Microalgal Peloids for Cosmetic and Wellness Uses

Peloids have been used for therapeutic purposes since time immemorial, mainly in the treatment of locomotor system pathologies and dermatology. Their effects are attributed to their components, i.e., to the properties and action of mineral waters, clays, and their biological fraction, which may be made up of microalgae, cyanobacteria, and other organisms present in water and clays. There are many studies on the therapeutic use of peloids made with microalgae/cyanobacteria, but very little research has been done on dermocosmetic applications. Such research demonstrates their potential as soothing, regenerating, antioxidant, anti-inflammatory, and antimicrobial agents. In this work, a method for the manufacture of a dermocosmetic peloid is presented based on the experience of the authors and existing publications, with indications for its characterization and study of its efficacy.

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Therapeutic use of lowmolecular weight heparin for capillaritis alba

Phlebologie ◽

10.1055/s-0037-1622240 ◽

2008 ◽

Vol 37 (05) ◽

pp. 259-265 ◽

Cited By ~ 11

Author(s):

H. Kutzner ◽

G. Hesse

Keyword(s):

Case Studies ◽

Randomized Study ◽

Compression Therapy ◽

Venous Hypertension ◽

Therapeutic Use ◽

Prospective Randomized Study ◽

Anti Inflammatory ◽

Positive Effect ◽

Inflammatory Effect

SummaryThe reason of the so called ulcerated capillaritis alba or idiopathic atrophie blanche is vasculopathy caused by severe venous hypertension. Thrombosed and rarificated vessels worsen the oxygenation, increase permanent inflammation and impede the necessary compression therapy. The anti-inflammatory effects of heparin alleviate pain and being independent from the antithrombotic ones it needs much lower doses for treatment. This anti-inflammatory effect is now becoming more important in clinical phlebology. Case studies of more than 50 patients and one prospective randomized study of 87 patients clearly demonstrate the ameliorated healing of ulcerated atrophie blanche. In our office we could document this positive effect with 22 patients. We present the pathophysiology of low molecular heparins for ulcerated capillaritis alba and our own experiences with it.

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Indications and patterns of therapeutic use of antimicrobial agents in the Danish pig production from 2002 to 2008

Journal of Veterinary Pharmacology and Therapeutics ◽

10.1111/j.1365-2885.2011.01291.x ◽

2011 ◽

Vol 35 (1) ◽

pp. 33-46 ◽

Cited By ~ 33

Author(s):

V. F. JENSEN ◽

H.-D. EMBORG ◽

F. M. AARESTRUP

Keyword(s):

Antimicrobial Agents ◽

Therapeutic Use ◽

Pig Production

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Characterization of fluoroquinolone-induced Achilles tendon toxicity in rats: comparison of toxicities of 10 fluoroquinolones and effects of anti-inflammatory compounds.

Antimicrobial Agents and Chemotherapy ◽

10.1128/aac.41.11.2389 ◽

1997 ◽

Vol 41 (11) ◽

pp. 2389-2393 ◽

Cited By ~ 64

Author(s):

Y Kashida ◽

M Kato

Keyword(s):

Nitric Oxide ◽

Body Weight ◽

Methyl Ester ◽

Achilles Tendon ◽

Antibacterial Agents ◽

Antimicrobial Agents ◽

High Dose ◽

Juvenile Rats ◽

Anti Inflammatory

Fluoroquinolone antibacterial agents have been reported to induce tendon lesions in juvenile rats. In the present study, we characterized fluoroquinolone-induced Achilles tendon lesions by comparing the effects of 10 fluoroquinolones and examining the potential of one of these antimicrobial agents, pefloxacin, to induce tendon lesions when coadministered with one of nine anti-inflammatory compounds. Among the 10 fluoroquinolones tested, fleroxacin and pefloxacin were the most toxic, inducing lesions at a dose of 100 mg/kg of body weight or more, while lomefloxacin, levofloxacin, and ofloxacin or sparfloxacin and enoxacin induced lesions at 300 mg/kg or more and 900 mg/kg, respectively. In contrast, norfloxacin, ciprofloxacin, and tosufloxacin had no effect even at the high dose of 900 mg/kg. The severity of the Achilles tendon lesions appeared to correlate with the structure of the substituent at the seventh position. Furthermore, pefloxacin-induced tendon lesions were inhibited by coadministration with dexamethasone and N-nitro-L-arginine methyl ester. Phenidone (1-phenyl-3-pyrazolidinone) and 2-(12-hydroxydodeca-5,10-diynyl)3,5,6-trimethyl-1,4-benzoqui none (AA861) also decreased the incidence of tendon lesions. In contrast, catalase, dimethyl sulfoxide, indomethacin, pyrilamine, and cimetidine did not modify these tendon lesions. These results suggest that nitric oxide and 5-lipoxigenase products partly mediate fluoroquinolone-induced tendon lesions.

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Synthesis, biological evaluation and molecular modeling of novel thienopyrimidinone and triazolothienopyrimidinone derivatives as dual anti-inflammatory antimicrobial agents

Bioorganic Chemistry ◽

10.1016/j.bioorg.2017.12.028 ◽

2018 ◽

Vol 77 ◽

pp. 38-46 ◽

Cited By ~ 8

Author(s):

Adnan A. Bekhit ◽

Ahmed M. Farghaly ◽

Ragab M. Shafik ◽

Mona M.A. Elsemary ◽

Alaa El-Din A. Bekhit ◽

...

Keyword(s):

Molecular Modeling ◽

Antimicrobial Agents ◽

Biological Evaluation ◽

Anti Inflammatory

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Design and synthesis of novel isatin derivatives as potent analgesic, anti-inflammatory and antimicrobial agents

Journal of Chemical Sciences ◽

10.1007/s12039-020-01795-0 ◽

2020 ◽

Vol 132 (1) ◽

Cited By ~ 1

Author(s):

Kosaraju Lahari ◽

Raja Sundararajan

Keyword(s):

Antimicrobial Agents ◽

Design And Synthesis ◽

Anti Inflammatory ◽

Isatin Derivatives

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New triorganotin(IV) derivatives of dipeptides as anti-inflammatory–antimicrobial agents

European Journal of Medicinal Chemistry ◽

10.1016/j.ejmech.2004.11.001 ◽

2005 ◽

Vol 40 (3) ◽

pp. 289-298 ◽

Cited By ~ 38

Author(s):

Mala Nath ◽

Sandeep Pokharia ◽

George Eng ◽

Xueqing Song ◽

Ashok Kumar

Keyword(s):

Antimicrobial Agents ◽

Anti Inflammatory ◽

Derivatives Of

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The impact of non-pharmacological treatments for diseases of the locomotor system on the prescribed drug use and lifestyles of the patients in the sanatoria in Busko-Zdroj

Current Issues in Pharmacy and Medical Sciences ◽

10.1515/cipms-2015-0088 ◽

2015 ◽

Vol 28 (4) ◽

pp. 273-277

Author(s):

Milena Korczak ◽

Jacek Owczarek

Keyword(s):

Quality Of Life ◽

Rheumatoid Arthritis ◽

Drug Use ◽

Pharmacological Treatments ◽

Locomotor System ◽

The Third ◽

Inflammatory Drugs ◽

Anti Inflammatory ◽

The Impact

Abstract The article is the result of research on the impact of non-pharmacological therapies for diseases of the locomotor system on the prescribed drug use and lifestyles of the patients of the sanatoria in Busko-Zdroj. The reported research uses primary and secondary measures. The former includes the assessment of the impact of non-pharmacological sanatorium treatments for locomotor system diseases on the use of prescribed drug regimes, while the latter is aimed at assessing the patients’ quality of life. The research was conducted on adult patients of both genders in the sanatoria in Busko-Zdroj. The subjects were patients suffering from disorders of the musculoskeletal system such as rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, osteoporosis and discopathies. The research included two visits, the first at the start of the research and the second at the end of the research. The patients were examined for a period of three consecutive weeks. The study involved 170 patients, 50% of them were women and 50% men. A decline in the use of painkillers and anti-inflammatory drugs makes a very interesting finding. After the first week, as many as 38% of the examined patients limited the use of painkillers and/or anti-inflammatory drugs. After the second week, 62% of the patients reduced the use of the drugs, and after the third week of treatment, up to 90% of the patients did so. The improvement of patients’ lives is noticeable in the psychological, physical and motor fields.

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