scholarly journals Four New Isocoumarins and a New Natural Tryptamine with Antifungal Activities from a Mangrove Endophytic Fungus Botryosphaeria ramosa L29

Marine Drugs ◽  
2019 ◽  
Vol 17 (2) ◽  
pp. 88 ◽  
Author(s):  
Zhihui Wu ◽  
Jiaqing Chen ◽  
Xiaolin Zhang ◽  
Zelin Chen ◽  
Tong Li ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Culture Medium ◽  
Spectroscopic Analysis ◽  
Calculated Data ◽  
Cd Spectra ◽  
Mangrove Endophytic Fungus ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Weak Growth ◽  
Inhibitory Activities

Four new isocoumarin derivatives, botryospyrones A (1), B (2), C (3), and D (4), and a new natural tryptamine, (3aS, 8aS)-1-acetyl-1, 2, 3, 3a, 8, 8a-hexahydropyrrolo [2,3b] indol-3a-ol (5), were isolated from a marine mangrove endophytic fungus Botryosphaeria ramosa L29, obtained from the leaf of Myoporum bontioides. Their structures were elucidated using spectroscopic analysis. The absolute configurations of compounds 3, 4, and 5 were determined by comparison of their circular dichroism (CD) spectra with the calculated data. The inhibitory activities of compound 1 on Fusarium oxysporum, of compounds 2 and 3 on F. oxysporum and Fusarium graminearum, and of compound 5 on F. oxysporum, Penicillium italicum, and F. graminearum were higher than those of triadimefon, widely used as an agricultural fungicide. Compound 5 was produced after using the strategy we called “using inhibitory stress from components of the host” (UISCH), wherein (2R, 3R)-3, 5, 7-trihydroxyflavanone 3-acetate, a component of M. bontioides with weak growth inhibitory activity towards B. ramosa L29, was introduced into the culture medium.

(+)- and (−)-Ascomlactone A: a pair of novel dimeric polyketides from a mangrove endophytic fungus Ascomycota sp. SK2YWS-L

2017 ◽  
Vol 15 (48) ◽  
pp. 10276-10280 ◽  
Author(s):  
Zhaoming Liu ◽  
Senhua Chen ◽  
Pei Qiu ◽  
Chunbing Tan ◽  
Yuhua Long ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Mangrove Endophytic Fungus ◽  
Inhibitory Activities

Two novel enantiomeric polyketide dimers were obtained from a mangrove endophytic fungus Ascomycota sp. with potential α-glucosidase inhibitory activities.

scholarly journals Two New Aromadendrane Sesquiterpenes from the Stem Bark of Alafia multiflora

2014 ◽  
Vol 9 (12) ◽  
pp. 1934578X1400901
Author(s):  
Alembert T. Tchinda ◽  
David E. Tsala ◽  
Nnanga Nga ◽  
Ewa Cieckiewicz ◽  
Robert Kiss ◽  
...  
Keyword(s):  
Inhibitory Activity ◽  
2D Nmr ◽  
Stem Bark ◽  
Dioic Acid ◽  
Murine Melanoma ◽  
Spectroscopic Analyses ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Weak Growth

Two new aromadendrane sesquiterpenoids (1β,4β,5β,6α,7α,11 S)-aromadendr-9-en-13,14-dioic acid (1) and (1β,4β,5β,6α,7α,11 S)-13-oxoaromadendr-9-en-14-oic acid (2) have been isolated from the stem bark of Alafia multiflora along with β-sitosterol and β-sitosterol glucoside. Their structures were established on the basis of spectroscopic analyses, including 1D and 2D NMR experiments (1H-1H COSY, NOESY, HSQC, HMBC). Compound 1 showed a weak growth inhibitory activity against the murine melanoma line B16F10 MTT.

scholarly journals Terpenoids from the Fermented Broths of Coprinellus radians

2016 ◽  
Vol 11 (9) ◽  
pp. 1934578X1601100
Author(s):  
Ming-Shian Lee ◽  
Che-Jen Hsiao ◽  
Yu-Ming Ju ◽  
Yueh-Hsiung Kuo ◽  
Ruo-Kai Lin ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
Antifungal Activity ◽  
Spectroscopic Data ◽  
Fungal Strain ◽  
Moderate Growth ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Inhibitory Activities ◽  
Ethyl Acetate Extracts

One new sesquiterpenoid, namely coprinol (1), along with guanacastanes J (2), E (3) and N (4), were isolated from the ethyl acetate extracts of the fermented broths of the fungal strain Coprinellus radians#1168. Their structures were elucidated on the basis of spectroscopic data analysis. The growth inhibitory activities against A549 of 1-4 were evaluated, and only 4 exhibited moderate growth inhibitory activity with a GI50 value of 18.2 μM compared with fluorouracil (GI50 = 3.6 μM). All the compounds were also subjected to antifungal assay against Candida albicans ATCC 18804, C. albicans SC-5314, Cryptococcus neoformans ATCC 13690 and Saccharomyces cerevisiae ATCC 2345; all showed mild antifungal activity with MIC values of 128.0 μg/mL for 1-3 and 64.0 μg/mL for 4 in comparison with amphotericin B (MIC = 0.25 μg/mL) and ketoconazole (MIC = 1.0 μg/mL).

scholarly journals Two New 11(15→1)Abeotaxanes with a 2,20-Epoxy Ring from the Needles of Taxus canadensis

2009 ◽  
Vol 64 (1-2) ◽  
pp. 43-48 ◽  
Author(s):  
Man-Li Zhang ◽  
Jing Zhang ◽  
Mei Dong ◽  
Shu-Hua Feng ◽  
Chang-Hong Huo ◽  
...  
Keyword(s):  
High Resolution ◽  
2D Nmr ◽  
Epoxy Ring ◽  
Taxus Canadensis ◽  
Growth Inhibitory ◽  
Weak Growth ◽  
Inhibitory Activities ◽  
First Time

1Two 11(15→1)abeotaxanes having a tetrahydrofuran ring along the carbon atoms C-2, C-3, C-4, C-20 were identified for the first time from the needles of the Canadian yew, Taxus canadensis. The compounds could be identified as 4α,10β,13α-triacetoxy-15-benzoyloxy-2α,20β- epoxy-11(15→1)abeotax-11-ene-5α,7β,9α-triol () and 4α,7β,9α,10β,15-pentaacetoxy-2α,20β- epoxy-11(15→1)abeotax-11-ene-5α,13α-diol (2) on the basis of 1D-, 2D-NMR evidence and high-resolution FABMS analysis. Compound 1 showed weak growth inhibitory activities against T-98 and MM1-CB cells in vitro.

Metabolites with phytopathogenic fungi inhibitory activities from the mangrove endophytic fungus Botryosphaeria ramose

2020 ◽  
Vol 104 ◽  
pp. 104300
Author(s):  
Zhibo Hu ◽  
Zhihui Wu ◽  
Qinhua Su ◽  
Mingzhe Li ◽  
Shanshan Wu ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Phytopathogenic Fungi ◽  
Mangrove Endophytic Fungus ◽  
Inhibitory Activities

Metabolites with anti-inflammatory and α-glucosidase inhibitory activities from the mangrove endophytic fungus Phoma sp. SYSU-SK-7

2020 ◽  
Vol 61 (48) ◽  
pp. 152578 ◽  
Author(s):  
Yan Chen ◽  
Wencong Yang ◽  
Ge Zou ◽  
Zhangyuan Yan ◽  
Pei Qiu ◽  
...  
Keyword(s):  
Endophytic Fungus ◽  
Mangrove Endophytic Fungus ◽  
Inhibitory Activities ◽  
Anti Inflammatory

scholarly journals Synthesis and Bioevaluation of Thieno[2,3-d]pyrimidinone Derivatives as Potential Tumor Cell Growth Inhibitors

2013 ◽  
Vol 2013 ◽  
pp. 1-6 ◽  
Author(s):  
Huangyong Li ◽  
Changshui Chen ◽  
Shengzhen Xu ◽  
Xiufang Cao
Keyword(s):  
Cell Growth ◽  
Tumor Cell ◽  
Bioactive Molecules ◽  
Tumor Cell Growth ◽  
Growth Inhibitors ◽  
Growth Inhibitory ◽  
Growth Inhibitory Activity ◽  
Inhibitory Activities ◽  
Alkylation Reactions ◽  
Mcf 7

A series of novel cycloalkylthieno[2,3-d]pyrimidinone derivatives have been conveniently synthesizedviathree steps including G-3CR, heterocyclization, and alkylation reactions as a part of our ongoing search for new bioactive molecules. The newly synthesized compounds were evaluated for their potential tumor cell growth inhibitory activity by standard MTT assay. The preliminary results show that compound6bexhibited better inhibitory activities against HepG2, MCF-7, and BCG-823 cell lines compared to the control.

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