scholarly journals High-Resolution CT Findings of Myositis-Related Interstitial Lung Disease

Medicina ◽  
2021 ◽  
Vol 57 (7) ◽  
pp. 692
Author(s):  
Ryoko Egashira
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Random Distribution ◽  
Diffuse Alveolar Damage ◽  
Lower Lobe ◽  
Trna Synthetase ◽  
Ground Glass ◽  
Acute Type ◽  
Aminoacyl Trna Synthetase ◽  
Nonspecific Interstitial Pneumonia

Myositis-related interstitial lung disease presents with a wide variety of lesions, ranging from chronic to acute. It can be divided into two main forms by the types of onsets, namely, chronic to subacute type showing nonspecific interstitial pneumonia (NSIP) or NSIP with an organizing pneumonia (OP)/ fibrosing OP (FOP) pattern and acute type showing acute lung injury (ALI) to diffuse alveolar damage (DAD) pattern. Anti-aminoacyl tRNA Synthetase antibody-positive cases mainly show an NSIP or FOP pattern, whereas anti-melanoma differentiation-associated gene 5 antibody-positive cases show ALI to DAD pattern. Bilateral consolidation with or without ground-glass opacification with lower lobe predominance is common as a major pattern in all types, but the distribution or extent is sometimes different. The early detection of findings that indicate a rapid progressive course is vital. Diffuse cranio-caudal distribution and multiple ground-glass opacifications with random distribution might indicate a poorer prognosis.

scholarly journals Predictive Factors for the Long-Term Deterioration of Pulmonary Function in Interstitial Lung Disease Associated with Anti-Aminoacyl-tRNA Synthetase Antibodies

Respiration ◽  
2018 ◽  
Vol 96 (3) ◽  
pp. 210-221 ◽  
Author(s):  
Hideaki Yamakawa ◽  
Eri Hagiwara ◽  
Hideya Kitamura ◽  
Tae Iwasawa ◽  
Ryota Otoshi ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Pulmonary Function ◽  
Lung Disease ◽  
Predictive Factors ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase

Predictive factors for the recurrence of anti-aminoacyl-tRNA synthetase antibody-associated interstitial lung disease

2020 ◽  
Vol 58 (2) ◽  
pp. 83-90 ◽  
Author(s):  
Reoto Takei ◽  
Yasuhiko Yamano ◽  
Kensuke Kataoka ◽  
Toshiki Yokoyama ◽  
Toshiaki Matsuda ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Predictive Factors ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase

Influence of obesity in interstitial lung disease associated with anti-aminoacyl-tRNA synthetase antibodies

2022 ◽  
pp. 106741
Author(s):  
Koichi Yamaguchi ◽  
Yasuhiro Fukushima ◽  
Aya Yamaguchi ◽  
Miki Itai ◽  
Yuki Shin ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase

scholarly journals Radiological diagnosis of interstitial lung diseases

2013 ◽  
Vol 66 (suppl. 1) ◽  
pp. 29-33
Author(s):  
Ruza Stevic ◽  
Vucinic Mihailovic ◽  
Dragana Jovanovic ◽  
Nada Vasic
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Interstitial Pneumonia ◽  
Lung Diseases ◽  
Usual Interstitial Pneumonia ◽  
Interstitial Lung Diseases ◽  
Ground Glass ◽  
Cryptogenic Organizing Pneumonia ◽  
Acute Interstitial Pneumonia ◽  
Nonspecific Interstitial Pneumonia

Introduction. Interstitial lung diseases include the entities of idiopathic pulmonary fibrosis, nonspecific interstitial pneumonia, cryptogenic organizing pneumonia, acute interstitial pneumonia, respiratory bronchiolitis-associated interstitial lung disease, desquamative interstitial pneumonia, and lymphocytic interstitial pneumonia. Recent introduction of high-resolution computed tomography has made the diagnosis of interstitial lung disease much easier. Usual interstitial pneumonia A predominantly subpleural reticulation and honeycombing at the basal posterior part of the lung with a progression to anterior and superior parts are characteristic of usual interstitial pneumonia/ idiopathic pulmonary fibrosis. Nonspecific interstitial pneumonia Typical findings of nonspecific interstitial pneumonia are bilateral, relatively symmetrical subpleural ground glass opacifications and irregular linear opacities. Desquamative interstitial pneumonia is characterized by diffuse symmetrical ground glass opacifications. Respiratory bronchiolitisassociated interstitial lung disease Centrilobular nodules and irregular ground glass opacifications are present. Cryptogenic organizing pneumonia Subpleural and peribronchial consolidations are prominent findings that are not present in other idiopathic interstitial pneumonias. Acute interstitial pneumonia. Bilateral ground-glass opacifications are present and areas of peripheral consolidations may also be seen in acute interstitial pneumonia. Lymphocytic interstitial pneumonia. Diffuse or patchy areas of ground glass opacification with centrilobular nodules and occasionally well-defined cysts are seen. Conclusion. Imaging plays a crucial role in identifying interstitial lung diseases but precise diagnosis requires a dynamic interdisciplinary approach that correlates clinical, radiological and pathologic features.

scholarly journals The long-term outcome of interstitial lung disease with anti-aminoacyl-tRNA synthetase antibodies

2017 ◽  
Vol 127 ◽  
pp. 57-64 ◽  
Author(s):  
Kiminobu Tanizawa ◽  
Tomohiro Handa ◽  
Ran Nakashima ◽  
Takeshi Kubo ◽  
Yuji Hosono ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Lung Disease ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
Term Outcome ◽  
Long Term Outcome

scholarly journals Efficacy of Glucocorticoids and Calcineurin Inhibitors for Anti-aminoacyl-tRNA Synthetase Antibody–positive Polymyositis/dermatomyositis–associated Interstitial Lung Disease: A Propensity Score–matched Analysis

2019 ◽  
Vol 46 (5) ◽  
pp. 509-517 ◽  
Author(s):  
Hironao Hozumi ◽  
Tomoyuki Fujisawa ◽  
Ran Nakashima ◽  
Hideki Yasui ◽  
Yuzo Suzuki ◽  
...  
Keyword(s):  
Interstitial Lung Disease ◽  
Propensity Score ◽  
Lung Disease ◽  
Survival Rates ◽  
Calcineurin Inhibitors ◽  
Trna Synthetase ◽  
Aminoacyl Trna Synthetase ◽  
First Line ◽  
First Line Therapy ◽  
Line Therapy

Objective.The optimal treatment strategy for anti-aminoacyl-tRNA synthetase antibody–positive polymyositis/dermatomyositis-associated interstitial lung disease (anti-ARS-PM/DM-ILD) is yet to be established. We aimed to evaluate the efficacy of glucocorticoids and calcineurin inhibitors (CNI) in patients with ARS-PM/DM-ILD.Methods.Progression-free survival (PFS) and overall survival rates were retrospectively evaluated in 32 consecutive patients with ARS-PM/DM-ILD. Disease progression was defined as deterioration in PM/DM-ILD (including recurrence). Predictive factors associated with PFS were analyzed by Cox hazards analysis. The efficacy of first-line prednisolone (PSL) plus CNI therapy was compared with that of PSL monotherapy using propensity score–matched analysis.Results.Overall, 20 (62.5%) and 12 (37.5%) patients received first-line therapy with PSL + CNI and PSL, respectively. The 2-year PFS and 5-year survival rates in the overall cohort were 68.8% and 96.9%, respectively. On multivariate analysis, arterial oxygen pressure (HR 0.86) and PSL monotherapy (vs PSL + CNI; HR 7.29) showed an independent association with PFS. Baseline characteristics of propensity score-matched PSL + CNI and PSL groups were similar. The 2-year PFS rate was significantly higher in the matched PSL + CNI group than in the matched PSL group. All patients who experienced disease progression during first-line therapy were subsequently treated with second-line therapies. The 5-year survival rates of both the matched PSL + CNI and PSL groups were favorable.Conclusion.Propensity score–matched analysis demonstrated that first-line PSL + CNI therapy for patients with ARS-PM/DM-ILD significantly improved the PFS compared with PSL monotherapy, although there was no significant difference regarding longterm survival.

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