scholarly journals Non-Autogenous Innovative Reconstruction Method Following Mandibulectomy

Medicina ◽  
2020 ◽  
Vol 56 (7) ◽  
pp. 326
Author(s):  
Bahaa Haj Yahya ◽  
Eli Rosenfeld ◽  
Gavriel Chaushu ◽  
Ilana Kaplan ◽  
Yehonantan Ben-Zvi ◽  
...  
Keyword(s):  
Autogenous Bone ◽  
Bone Block ◽  
Reconstruction Method ◽  
Bone Maturation ◽  
Reconstruction Procedure ◽  
Allogenic Bone ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Unique Manner ◽  
Anterior Mandible

Plexiform ameloblastoma is a locally aggressive odontogenic tumor, rare in the anterior mandible. The treatment of choice is resection with 1–3 cm free margins. In most of reported cases, the affected mandible is reconstructed by autogenic bone graft or osseocutaneous microvascular free flap in order to return function and esthetics. Case description: A 2 cm diameter exophytic ameloblastoma, located in the anterior mandible of a 50-year-old male was resected and reconstructed in a unique manner—allogenic bone block, recombinant human bone morphogenetic protein (rhBMP) and xenograft particles via transcutaneous submental approach. After bone maturation, dental implants were placed and restored by fixed prosthetics. Practical implications: Mandible reconstruction modalities have a crucial influence on patient quality of life, function and esthetics. Allogenic bone block combined with rhBMP and xenograft particles can replace the traditional autogenous bone in certain circumstances. A submental transcutaneous “tent pole” approach can improve the success rate of the reconstruction procedure.

Bone Regeneration around Dental Implants as a Treatment for Peri-Implantitis: A Review of the Literature

2011 ◽  
Vol 11 ◽  
pp. 21-33 ◽  
Author(s):  
Karthikeyan Subramani ◽  
Reji Mathew ◽  
Hossein Hosseinkhani ◽  
Mohsen Hosseinkhani
Keyword(s):  
Bone Regeneration ◽  
Dental Implants ◽  
Bone Morphogenetic Protein 2 ◽  
Surgical Approaches ◽  
Autogenous Bone ◽  
Implant Surface ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Bone Substitute Materials ◽  
Substitute Materials

This manuscript discusses peri-implantitis around dental implants and the current methodologies of surgical and non-surgical approaches towards treating peri-implantitis. Mechanical, chemical cleansing and reactivation of infected implant surface along with recent advances like the use of Laser and Photodynamic therapy (PDT) have also been reviewed in this literature. Bone regenerative treatment methods for the treatment of peri-implantitis using non-resorbable membranes (Guided Bone Regeneration), autogenous bone grafts and bone substitute materials with recombinant human bone morphogenetic protein-2 (rhBMP-2) and other growth factors have also been reviewed in this manuscript.

scholarly journals A Clinical Study on the Effect of Different Ratios of Recombinant Human Bone Morphogenetic Protein-2 Compound to Autogenous Bone on Cervical Interbody Fusion Based on Smart Healthcare

2021 ◽  
Vol 2021 ◽  
pp. 1-6
Author(s):  
Xinzhu Zhang ◽  
Kun Zhao ◽  
Feng Yuan ◽  
Youlai Yu ◽  
Bin Deng
Keyword(s):  
Bone Morphogenetic Protein ◽  
Interbody Fusion ◽  
Human Bone ◽  
Bone Morphogenetic Protein 2 ◽  
Autogenous Bone ◽  
Morphogenetic Protein ◽  
Human Bone Morphogenetic Protein ◽  
Group A ◽  
Group B ◽  
Recombinant Human Bone

With an increasing elderly population worldwide, the incidence of spine degenerative diseases with neck and shoulder pain as the main symptom is rising obviously, which has now become one of the important and difficult problems in sociomedical science. This study was to explore the effects of different ratios of recombinant human bone morphogenetic protein-2 (rhBMP-2) compound to the autogenous bone on cervical interbody fusion. 90 cervical degeneration patients with the need of surgical treatment admitted to our hospital from January 2019 to January 2020 were selected as the research objects and equally divided into group A, group B, and group C according to the order of admission, with 30 cases in each group and the ratios of rhBMP-2 compound to autogenous bone being 2 : 1, 1 : 1, and 1 : 2 respectively, and standard anterior cervical diskectomy and fusion (ACDF) treatment was performed to all patients to compare their surgery-related indexes, the Japanese Orthopaedic Association (JOA) score, the visual analog scale (VAS) score, the effect of cervical interbody fusion, and the postoperative complication rate (CR). Compared with group A and group C, group B achieved the significantly better surgery-related indexes ( P < 0.05 ), significantly higher postoperative JOA scores ( P < 0.05 ), significantly lower postoperative neck and upper limb VAS scores ( P < 0.05 ), significantly better effect of cervical interbody fusion ( P < 0.05 ), and significantly lower postoperative CR ( P < 0.05 ). 1 : 1 is the best ratio of rhBMP-2 compound to the autogenous bone, for it can optimize patients’ perioperative indexes, reduce the postoperative pain, lower the possibility of complications, and improve the effect of cervical interbody fusion, which should be promoted and applied in practice.

scholarly journals Possible Treatment of Severe Bone Dehiscences Based on 3D Bone Reconstruction—A Description of Treatment Methodology

2021 ◽  
Vol 11 (21) ◽  
pp. 10299
Author(s):  
Marzena Dominiak ◽  
Sylwia Hnitecka ◽  
Cyprian Olchowy ◽  
Sebastian Dominiak ◽  
Tomasz Gedrange
Keyword(s):  
Soft Tissues ◽  
Alveolar Bone ◽  
Three Dimensional ◽  
Autogenous Bone ◽  
Bone Block ◽  
Allogeneic Bone ◽  
Bone Reconstruction ◽  
Radiographic Images ◽  
Clinical Observations ◽  
Anterior Mandible

Gingival recessions constitute serious limitations for effective interdisciplinary periodontal, orthodontic, and implant therapy. A proper bone morphology of the alveolar bone and soft tissues that cover it are interdependent. The regeneration procedures known to date are based on the use of autogenous bone, or its allogeneic, xenogeneic, or alloplastic substitutes. These substitutes are characterized by different osteogenesis potentials. No effective procedure for three-dimensional bone reconstruction for cases in which there is dentition with recessions has been described to date, especially in its vertical dimension. This article presents the patented method of the three-dimensional bone reconstruction of the anterior mandible with preserved dentition when using an allogeneic bone block, and also includes a case report with a 2-year follow-up as an example. Based on clinical observations, it was stated that the intended therapeutic effect was achieved. There was no recession, shallowing of the vestibule, signs of inflammation, or pathological mobility of the teeth in the area undergoing reconstruction. The radiographic images revealed the formation of a new layer of cortical bone on the vestibular side and a certain volume of cancellous bone. No radiological demarcation zone of brightening, which indicates an incomplete adaptation, integration, and reconstruction of the bone block, was found.

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