Three classes of epigenomic regulators converge to hyperactivate the essential maternal gene deadhead within a heterochromatin mini-domain

The formation of a diploid zygote is a highly complex cellular process that is entirely controlled by maternal gene products stored in the egg cytoplasm. This highly specialized transcriptional program is tightly controlled at the chromatin level in the female germline. As an extreme case in point, the massive and specific ovarian expression of the essential thioredoxin Deadhead (DHD) is critically regulated in Drosophila by the histone demethylase Lid and its partner, the histone deacetylase complex Sin3A/Rpd3, via yet unknown mechanisms. Here, we identified Snr1 and Mod(mdg4) as essential for dhd expression and investigated how these epigenomic effectors act with Lid and Sin3A to hyperactivate dhd. Using Cut&Run chromatin profiling with a dedicated data analysis procedure, we found that dhd is intriguingly embedded in an H3K27me3/H3K9me3-enriched mini-domain flanked by DNA regulatory elements, including a dhd promoter-proximal element essential for its expression. Surprisingly, Lid, Sin3a, Snr1 and Mod(mdg4) impact H3K27me3 and this regulatory element in distinct manners. However, we show that these effectors activate dhd independently of H3K27me3/H3K9me3, and that dhd remains silent in the absence of these marks. Together, our study demonstrates an atypical and critical role for chromatin regulators Lid, Sin3A, Snr1 and Mod(mdg4) to trigger tissue-specific hyperactivation within a unique heterochromatin mini-domain.

School Drug Education and Leadership Agility: Narcotics Crime Study in Children

The study aimed to examine school drug education and agile leadership and lawlessness factors in children involving adults. This report led to a study on child narcotics crimes. 17 district court decisions from 2017-2020 are the unit of analysis, using the Question Nvivo-12 plus software process. The aim of using Nvivo-12 plus is to analyze data with a data coding model. In addition, the writers also interviewed main witnesses, including judges who prosecuted child narcotics cases. . The data analysis procedure includes a validity test using triangulation of sources, time, and place. Grouping of data in the form of images and tables that have been processed for analysis with three data analysis techniques through percentages, making explanations, and comparing with theories or previous research results. According to the findings of the study, drugs education for youngsters involved in narcotics cases is critical. Furthermore, economic constraints, unsatisfactory home conditions, invites from acquaintances, and the influence of social media are all variables that lead to children committing narcotics offenses. In addition to these factors, the authors also found something new that makes children entangled in narcotics crimes, namely the involvement of adults who use children in the narcotics trade. For these factors, agile leadership is need, especially adult leaders with sensitivity, leadership unity, and quality of optimizing resources to protect children from the effects of drug abuse and the need to build particular educational institutions for children involved in crime. So children are given adequate education and skills, so they are not entangled again in drug cases.. Keywords: Drug Education, Violation of The Law, Criminal Act, Leadership Agility

TEACHING FACTORS THAT AFFECT STUDENTS’ LEARNING MOTIVATION: BANGLADESHI EFL STUDENTS’ PERCEPTIONS

Research literature consistently suggests that EFL (English as a foreign language) students’ motivation is affected by some teaching factors (Falout et al., 2009; Kim et al., 2018; Lamb, 2017). The main purpose of this study is to identify exactly which teaching factors adversely affect students’ motivation to study English at higher secondary (HS) level (grade 11 and 12) in Bangladeshi EFL context. To collect qualitative data an interview protocol was developed based on the teaching factors identified in some selected studies conducted in Asian EFL contexts (Kikuchi, 2009; Sakai & Kikuchi, 2009; Trang & Baldauf, 2007; Quadir, 2017). A total number of 40 grade 12 completers were interviewed to collect students’ perceptions. Miles and Huberman’s (1994) qualitative data analysis procedure was applied to analyze the data. From the analysis five distinct factors, which adversely affect students’ motivation, are identified in descending order: teachers’ instructional styles and teaching method, private tutoring, teachers’ personality and behavior, teachers’ competence and classroom management, and teachers’ attitude and commitment. Most of these factors comprise further sub-components which detect the underlying sources of students’ disinterest. For amelioration of the situations some feasible implications are discussed addressing the identified factors.

The Challenges Faced By Educators in Online Teaching during the Covid-19 Pandemic Outbreak

Since the pandemic attack the whole world, various research has been conducted related to the challenges of online learning. Focus has always been on the issues faced by the students, but lack of research has been to done from the educators’ perspective. Therefore, this research aims to identify the issues and challenges faced by the educators in online teaching. The issues that the researchers identified are technology, lack of training and lack of tools and materials make it difficult for the educators to adapt with the changes from teaching in the physical classroom to a virtual classroom which exposes the educators to a new teaching environment and this imposed countless challenges. The research method that is used in this research is simple random sampling where the sample size of this study is around 30 educators which focus on the educators that engage in online teaching at the age range between 21 years old until 60 years old. The data was collected through a questionnaire and the questionnaire is divided into three different sections. The data analysis procedure used in this research is frequency analysis to offer the researcher to analyze the data of the questionnaire. It was identified majority of the respondents are facing challenges with online teaching which decrease their motivation and productivity and contribute to low satisfaction and outcomes in their delivery of lectures.

Purchase Decision in Terms of Price and Trust Aspects

Indonesia, as a country with the highest e-commerce growth globally. There is much e-commerce emerging in Indonesia, which proves online stores. One of them is Shopee. Shopee is an online-based shopping platform that provides various sales products ranging from electronics, household goods, clothing, fashion accessories. Shopee was founded in 2015 and is part of the SEA GROUP operating in Southeast Asia. This study is as follows to analyze the effect of price perception and trust on online purchasing decisions at shopee in Mataram. The type of research used in this research is causal research. The sample in this study is 100 Shopee users who have repeatedly used Shopee services as an online purchase. The data collection tool used in this research is a questionnaire. The data analysis procedure used Multiple Linear Regression Analysis. The result showed that : (1) There is a significant influence of price perception on Purchase Decision at Shopee during the Pandemic of Covid 2019 in the Mataram Region. (2) There is a significant influence of trust on Purchase decisions at Shopee during the Pandemic of Covid 2019 in the Mataram Region.

Teaching Reading Through KWL (Know-Want to know-Learned) Strategy In Islamic Economics Text

KWL strategy is a reading strategy used by teachers or educators to improve the students' reading skills by activating their prior knowledge, encouraging their motivation, and making the student comprehend the text holistically. The purpose of this research is to (1) apply the K-W-L Strategy in Reading Islamic Economics Text (2) know How do the students apply the K-W-L strategy in reading Islamic economics text. This research is conducted in a descriptive qualitative design. The data is collected by observation and documents. Data analysis procedure based on Creswell, Rossman & Marshall, 1) Organizing and familiarizing 2) Coding and reducing 3) Interpreting and representing. The results present that the application of K-W-L strategy is made through three steps, namely 1) Pre-reading, where the teacher or researcher created a good condition of the classroom and introducing passage, and the students filling the chart in K column 2) Whilst reading, the teacher leads the student read the text and started to write down what they want to learn in W column 3) Post-reading in which the students started to comprehend the passage, make a conclusion and stated what they have learned from text based on their comprehension in L column. The study also concluded that the KWL strategy was appropriate in teaching reading on Islamic Economics Text, and it can be applied in reading for any level of English learners.

Methodology Section of Graduate School Thesis Manuscripts: A Genre Analysis Probe of Rhetorical Structure

The methodology section of thesis manuscripts is one of the important parts that should be well written. From this premise, a genre analysis was conducted to 30 Master of Arts in Language Teaching (MALT-English) research articles of the Graduate School in University of Southern Mindanao (USM). The study aimed to determine the rhetorical move structure and the moves that dominate in the methodology section of the said research articles. Results revealed that the methodology section has 5 moves with corresponding steps. These include Move 1: Introducing the Method chapter; Move 2: Presenting the Design of the Study; Move 3: Describing data collection method; Move 4: Clarifying Data Analysis Procedure; and Move 5. Establishing the ethical considerations and trustworthiness of the study. Obligatory steps identified are Pointing out the research design used in the study under Move 2, Presenting the Design of the Study; Describing the locale, participants/respondents and data source/research materials and research instrument/s; and Describing methods and steps in data collection under move 3, data collection method. While the moves are similar in 30 articles, there are steps which are interchanged and are either evident or not evident in some articles. This implied that writers employ varied steps in writing the methodology section even if they are of similar discipline.

Religiusitas dalam Novel Maharku Surah Ar-Rahman Karya Ahliya Mujahidin

Menikah merupakan salah satu bentuk ibadah muamallah. Pernikahan yang sesuai dengan ajaran Islam ialah perkawinan tanpa lewat proses pacaran, dikenal dengan ta’ aruf. Taaruf ialah proses perkenalan untuk mengetahui calon istri atau suami sebelum memasuki jenjang pernikahan. Taaruf sebagai bentuk perjodohan melalui mediator atau perantara yang mempertemukan kedua belah pihak calon pasangan. Riset ini bertujuan untuk mendeskripsikan nilai-nilai religiusitas yang berhubungan dengan muamalah ataupun interaksi/ jalinan antara manusia dengan manusia (Hablumminannas) dalam novel Maharku Surah Ar-Rahman karya Ahliya Mujahidin. Fokus penelitian ini adalah nilai-nilai religious yang terdapat dalam novel Maharku Surah Ar-rahman yang berhubungan dengan pernikahan dalam Islam. Prosedur analisis data yang digunakan dalam riset ini yakni interpretasi serta uraian konten. Sumber data dalam riset ini suatu novel yang bertajuk Maharku Surah Ar-Rahman karya Ahliya Mujahidin yang diterbitkan oleh Razka Pustaka tahun 2020. Berdasarkan analisis data yang dilakukan, terdapat nilai religius yang berhubungan dengan ibadah muamallah (Hablumminnas) dalam aspek perkawinan, yaitu sebuah pernikahan yang diawali dengan perkenalan melaui perantara atau perjodohan (taaruf) lalu dilanjutkan dengan pertunagan (khitbah) hingga prosesi ijab-kabul yang sesuai dengan ajaran agama Islam. Getting married is a form of muamallah worship. Marriage by Islamic teachings is marriage without going through the process of dating, known as ta ‘aruf. Ta ‘aruf is an introductory process to find out a prospective wife or husband before entering a marriage. Taaruf is a form of matchmaking through a mediator or intermediary that brings together the two potential partners. This research aims to describe the values ​​of religiosity related to muamalah or the interaction/relationships between humans and humans (Hablumminannas) in the novel Maharku Surah Ar-Rahman by Ahliya Mujahidin. The focus of this research quotes that contain Islamic values ​​in the aspect of marriage based on Islamic concepts. The data analysis procedure used in this research is the interpretation and description of the content. The data source in this research is a novel entitled Maharku Surah Ar-Rahman by Ahliya Mujahidin published by Razka Pustaka in 2020. Based on the data analysis, there are religious values ​​related to the worship of muamallah (Hablumminnas) in the aspect of marriage, namely a marriage that begins with introductions through intermediaries or matchmaking (taaruf) and then continues with engagement (khitbah) until the consent procession is in accordance with the teachings of Islam.

KINERJA GURU DALAM IMPLEMENTASI KURIKULUM 2013 DI SMA ISLAM AL-MA’ARIF PANDAN INDAH KABUPATEN LOMBOK TENGAH PROVINSI NUSA TENGGARA BARAT

Teacher performance is a necessity in improving the quality of learning services which includes the implementation of the curriculum for all components of the learning eye. The curriculum is a collection; the contents, objectives, and methods used by the teacher to achieve educational goals in school. This study aims to determine the teacher's performance and the obstacles faced by ISLAM AL-MA'ARIF high school teachers Pandan Indah district Lombok Tengah province Nusa Tenggara Barat in the implementation of the 2013 curriculum. To achieve this goal, this study uses a descriptive qualitative approach. While the subjects of the study were school supervisors, principals, deputy principals in the curriculum, K-13 assistant teachers and subject teachers. Data collection techniques are carried out through interviews, observation, and documentation studies. The data analysis procedure is data reduction, data display, and data verification.