasive evaluation of late cardiac toxicity in childhood cancer survivors

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 6047-6047
Author(s):  
M. M. Hudson ◽  
S. N. Rai ◽  
X. Deng ◽  
T. Merchant ◽  
N. Marina ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cardiac Toxicity ◽  
Childhood Cancer Survivors ◽  
Non Invasive ◽  
Invasive Evaluation

Endothelial dysfunction in adult survivors of childhood cancer: A report from the St. Jude Lifetime Cohort study.

2017 ◽  
Vol 35 (15_suppl) ◽  
pp. 10564-10564
Author(s):  
Daniel A. Mulrooney ◽  
Kirsten K. Ness ◽  
Sujuan Huang ◽  
Aimee Santucci ◽  
Robert P. Hebbel ◽  
...  
Keyword(s):  
Endothelial Dysfunction ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Vascular Inflammation ◽  
High Sensitivity ◽  
Adult Survivors ◽  
Childhood Cancer Survivors ◽  
Reactive Protein ◽  
Inflammatory Processes ◽  
Cardiovascular Medications

10564 Background: Endothelial dysfunction, as an indicator of vascular disease in childhood cancer survivors (CCS) has not been widely studied. Methods: Markers of vascular inflammation (high sensitivity C-reactive protein [hsCRP]), hemostasis (fibrinogen), activation (endothelial cell expression of vascular cell adhesion molecule [VCAM-1]) and functional testing (large/small artery elasticity [L/SAE], pulse wave velocity [PWV]) were assessed in 200 CCS, ≥10 years from diagnosis, and 192 age/gender matched healthy controls. Exclusion criteria included: inflammatory processes, use of anti-inflammatory or cardiovascular medications, or pregnancy. Differences were assessed by adjusted multivariable linear regression. Results: CCS (53% male) of leukemia/lymphoma (59%), central nervous system tumors (6%), sarcomas (11.5%), embryonal tumors (22.5%), and other (1%) had a mean age at diagnosis 7.3 years (SD ±5.7). CCS and controls did not differ in current age (mean 34.1 ±9.2 vs. 33.5 years ±9.8), body mass index, smoking, mean systolic (124 mm Hg ±11.7 vs. 123 ±11.9) or diastolic blood pressure (73 ±9.5 vs. 71 ±9.5). Fasting low- (110 mg/dl ±31 vs. 102 ±30) and high-density (52 ±16 vs. 56 ±18) cholesterol levels differed between survivors and controls (p<0.01). Endothelial expression of VCAM-1 and PWV were statistically significantly increased in CCS; arterial elasticity was significantly reduced (table). Therapeutic exposures (anthracyclines and radiation) were not significantly associated with endothelial dysfunction. Conclusions: Childhood cancer survivors have greater endothelial dysfunction, a sign of atherosclerosis, and preventive measures should be investigated. [Table: see text]

scholarly journals Exploring contributors to cancer-related fatigue in childhood cancer survivors and the use of non-pharmacological interventions

2021 ◽  
Vol Publish Ahead of Print ◽  
Author(s):  
Ariane Levesque ◽  
Maxime Caru ◽  
Michel Duval ◽  
Caroline Laverdière ◽  
Serge Sultan
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Pharmacological Interventions ◽  
Cancer Related Fatigue

Non-invasive evaluation of late cardiac toxicity in childhood cancer survivors

2004 ◽  
Vol 22 (14_suppl) ◽  
pp. 6047-6047
Author(s):  
M. M. Hudson ◽  
S. N. Rai ◽  
X. Deng ◽  
T. Merchant ◽  
N. Marina ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Cardiac Toxicity ◽  
Childhood Cancer Survivors ◽  
Non Invasive ◽  
Invasive Evaluation

scholarly journals Heart failure in childhood cancer survivors – A systematic review protocol

2021 ◽  
Author(s):  
Tove Berg ◽  
Jens Böhmer ◽  
Bright Nwaru ◽  
Kristjan Karason ◽  
Marianne Jarfelt
Keyword(s):  
Heart Failure ◽  
Systematic Review ◽  
Cancer Survivors ◽  
Childhood Cancer ◽  
Meta Analysis ◽  
Public Health Practice ◽  
Childhood Cancer Survivors ◽  
Population Based ◽  
Cardiac Complications ◽  
Treatment Protocols

Abstract BackgroundOver the past decades, survival rate for childhood cancer has greatly improved. However, the risk of late cardiac complications after such treatment remains high. Previous studies have shown that the risk for heart failure among childhood cancer survivors is significantly higher than that observed in the general population. The aim of this systematic review is to identify, critically appraise and synthesize existing population-based studies reporting on the frequency of heart failure, both incidence or prevalence, that may develop after treatment of childhood cancer.Method:The following databases will be searched from their inception date until May 17th 2021: Medline, Embase, Scopus, CINAHL, CAB International, AMED, Global Health, Psycinfo, Web of science and Google Scholar. Population-based studies reporting on the incidence and/or prevalence of heart failure after treatment of any type of childhood cancer will be included. Screening of articles, data extraction and quality assessment will be performed independently by two reviewers. The quality and risk of bias in the studies included will be assessed by using the Effective Public Health Practice Project tool. A narrative synthesis of the extracted data will be undertaken and, for studies that are sufficiently homogenous, a meta-analysis using random-effects models performed.DiscussionThis systematic review will provide a clearer picture of the epidemiology of heart failure after treatment of childhood cancer. Collected data will be of value for future childhood cancer treatment protocols and also offer guidance for post-treatment cardiac surveillance among survivors.Systematic review registrationThis protocol follows the structure of the recommendation of the preferred reporting items for systematic review and meta-analysis protocols (PRISMA-P) and has been submitted in PROSPERO on April 28th 2021, awaiting assignment of registration number.

Examining neurodevelopmental outcomes among bilingual childhood cancer survivors

2008 ◽  
Author(s):  
Lauren A. Mikula ◽  
Julie Snyder ◽  
Anai M. Cuadra ◽  
Maria L. Goldman ◽  
Wendy E. Sulc ◽  
...  
Keyword(s):  
Cancer Survivors ◽  
Childhood Cancer ◽  
Childhood Cancer Survivors ◽  
Neurodevelopmental Outcomes
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