Optical Fiber Tweezers: A Versatile Tool for Optical Trapping and Manipulation

Optical trapping is widely used in different areas, ranging from biomedical applications, to physics and material sciences. In recent years, optical fiber tweezers have attracted significant attention in the field of optical trapping due to their flexible manipulation, compact structure, and easy fabrication. As a versatile tool for optical trapping and manipulation, optical fiber tweezers can be used to trap, manipulate, arrange, and assemble tiny objects. Here, we review the optical fiber tweezers-based trapping and manipulation, including dual fiber tweezers for trapping and manipulation, single fiber tweezers for trapping and single cell analysis, optical fiber tweezers for cell assembly, structured optical fiber for enhanced trapping and manipulation, subwavelength optical fiber wire for evanescent fields-based trapping and delivery, and photothermal trapping, assembly, and manipulation.

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One drop at a time: toward droplet microfluidics as a versatile tool for single-cell analysis

NPG Asia Materials ◽

10.1038/am.2014.86 ◽

2014 ◽

Vol 6 (10) ◽

pp. e133-e133 ◽

Cited By ~ 67

Author(s):

Agata Rakszewska ◽

Jurjen Tel ◽

Venkatachalam Chokkalingam ◽

Wilhelm TS Huck

Keyword(s):

Single Cell ◽

Single Cell Analysis ◽

Droplet Microfluidics ◽

Cell Analysis ◽

Versatile Tool

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Integrating Optical Fiber Bridges in Microfluidic Devices to Create Multiple Excitation/Detection Points for Single Cell Analysis

Analytical Chemistry ◽

10.1021/acs.analchem.6b03133 ◽

2016 ◽

Vol 88 (20) ◽

pp. 9920-9925 ◽

Cited By ~ 9

Author(s):

Damith E. W. Patabadige ◽

Jalal Sadeghi ◽

Madumali Kalubowilage ◽

Stefan H. Bossmann ◽

Anne H. Culbertson ◽

...

Keyword(s):

Optical Fiber ◽

Single Cell ◽

Single Cell Analysis ◽

Microfluidic Devices ◽

Cell Analysis

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Translating vibrational spectroscopy into clinical applications – vision or reality?

Faraday Discussions ◽

10.1039/c6fd00108d ◽

2016 ◽

Vol 187 ◽

pp. 603-607 ◽

Cited By ~ 3

Author(s):

Wolfgang Petrich

Keyword(s):

Vibrational Spectroscopy ◽

Biomedical Applications ◽

Single Cell Analysis ◽

Academic Research ◽

Optical Resolution ◽

Analysis Data ◽

Diagnostic Value ◽

Cell Analysis ◽

Data Analysis Procedure

The Faraday Discussion meeting “Advanced Vibrational Spectroscopy for Biomedical Applications” provided an excellent opportunity to share and discuss recent research and applications on a highly interdisciplinary level. Spectral pathology, single cell analysis, data handling, clinical spectroscopy, and the spectral analysis of biofluids were among the topics covered during the meeting. The focus on discussion rather than “merely” presentation was highly appreciated and fruitful discussions evolved around the interpretation of the amide-bands, optical resolution, the role of diffraction and data analysis procedure, to name a few. The meeting made clear that the spectroscopy of molecular vibrations in biomolecules has evolved from a purely academic research tool to a technology used in clinical practice in some cases. In this sense, biomedical vibrational spectroscopy has reached a pivotal point at which questions like diagnostic value, therapeutic consequence and financial viability are gaining more and more importance.

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Optical Fiber Tweezers for the Assembly of Living Photonic Probes

10.5772/intechopen.98845 ◽

2021 ◽

Author(s):

Xing Li ◽

Hongbao Xin

Keyword(s):

Optical Fiber ◽

Optical Detection ◽

Living Cells ◽

Great Promise ◽

Biological Cells ◽

Cell Trapping ◽

Versatile Tool ◽

Biological Environment ◽

Multiple Cells ◽

Significant Attention

Optical fiber tweezers, as a versatile tool for optical trapping and manipulation, have attracted much attention in cell trapping, manipulation, and detection. Particularly, assembly of living cells using optical fiber tweezes has become a significant attention. Advanced achievements have been made on the assembly of fully biocompatible photonic probes with biological cells, enabling optical detection in biological environment in a highly compatible manner. Therefore, in this chapter, we discuss the use of optical fiber tweezers for assembly of living photonic probes. Living photonic probes can be assembled by the trapping and assembly of multiple cells using optical fiber tweezers. These photonic probes exhibit high biocompatibility and show great promise for the bio-applications in bio-microenvironments.

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Advanced Top-Down Fabrication for a Fused Silica Nanofluidic Device

Micromachines ◽

10.3390/mi11110995 ◽

2020 ◽

Vol 11 (11) ◽

pp. 995

Author(s):

Kyojiro Morikawa ◽

Yutaka Kazoe ◽

Yuto Takagi ◽

Yoshiyuki Tsuyama ◽

Yuriy Pihosh ◽

...

Keyword(s):

Single Cell ◽

Single Cell Analysis ◽

Fused Silica ◽

Cell Analysis ◽

Top Down ◽

Silica Substrate ◽

Single Substrate ◽

Nanofluidic Devices ◽

Nanofluidic Device ◽

Significant Attention

Nanofluidics have recently attracted significant attention with regard to the development of new functionalities and applications, and producing new functional devices utilizing nanofluidics will require the fabrication of nanochannels. Fused silica nanofluidic devices fabricated by top-down methods are a promising approach to realizing this goal. Our group previously demonstrated the analysis of a living single cell using such a device, incorporating nanochannels having different sizes (102–103 nm) and with branched and confluent structures and surface patterning. However, fabrication of geometrically-controlled nanochannels on the 101 nm size scale by top-down methods on a fused silica substrate, and the fabrication of micro-nano interfaces on a single substrate, remain challenging. In the present study, the smallest-ever square nanochannels (with a size of 50 nm) were fabricated on fused silica substrates by optimizing the electron beam exposure time, and the absence of channel breaks was confirmed by streaming current measurements. In addition, micro-nano interfaces between 103 nm nanochannels and 101 μm microchannels were fabricated on a single substrate by controlling the hydrophobicity of the nanochannel surfaces. A micro-nano interface for a single cell analysis device, in which a nanochannel was connected to a 101 μm single cell chamber, was also fabricated. These new fabrication procedures are expected to advance the basic technologies employed in the field of nanofluidics.

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