Therapeutic use of lowmolecular weight heparin for capillaritis alba

SummaryThe reason of the so called ulcerated capillaritis alba or idiopathic atrophie blanche is vasculopathy caused by severe venous hypertension. Thrombosed and rarificated vessels worsen the oxygenation, increase permanent inflammation and impede the necessary compression therapy. The anti-inflammatory effects of heparin alleviate pain and being independent from the antithrombotic ones it needs much lower doses for treatment. This anti-inflammatory effect is now becoming more important in clinical phlebology. Case studies of more than 50 patients and one prospective randomized study of 87 patients clearly demonstrate the ameliorated healing of ulcerated atrophie blanche. In our office we could document this positive effect with 22 patients. We present the pathophysiology of low molecular heparins for ulcerated capillaritis alba and our own experiences with it.

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The anti-inflammatory effect of the synthetic antimicrobial peptide 19-2.5 in a murine sepsis model: a prospective randomized study

Critical Care ◽

10.1186/cc11920 ◽

2013 ◽

Vol 17 (1) ◽

pp. R3 ◽

Cited By ~ 32

Author(s):

Tobias Schuerholz ◽

Sabine Doemming ◽

Mathias Hornef ◽

Lukas Martin ◽

Tim-Philipp Simon ◽

...

Keyword(s):

Antimicrobial Peptide ◽

Randomized Study ◽

Prospective Randomized Study ◽

Sepsis Model ◽

Anti Inflammatory ◽

Inflammatory Effect

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Does eradication of Helicobacter pylori impair healing of nonsteroidal anti-inflammatory drug associated bleeding peptic ulcers? A prospective randomized study

Alimentary Pharmacology & Therapeutics ◽

10.1046/j.1365-2036.1998.00434.x ◽

1998 ◽

Vol 12 (12) ◽

pp. 1201-1205 ◽

Cited By ~ 63

Author(s):

Chan ◽

Sung ◽

Suen ◽

Lee ◽

Wu ◽

...

Keyword(s):

Helicobacter Pylori ◽

Randomized Study ◽

Prospective Randomized Study ◽

Peptic Ulcers ◽

Inflammatory Drug ◽

Bleeding Peptic Ulcers ◽

Anti Inflammatory

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STUDY OF ANTI-INFLAMMATORY EFFECT OF CONCENTRATED JUICE AND GRANULES FROM VACCINIUM OXYCOCCOS FRUITS ON THE MODEL OF BACTERIAL CYSTITIS IN RATS

EUREKA Health Sciences ◽

10.21303/2504-5679.2020.001505 ◽

2020 ◽

pp. 88-94

Author(s):

Kateryna Yatsyuk ◽

Mariana Fedorovska ◽

Olga Antymis

Keyword(s):

Blood Vessels ◽

Bladder Wall ◽

Coli Strain ◽

Transitional Epithelium ◽

Reference Drug ◽

E Coli ◽

Histological Picture ◽

Anti Inflammatory ◽

Positive Effect ◽

Inflammatory Effect

The fruits of marsh cranberries due to the content of phenolic compounds, in particular proanthocyanidins, are effective in the prevention and treatment of cystitis [1]. The aim of the research was to study the anti-inflammatory properties of condensed juice of Vaccinium oxycoccos fruits and granules “Cranberry” in a model of acute bacterial cystitis in rats. Materials and methods. The anti-inflammatory properties of condensed juice from Vaccinium oxycoccos fruits and granules “Cranberry” were studied in a model of acute bacterial cystitis in rats, which was caused by three daily transurethral injection into the bladder of 0.3 ml of E. coli strain at a concentration of 106 CFU/ml. “Canefron® H” was used as a reference drug. Tissues were studied histologically by assessing the structure of the bladder wall and the condition of blood vessels. Results. Infection of animals with E. coli resulted in a significant increase in the desquamation of the transitional epithelium, edematous changes and narrowing of blood vessels in the tissues of the bladder wall. During treatment with the drug “Canefron® N” there was a decrease in cell infiltration and desquamation of cells, dilation of blood vessels. When animals used condensed juice from Vaccinium oxycoccos fruits and granules “Cranberry” in the histological picture of the walls of the bladder there was a decrease in desquamation, edema and cellular infiltration, the lumen of blood vessels was approaching normal. Conclusions. The use of condensed juice from Vaccinium oxycoccos fruits and granules “Cranberry” was accompanied by a positive effect on the tissues of the walls and blood vessels of the bladder of rats (there was a decrease in desquamation of the superficial layers of the transitional epithelium and normalization of the histological picture of vascular entanglement, that was not inferior to the comparison drug “Canefron® N”.

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The Anti-inflammatory Effect of Dexmedetomidine Administration on Patients Undergoing Intestinal Surgery: A Randomized Study

Drugs in R&D ◽

10.1007/s40268-021-00368-x ◽

2021 ◽

Author(s):

Rushuang Chen ◽

Zhenming Kang ◽

Yaduan Wang ◽

Jie Zhao ◽

Shunyuan Li

Keyword(s):

Randomized Study ◽

Intestinal Surgery ◽

Anti Inflammatory ◽

Inflammatory Effect

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Właściwości prozdrowotne pochrzynu (słodkie ziemniaki)

Medycyna Rodzinna ◽

10.25121/mr.2018.21.1.53 ◽

2018 ◽

Vol 21 (1) ◽

Author(s):

Elżbieta Kołeczek ◽

Michalina Horochowska ◽

Zygmunt Zdrojewicz ◽

Jacek Jagiełło ◽

Jacek Łazeczko

Keyword(s):

Digestive System ◽

Metabolic Diseases ◽

Bacterial Flora ◽

Antioxidant Properties ◽

Dioscorea Alata ◽

Protein Levels ◽

Natural Medicine ◽

Anti Inflammatory ◽

Positive Effect ◽

Inflammatory Effect

Dioscorea spp., sometimes called yam, is a genus of around 600 species of tuberous climbers. Since ages it has been used as a food source and in the natural medicine. It contains many fitochemical substances: diterpenoids, glycosides, steroids, saponines and sapogenines. Thanks to this it can be used as a medicine in metabolic diseases, such as diabetes, obesity and hypercholesterolemia. Diosgenin present in the plant stimulates differentiation of fatty cells and eliminate ongoing inflammation. Additionaly, it lowers the amount of triglicerydes and LDL, acting positively on the diabetes related dyslipidemia, lowering the glucose level likewise. Antimicrobial action allows yam to be used against infections, with the possibility of it’s being used against HIV infection. Due to anticancer, anti-inflammatory and antioxidant properties of some polysaccharides present in Dioscorea bulbifera it can be helpful in the adjuvant therapy of cervical cancer and in the therapy of either sarcomas or liver cancer. Since years, analgetic and anti-inflammatory effect of Yam has been used in the traditional medicine of Kamerun. Studies performed on mice proved analgetic action of Dioscorea alata against neuropatic pain, as well as pain releated to inflammation, probably by reducing the level of inflammatory mediators. Studies performed on rats revealed positive effect of usage of Dioscorea alata in the condition of low blood estrogen levels, what presented by lowering anxiety levels and action against lowering of the density of bone tissue. It’s administration in postmenopausal women led to increase in blood estron, estradiol and sex hormones binding protein levels. Due to this action it can counteract against adverse changes caused by reduced level of those hormones. Additionaly, surves have shown beneficial influence of yam on the digestive system, by increasing the level of symbiotic bacterial flora and reducing vulnerability to the toxic effect of lipopolysaccharide.

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Strategy for the management of osteoarthritis in multimorbid patients: the balance of effectiveness and safety while choosing drug therapy

Medical Council ◽

10.21518/2079-701x-2020-11-164-176 ◽

2020 ◽

pp. 164-176 ◽

Cited By ~ 1

Author(s):

K. Yu. Belova ◽

A. V. Nazarova

Keyword(s):

Therapeutic Potential ◽

Structural Components ◽

Risk Of Death ◽

Egg Membrane ◽

Anti Inflammatory ◽

Multimorbid Patients ◽

Positive Effect ◽

And Oxidative Stress ◽

Pro Inflammatory Cytokines ◽

Inflammatory Effect

Due to the increase in life expectancy, the number of elderly and senile people with various chronic diseases is growing. One of the most common diseases of the musculoskeletal system is osteoarthritis. According to existing recommendations among all medications the leading place in the treatment of patients with osteoarthritis is given to symptomatic slowacting drugs (SYSADOA). Data from numerous studies show that these patients are often multimorbid, and this fact significantly restricts the appointment of many medications. In such cases, the use of drugs from the SYSADOA group becomes the basis of therapy due to their safety. Medications of this group include chondroitin sulfate and glucosamine sulfate. They are the main structural components of cartilage and synovial fluid and they are used for the synthesis of glycosaminoglycans, they reduce the degradation of cartilage, and also exhibit analgesic and anti-inflammatory effects. In addition, a number of other pleiotropic effects of these drugs have been shown, including a positive effect on muscles in sarcopenia, on reducing the risk of death from several cancers and complications of diabetes mellitus. In recent years, there has also been evidence of the use of the natural egg membrane preparation (NEM), which contains natural glycosaminoglycans and proteins necessary for maintaining the condition of the cartilage and synovial membrane. Studies have shown its anti-inflammatory effect, reducing the intensity of pain and improving functional indicators in patients with osteoarthritis. There was also a decrease in the production of pro-inflammatory cytokines in osteoarthritis for the plant-derived substance harpagophytum, which has therapeutic potential in the treatment of diseases associated with inflammation and oxidative stress.

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A Double-Blinded Randomized Study Investigating a Possible Anti-Inflammatory Effect of Saxagliptin versus Placebo as Add-On Therapy in Patients with Both Type 2 Diabetes And Stable Coronary Artery Disease

Mediators of Inflammation ◽

10.1155/2017/5380638 ◽

2017 ◽

Vol 2017 ◽

pp. 1-9 ◽

Cited By ~ 1

Author(s):

Ida Unhammer Njerve ◽

Sissel Åkra ◽

Thomas W. Weiss ◽

Svein Solheim ◽

Reidun Øvstebø ◽

...

Keyword(s):

Coronary Artery Disease ◽

Coronary Artery ◽

Mononuclear Cells ◽

Ex Vivo ◽

Stable Coronary Artery Disease ◽

Randomized Study ◽

Peripheral Blood Mononuclear ◽

Anti Inflammatory ◽

Artery Disease ◽

Inflammatory Effect

Background. Promising results regarding potential anti-inflammatory and antiatherosclerotic effects of gliptins have been reported. Our aim was to investigate whether saxagliptin treatment modifies expression of inflammatory markers, primarily in peripheral blood mononuclear cells (PBMCs) and in circulating leukocytes in patients with stable coronary artery disease (CAD) and T2DM. Methods. Patients (n=12) were randomized to saxagliptin 5 mg daily or placebo for 3 months. Samples were taken at baseline and end of study in fasting state prior to intake of medications. PBMCs were isolated and cryopreserved at −150°C until ex vivo exposed to 1 ng/mL of lipopolysaccharide (LPS) for 4 hours. Gene expression was performed with custom-designed TaqMan® Arrays and relative quantification by real-time PCR (RT-qPCR). Results. HbA1c was reduced in the saxagliptin-treated group compared to that in the change with placebo (p=0.042). In unstimulated PBMCs and in circulating leukocytes, we observed a significant increase in IL-10 expression in the saxagliptin group (p=0.043, both), significantly different from that in the placebo (p=0.009 and p=0.032, resp.). No between group differences in changes were observed in any of the selected proinflammatory markers. Conclusion. In our small cohort of patients with combined T2DM and CAD, a possible anti-inflammatory effect of saxagliptin, observed in the present study by upregulation of IL-10 in leukocytes, needs to be confirmed in larger studies.

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