scholarly journals X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3253 ◽  
Author(s):  
Ioana Vlaicu ◽  
Gheorghe Borodi ◽  
Gina Scăețeanu ◽  
Mariana Chifiriuc ◽  
Luminița Măruțescu ◽  
...  

Five new copper(II) acrylate complexes (acr is the acrylate anion: C3H3O2) with imidazole derivatives (2-methylimidazole/2-MeIm, 5-methylimidazole/5-MeIm, 2-ethylimidazole/2-EtIm) of type: cis-[Cu(2-RIm)2(acr)2]·xH2O ((1): R = –CH3, x = 2; (4): R = –CH2–CH3, x = 0), trans-[Cu(2-RIm)2(acr)2] ((2): R = –CH3; (5): R = –CH2–CH3) and trans-[Cu(5-RIm)2(acr)2] ((3): R = –CH3) have been prepared and characterized by elemental analysis, Fourier Transform Infrared spectrometry (FTIR), Electron Paramagnetic Resonance (EPR), electronic reflectance spectroscopy, scanning electron microscopy, and mass spectrometry. The single crystal X-ray diffraction study of complexes (2) and (5) reveals that the copper(II) ion is located on an inversion center and show elongated octahedral geometry completed by two coplanar bidentate acrylates and two unidentate imidazole derivatives displayed in trans positions. For complex (4) the single crystal X-ray diffraction shows that the copper(II) ion is in a distorted octahedral environment which can be easily confused with a trigonal prism completed by two bidentate acrylates and two unidentate imidazole derivatives displayed in cis positions. These results indicate the fact that complexes (4) and (5) are the geometric isomers of the same compound bis(acrylate)-bis(2-ethylimidazole)-copper(II). Complexes (1) and (2), as well as (4) and (5), were produced simultaneously in the reaction of the corresponding copper(II) acrylate with imidazole derivatives in methanol solution. Furthermore, in order to be able to formulate potential applications of the obtained compounds, our next goal was to investigate the in vitro antimicrobial activity of the synthesized complexes against Gram-positive and Gram-negative bacteria, as well as fungal strains, of both clinical and ecological importance (biodeterioration of historical buildings). The trans isomers (2) and (5), followed by (4) have shown the broadest range of antimicrobial activity. In case of (1) and (2) isomers, the trans isomer (2) was significantly more active than cis (1), while the cis isomer (4) proved to be more active than trans (5). Taken together, the biological evaluation results indicate that the trans (2) was the most active complex, demonstrating its potential for the development of novel antimicrobial agents, with potential applications in the biomedical and restoration of architectural monuments fields.

2017 ◽  
Vol 41 (10) ◽  
pp. 4096-4109 ◽  
Author(s):  
X. Janet Sabina ◽  
J. Karthikeyan ◽  
Gunasekaran Velmurugan ◽  
M. Muthu Tamizh ◽  
A. Nityananda Shetty

Six chalcones were synthesized and their structures determined by single crystal X-ray diffraction studies. They exhibited enhanced anticancer activity and tubulin inhibition.


2011 ◽  
Vol 239-242 ◽  
pp. 2132-2136
Author(s):  
Xi Lan Hu ◽  
Qin Jiang ◽  
Xing You Xu

A novel mixed-ligand copper(II) complex [Cu(pht)2(phen)H2O] (Hpht = 5,5-diphenylimidazolidine-2,4-dione, phen = 1,10-phenanthroline) was has been synthesized solvent-thermally and characterized by elemental analysis, IRand single-crystal X-ray diffraction. The crystal of the copper complex belongs to Triclinic system with space group P1, a = 11.747(14), b = 12.639(15), c = 14.021(17)Å, α= 97.986(18)º, β= 104.958(18) º, γ= 108.485(19) º, V = 1851(4) Å3, Dc = 1.371 g/cm3, Z = 2, F(000) = 790, µ = 0.644mm-1, R1 = 0.0835, wR2= 0.1436 [I>2σ(I)] and GOF=0.867. The X-ray data showed that the Cu(II) atom adopted a distorted CuN2O3 square pyramidal configuration when coordinated with two phen ligands and one water ligand. The antimicrobial activity of the title complex was evaluated against a series of fungi or bacteria in vitro by agar method and the filter paper method, respectively.The results showed that the title complex was more active against the Fusarim gramine arum, Escherichia coli and Staphylococcus Aureus than its precursor Hpht and Cu(Ac)2×H2O.


2015 ◽  
Vol 10 (2) ◽  
pp. 1934578X1501000
Author(s):  
Yen-You Lin ◽  
Su-June Tsai ◽  
Michael Y. Chiang ◽  
Zhi-Hong Wen ◽  
Jui-Hsin Su

Chemical investigation of a crinoid Himerometra magnipinna has afforded three anthraquinones (1–3), including one new metabolite, (+)-rhodoptilometrin (1). The structures of these compounds were elucidated on the basis of their spectroscopic data and the absolute configuration of 1 was further confirmed by single-crystal X-ray diffraction analysis. In the in vitro anti-inflammatory effects test, compound 2 was found to significantly inhibit the accumulation of the pro-inflammatory iNOS protein of the LPS-stimulated RAW264.7 macrophage cells.


2018 ◽  
Vol 122 (2) ◽  
pp. 601-609 ◽  
Author(s):  
Ayelén Florencia Crespi ◽  
Agustín Jesús Byrne ◽  
Daniel Vega ◽  
Ana Karina Chattah ◽  
Gustavo Alberto Monti ◽  
...  

1999 ◽  
Vol 595 ◽  
Author(s):  
A.K. Sharma ◽  
C. Jin ◽  
A. Kvit ◽  
J. Narayan ◽  
J.F. Muth ◽  
...  

AbstractWe have synthesized single-crystal epitaxial MgZnO films by pulsed-laser deposition. High-resolution transmission electron microscopy, X-ray diffraction and Rutherford backscattering spectroscopy/ion channeling were used to characterize the microstructure, defect content, composition and epitaxial single-crystal quality of the films. In these films with up to ∼ 34 atomic percent Mg incorporation, an intense ultraviolet band edge photoluminescence at room temperature and 77 K was observed. The highly efficient photoluminescence is indicative of the excitonic nature of the material. Transmission spectroscopy revealed that the excitonic structure of the alloys was clearly visible at room temperature. Post-deposition annealing in oxygen reduced the number of defects and improved the optical properties of the films. The potential applications of MgZnO alloys in a variety of optoelectronic devices are discussed.


2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Zou Xun-Zhong ◽  
Feng An-Sheng ◽  
Zeng Fu-Ran ◽  
Lai Min-Cheng ◽  
Liao Yan-Zhi ◽  
...  

Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.


Author(s):  
Vinutha V. Salian ◽  
Badiadka Narayana ◽  
Balladka K. Sarojini ◽  
Madan S. Kumar ◽  
Govinahalli S. Nagananda ◽  
...  

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2405 ◽  
Author(s):  
Diana I. S. P. Resende ◽  
Patrícia Pereira-Terra ◽  
Joana Moreira ◽  
Joana Freitas-Silva ◽  
Agostinho Lemos ◽  
...  

A series of thirteen xanthones 3–15 was prepared based on substitutional (appendage) diversity reactions. The series was structurally characterized based on their spectral data and HRMS, and the structures of xanthone derivatives 1, 7, and 8 were determined by single-crystal X-ray diffraction. This series, along with an in-house series of aminated xanthones 16–33, was tested for in-vitro antimicrobial activity against seven bacterial (including two multidrug-resistant) strains and five fungal strains. 1-(Dibromomethyl)-3,4-dimethoxy-9H-xanthen-9-one (7) and 1-(dibromomethyl)-3,4,6-trimethoxy-9H-xanthen-9-one (8) exhibited antibacterial activity against all tested strains. In addition, 3,4-dihydroxy-1-methyl-9H-xanthen-9-one (3) revealed a potent inhibitory effect on the growth of dermatophyte clinical strains (T. rubrum FF5, M. canis FF1 and E. floccosum FF9), with a MIC of 16 µg/mL for all the tested strains. Compounds 3 and 26 showed a potent inhibitory effect on two C. albicans virulence factors: germ tube and biofilm formation.


2015 ◽  
Vol 13 (19) ◽  
pp. 5497-5509 ◽  
Author(s):  
Lan-Zhi Wang ◽  
Xiao-Qing Li ◽  
Ying-Shuang An

36 novel 1,5-benzodiazepine derivatives were synthesized and evaluated for their in vitro antimicrobial activity. The results revealed that most of the 1,5-benzodiazepine derivatives exhibited considerable potency against all of the tested strains.


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