scholarly journals Hemorheological Parameters in Diabetic Patients: Role of Glucose Lowering Therapies

Metabolites ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 806
Author(s):  
Katalin Biro ◽  
Gergely Feher ◽  
Judit Vekasi ◽  
Peter Kenyeres ◽  
Kalman Toth ◽  
...  

Diabetes mellitus influences several important hemorheological parameters including blood viscosity, erythrocyte aggregation and deformability. In the present study, 159 type-2 diabetic patients and 25 healthy controls were involved. Patient’s age, body weight, body mass index (BMI), smoking habits, physical activity, history of cardiovascular diseases, current antidiabetic therapy and concomitant medication were recorded. Patients were grouped according to their antidiabetic treatment with insulin, or with one or more of the following antidiabetic drugs: metformin, sulfonylureas, acarbose, or no antidiabetic therapy. Hemorheological measurements (hematocrit, erythrocyte aggregation, plasma fibrinogen, whole blood and plasma viscosity), von Willebrand factor activity, and platelet aggregation measurements were performed. Platelet aggregation was investigated with the method of Born. Plasma viscosity and red blood cell aggregation were significatly higher in diabetes. No significant difference was found in hemorheological parameters between different antidiabetic regimens. Whole blood and plasma viscosity and red blood cell aggregation correlated with glucose levels but not with HbA1C levels. In conclusion, plasma and whole blood viscosity, as well as red blood cell aggregation appear to be associated with concurrent hyperglycemia, but not with the quality of glycemic control or the applied antidiabetic treatment. Platelet aggregation induced by ADP or epinephrine does not seem to be associated with diabetes even at subthreshold doses.

2013 ◽  
Vol 12 (5) ◽  
pp. 5-12
Author(s):  
M. N. Azhermacheva ◽  
D. M. Plotnikov ◽  
O. I. Aliev ◽  
V. M. Alifirova ◽  
M. B. Plotnikov ◽  
...  

The study evaluated the rheological parameters of blood: blood viscosity, plasma viscosity, hematocrit, red blood cell aggregation and deformability. The severity of the patients was assessed by clinical scales:Glasgowcoma scale, the scale NIHSS, Barthel index. The study found that in the acute phase of ischemic stroke increased blood viscosity by increasing red blood cell aggregation and reduced erythrocyte deformability. The increase in the viscosity of the blood in acute ischemic stroke is accompanied by increased severity of neurological disorders.


2002 ◽  
Vol 19 (2) ◽  
pp. 152-156 ◽  
Author(s):  
K. Elishkevitz ◽  
R. Fusman ◽  
M. Koffler ◽  
I. Shapira ◽  
D. Zeltser ◽  
...  

2001 ◽  
Vol 280 (1) ◽  
pp. H222-H236 ◽  
Author(s):  
Jeffrey J. Bishop ◽  
Patricia R. Nance ◽  
Aleksander S. Popel ◽  
Marcos Intaglietta ◽  
Paul C. Johnson

A recent whole organ study in cat skeletal muscle showed that the increase in venous resistance seen at reduced arterial pressures is nearly abolished when the muscle is perfused with a nonaggregating red blood cell suspension. To explore a possible underlying mechanism, we tested the hypothesis that red blood cell aggregation alters flow patterns in vivo and leads to blunted red blood cell velocity profiles at reduced shear rates. With the use of fluorescently labeled red blood cells in tracer quantities and a video system equipped with a gated image intensifier, we obtained velocity profiles in venous microvessels (45–75 μm) of rat spinotrapezius muscle at centerline velocities between 0.3 and 14 mm/s (pseudoshear rates 3–120 s−1) under normal (nonaggregating) conditions and after induction of red blood cell aggregation with Dextran 500. Profiles are nearly parabolic (Poiseuille flow) over this flow rate range in the absence of aggregation. When aggregation is present, profiles are parabolic at high shear rates and become significantly blunted at pseudoshear rates of 40 s−1 and below. These results indicate a possible mechanism for increased venous resistance at reduced flows.


2009 ◽  
Vol 37 (11) ◽  
pp. 2299-2309 ◽  
Author(s):  
Marianne Fenech ◽  
Damien Garcia ◽  
Herbert J. Meiselman ◽  
Guy Cloutier

In this article, the authors draw attention of readers to the capabilities of the conjunctival microscopy (CM) the method for studying the processes of vascular permeability and microhemorheology in patients with systemic sclerosis (SS). An original simultaneous examination of 48 patients with SS (mean age 51±1,7 years) and a comparable age group (4,74±2,3 years) of the control group of people without any diseases that might affect microcirculation (MC) by the CM-method was performed. The results demonstrated high informativeness of the CM-method in the diagnostics and assessment of vascular permeability and intravascular red blood cell aggregation (RBCA) in SS. The main changes in MC during SS revealed by the CM-method are the increase in vascular permeability and enhancement of RBCA in all types of microvessels. Key words: vascular permeability, intravascular red blood cell aggregation, conjunctival microscopy, systemic sclerosis.


1991 ◽  
Vol 11 (6) ◽  
pp. 649-654
Author(s):  
C. Fossat ◽  
P. Bonitchi ◽  
P. Vague ◽  
M. Mirshahi ◽  
J. Soria ◽  
...  

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