Synthesis, Crystal Structure and Antimicrobial Activity of a Mixed-Ligand Copper (II) Complex [Cu(pht)2 (phen)H2O]

2011 ◽  
Vol 239-242 ◽  
pp. 2132-2136
Author(s):  
Xi Lan Hu ◽  
Qin Jiang ◽  
Xing You Xu
Keyword(s):  
Antimicrobial Activity ◽  
Mixed Ligand ◽  
Title Complex ◽  
Water Ligand ◽  
X Ray Diffraction ◽  
X Ray ◽  
Triclinic System ◽  
Pyramidal Configuration ◽  
Paper Method

A novel mixed-ligand copper(II) complex [Cu(pht)2(phen)H2O] (Hpht = 5,5-diphenylimidazolidine-2,4-dione, phen = 1,10-phenanthroline) was has been synthesized solvent-thermally and characterized by elemental analysis, IRand single-crystal X-ray diffraction. The crystal of the copper complex belongs to Triclinic system with space group P1, a = 11.747(14), b = 12.639(15), c = 14.021(17)Å, α= 97.986(18)º, β= 104.958(18) º, γ= 108.485(19) º, V = 1851(4) Å3, Dc = 1.371 g/cm3, Z = 2, F(000) = 790, µ = 0.644mm-1, R1 = 0.0835, wR2= 0.1436 [I>2σ(I)] and GOF＝0.867. The X-ray data showed that the Cu(II) atom adopted a distorted CuN2O3 square pyramidal configuration when coordinated with two phen ligands and one water ligand. The antimicrobial activity of the title complex was evaluated against a series of fungi or bacteria in vitro by agar method and the filter paper method, respectively．The results showed that the title complex was more active against the Fusarim gramine arum, Escherichia coli and Staphylococcus Aureus than its precursor Hpht and Cu(Ac)2×H2O.

scholarly journals Synthesis, Crystal Structures, and Antimicrobial and Antitumor Studies of Two Zinc(II) Complexes with Pyridine Thiazole Derivatives

2020 ◽  
Vol 2020 ◽  
pp. 1-9 ◽  
Author(s):  
Zou Xun-Zhong ◽  
Feng An-Sheng ◽  
Zeng Fu-Ran ◽  
Lai Min-Cheng ◽  
Liao Yan-Zhi ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Metal Salts ◽  
X Ray Diffraction ◽  
Antitumor Activities ◽  
Thiazole Derivatives ◽  
Monoclinic System ◽  
Bioactive Materials ◽  
X Ray ◽  
Microplate Reader

Two pyridine thiazole derivatives, namely, 4-(pyridin-2-yl)-2-(2-(pyridin-2-ylmethylene)hydrazinyl)thiazole (L1) and 4-(pyridin-3-yl)-2-(2-(pyridin-4-ylmethylene)hydrazinyl)thiazole (L2), were afforded by a cyclization reaction between α-haloketone and thioamide, and their Zn(II) complexes were prepared by the reaction of ligands and corresponding metal salts, respectively, and characterized by X-ray diffraction and elemental analysis. Both crystals were obtained by ether diffusion and crystallized in a monoclinic system. The in vitro antimicrobial activity of the Zn(II) complexes and ligands was screened using the microplate reader method, and in vitro antitumor activities of the complexes were evaluated by MTT, with a view to developing new improved bioactive materials with novel properties. The biological activity studies of the compounds showed that the metal complexes were more active than the free ligands, and some compounds had absolute specificity for certain bacteria or cancer cell lines.

scholarly journals Synthesis of a Small Library of Nature-Inspired Xanthones and Study of Their Antimicrobial Activity

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2405 ◽  
Author(s):  
Diana I. S. P. Resende ◽  
Patrícia Pereira-Terra ◽  
Joana Moreira ◽  
Joana Freitas-Silva ◽  
Agostinho Lemos ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Biofilm Formation ◽  
Multidrug Resistant ◽  
Inhibitory Effect ◽  
X Ray Diffraction ◽  
X Ray ◽  
Xanthone Derivatives ◽  
Potent Inhibitory Effect ◽  
Resistant Strains

A series of thirteen xanthones 3–15 was prepared based on substitutional (appendage) diversity reactions. The series was structurally characterized based on their spectral data and HRMS, and the structures of xanthone derivatives 1, 7, and 8 were determined by single-crystal X-ray diffraction. This series, along with an in-house series of aminated xanthones 16–33, was tested for in-vitro antimicrobial activity against seven bacterial (including two multidrug-resistant) strains and five fungal strains. 1-(Dibromomethyl)-3,4-dimethoxy-9H-xanthen-9-one (7) and 1-(dibromomethyl)-3,4,6-trimethoxy-9H-xanthen-9-one (8) exhibited antibacterial activity against all tested strains. In addition, 3,4-dihydroxy-1-methyl-9H-xanthen-9-one (3) revealed a potent inhibitory effect on the growth of dermatophyte clinical strains (T. rubrum FF5, M. canis FF1 and E. floccosum FF9), with a MIC of 16 µg/mL for all the tested strains. Compounds 3 and 26 showed a potent inhibitory effect on two C. albicans virulence factors: germ tube and biofilm formation.

scholarly journals X-ray Crystal Structure, Geometric Isomerism, and Antimicrobial Activity of New Copper(II) Carboxylate Complexes with Imidazole Derivatives

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3253 ◽  
Author(s):  
Ioana Vlaicu ◽  
Gheorghe Borodi ◽  
Gina Scăețeanu ◽  
Mariana Chifiriuc ◽  
Luminița Măruțescu ◽  
...  
Keyword(s):  
Antimicrobial Activity ◽  
Single Crystal ◽  
Antimicrobial Agents ◽  
Biological Evaluation ◽  
Infrared Spectrometry ◽  
X Ray Diffraction ◽  
X Ray ◽  
Imidazole Derivatives ◽  
Potential Applications

Five new copper(II) acrylate complexes (acr is the acrylate anion: C3H3O2) with imidazole derivatives (2-methylimidazole/2-MeIm, 5-methylimidazole/5-MeIm, 2-ethylimidazole/2-EtIm) of type: cis-[Cu(2-RIm)2(acr)2]·xH2O ((1): R = –CH3, x = 2; (4): R = –CH2–CH3, x = 0), trans-[Cu(2-RIm)2(acr)2] ((2): R = –CH3; (5): R = –CH2–CH3) and trans-[Cu(5-RIm)2(acr)2] ((3): R = –CH3) have been prepared and characterized by elemental analysis, Fourier Transform Infrared spectrometry (FTIR), Electron Paramagnetic Resonance (EPR), electronic reflectance spectroscopy, scanning electron microscopy, and mass spectrometry. The single crystal X-ray diffraction study of complexes (2) and (5) reveals that the copper(II) ion is located on an inversion center and show elongated octahedral geometry completed by two coplanar bidentate acrylates and two unidentate imidazole derivatives displayed in trans positions. For complex (4) the single crystal X-ray diffraction shows that the copper(II) ion is in a distorted octahedral environment which can be easily confused with a trigonal prism completed by two bidentate acrylates and two unidentate imidazole derivatives displayed in cis positions. These results indicate the fact that complexes (4) and (5) are the geometric isomers of the same compound bis(acrylate)-bis(2-ethylimidazole)-copper(II). Complexes (1) and (2), as well as (4) and (5), were produced simultaneously in the reaction of the corresponding copper(II) acrylate with imidazole derivatives in methanol solution. Furthermore, in order to be able to formulate potential applications of the obtained compounds, our next goal was to investigate the in vitro antimicrobial activity of the synthesized complexes against Gram-positive and Gram-negative bacteria, as well as fungal strains, of both clinical and ecological importance (biodeterioration of historical buildings). The trans isomers (2) and (5), followed by (4) have shown the broadest range of antimicrobial activity. In case of (1) and (2) isomers, the trans isomer (2) was significantly more active than cis (1), while the cis isomer (4) proved to be more active than trans (5). Taken together, the biological evaluation results indicate that the trans (2) was the most active complex, demonstrating its potential for the development of novel antimicrobial agents, with potential applications in the biomedical and restoration of architectural monuments fields.

Synthesis, Crystal Structure, Spectral and Thermal Characterization, and Antimicrobial Activity of [Cu(HOr)(aepy)(H2O)] ·H2O (aepy = 2-aminoethylpyridine, HOr2– = orotate)

2007 ◽  
Vol 62 (12) ◽  
pp. 1590-1594 ◽  
Author(s):  
Okan Zafer Yeşilel ◽  
Necmi Dege ◽  
Cihan Darcan ◽  
Orhan Büyükgüngör
Keyword(s):  
Crystal Structure ◽  
Thermal Analysis ◽  
Antimicrobial Activity ◽  
Magnetic Susceptibility ◽  
Thermal Characterization ◽  
Coordination Geometry ◽  
Chelating Ligands ◽  
X Ray Diffraction ◽  
X Ray ◽  
Triclinic System

The copper(II) orotate complex with 2-aminoethylpyridine, [Cu(HOr)(aepy)(H2O)] ·H2O, was synthesized and characterized by means of elemental and thermal analysis, magnetic susceptibility, IR and UV/vis spectroscopic, single crystal X-ray diffraction, and antimicrobial activity studies. The complex crystallizes in the triclinic system, space group P1̅, and the Cu(II) ion is five-coordinate with a distorted square-pyramidal coordination geometry. The aepy ligand and the orotate dianion behave as bidentate (N,N′ and N,Oacid) chelating ligands. The crystal structure is stabilized by intermolecular O-H···O and N-H···O hydrogen bonds, and the orotate ligand exhibits a double hydrogenbonding functionality. The new compound was found active against some gram (+)/(−) bacteria and yeast Candida albicans ATCC 10231, but there was no activity on Aspergillus niger.

scholarly journals Copper(II) Complexes of 2-(Methylthiomethyl)anilines: Spectral and Structural Properties and In Vitro Antimicrobial Activity

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Temitope E. Olalekan ◽  
Denzil R. Beukes ◽  
Bernardus Van Brecht ◽  
Gareth M. Watkins
Keyword(s):  
Antimicrobial Activity ◽  
Electronic Spectra ◽  
Copper Complexes ◽  
Structural Formula ◽  
Bidentate Ligand ◽  
X Ray Diffraction ◽  
X Ray ◽  
X Ray Crystallography ◽  
Elemental Analyses

Copper(II) complexes of 2-(methylthiomethyl)anilines (1a–1f) have been obtained and characterized by elemental analyses, IR, electronic spectra, conductivity, and X-ray crystallography. The complexes (2a–2f) have the structural formula [CuCl2L] with the bidentate ligand coordinating through sulfur and nitrogen. The single crystal X-ray diffraction data reveal that the copper complex (2f) has a tetragonally distorted octahedral structure with long Cu–Cl equatorial bonds. Magnetic susceptibility measurements indicate the availability of one unpaired electron in the complexes and the conductivity measurements in DMF show their behaviour as nonelectrolytes. The solid reflectance spectra and the electronic spectra of the complexes in DMSO were determined. The ligands and their copper complexes were screened for in vitro antimicrobial activity against S. aureus, B. subtilis, E. coli, and C. albicans. The methoxysubstituted complex (2c) showed more promising antibacterial activity against S. aureus and B. subtilis than other compounds at the concentration tested.

A study on using expanded perlite with hydroxyapatite: Reinforced bio-composites

2021 ◽  
pp. 095441192199656
Author(s):  
Erdoğan Karip ◽  
Mehtap Muratoğlu
Keyword(s):  
Body Fluid ◽  
Xrd Analysis ◽  
Cold Isostatic Pressing ◽  
Expanded Perlite ◽  
X Ray Diffraction ◽  
Pressing Method ◽  
X Ray ◽  
Infra Red ◽  
Ft Ir

People are exposed to different kinds of diseases or various accidents in life. Hydroxyapatite (HA) has been widely employed for bone treatment applications. In this study, HA was extracted from sheep bones. Bio-composites were doped with 1, 5, and 10 wt.% of expanded perlite and 5 wt.% of ZrO2–MgO-P2O5. The bio-composites were prepared by the cold isostatic pressing method (250 MPa) and sintered at 900°C for 1 h. In order to evaluate the characteristics of the bio-composites, microhardness, density, X-ray diffraction (XRD), Fourier transform infra-red spectroscopy (FT-IR), scanning electron microscopy (SEM), and energy dispersive spectroscopy (EDS) analyses were carried out on them. Additionally, the specimens whose characteristics were determined were kept in synthetic body fluid (SBF), and their in vitro behavior was examined. As a result, it was observed that microhardness increased as both the weight and the grain size of the expanded perlite were increased. Calcium silicate, tri-calcium phosphate, and hydroxyapatite were observed in the XRD analysis of all samples, and the formation of apatite structures was increased by addition of ZrO2–MgO–P2O5.

Fabrication and evaluation of calcium phosphate cement scaffold with controlled internal channel architecture and complex shape

2007 ◽  
Vol 221 (8) ◽  
pp. 951-958 ◽  
Author(s):  
X Li ◽  
D Li ◽  
B Lu ◽  
L Wang ◽  
Z Wang
Keyword(s):  
Tissue Engineering ◽  
Calcium Phosphate ◽  
Calcium Phosphate Cement ◽  
Complex Shape ◽  
X Ray Diffraction ◽  
X Ray ◽  
Precise Control ◽  
Internal Channel ◽  
Channel Architecture

The ability to have precise control over internal channel architecture, porosity, and external shape is essential for tissue engineering. The feasibility of using indirect stereo-lithography (SL) to produce scaffolds from calcium phosphate cement materials for bone tissue engineering has been investigated. The internal channel architecture of the scaffolds was created by removal of the negative resin moulds made with SL. Scanning electron microscopy (SEM) showed highly open, well-interconnected channel architecture. The X-ray diffraction examination revealed that the hydroxyapatite phase formed at room temperature in the cement was basically stable up to 850 °C. There was no phase decomposition of hydroxyapatite, although the crystallinity and grain size were different. The ability of resulting structure to support osteoblastic cells culture was tested in vitro. Cells were evenly distributed on exterior surfaces and grew into the internal channels of scaffolds. To exploit the ability of this technique, anatomically shaped femoral supracondylar scaffolds with 300-800 μm interconnected channels were produced and characterized.

A Novel Missense Mutation (p.P52R) in Amelogenin Gene Causing X-linked Amelogenesis Imperfecta

2007 ◽  
Vol 86 (1) ◽  
pp. 69-72 ◽  
Author(s):  
M. Kida ◽  
Y. Sakiyama ◽  
A. Matsuda ◽  
S. Takabayashi ◽  
H. Ochi ◽  
...  
Keyword(s):  
Novel Mutation ◽  
Dental Enamel ◽  
Fluorescence Analysis ◽  
Hereditary Disease ◽  
Amelogenesis Imperfecta ◽  
X Ray Diffraction ◽  
Japanese Family ◽  
X Ray ◽  
Amelogenin Gene

Amelogenesis imperfecta (AI) is a hereditary disease with abnormal dental enamel formation. Here we report a Japanese family with X-linked AI transmitted over at least four generations. Mutation analysis revealed a novel mutation (p.P52R) in exon 5 of the amelogenin gene. The mutation was detected as heterozygous in affected females and as hemizygous in their affected father. The affected sisters exhibited vertical ridges on the enamel surfaces, whereas the affected father had thin, smooth, yellowish enamel with distinct widening of inter-dental spaces. To study the pathological cause underlying the disease in this family, we synthesized the mutant amelogenin p.P52R protein and evaluated it in vitro. Furthermore, we studied differences in the chemical composition between normal and affected teeth by x-ray diffraction analysis and x-ray fluorescence analysis. We believe that these results will greatly aid our understanding of the pathogenesis of X-linked AI.

THE STUDY ON GRANTING BIOACTIVITY OF Ti ALLOY BY SURFACE TREATMENT

2010 ◽  
Vol 17 (02) ◽  
pp. 153-157 ◽  
Author(s):  
N. R. HA ◽  
Z. X. YANG ◽  
G. C. KIM ◽  
K. H. HWANG ◽  
D. S. SEO ◽  
...  
Keyword(s):  
Surface Treatment ◽  
Body Fluid ◽  
Surface Effect ◽  
In Vitro Test ◽  
Ti Alloy ◽  
X Ray Diffraction ◽  
X Ray ◽  
Chemical Surface ◽  
Vitro Test

Titanium alloys are superior of biocompatibility, mechanical properties and chemical stability. The biocompatibility of Ti alloy is related to the surface effect between human tissue and implant. Therefore, the purpose of this study is to investigate the bioactivity of Ti alloy by alkali and acid chemical surface treatment; and the biocompatibility of Ti alloy was evaluated by in vitro test. Higher bone-bonding ability and bioactivity of the substrate were obtained by the formation of apatite layers on the Ti alloy in simulated body fluid. The microstructures of apatite layer were investigated by scanning electron microscope (SEM) and the formed phases were analyzed with X-ray diffraction (XRD).

Mesenchymal Stem Cell Response to Surface Altered Porous Ti

2015 ◽  
Vol 638 ◽  
pp. 67-72
Author(s):  
Ana Maria Salantiu ◽  
Florin Popa ◽  
Petru Pascuta ◽  
Olga Soritau ◽  
Noemi Dirzu ◽  
...  
Keyword(s):  
Stem Cell ◽  
X Ray Diffraction ◽  
X Ray ◽  
Chemically Modified ◽  
Porous Ti ◽  
Average Porosity ◽  
Ft Ir ◽  
Cell Testing ◽  
Scanning Electron

This work aims to investigate the influence of surface conditioning of porous Ti for enhancing its biological activity, as assessed by in vitro stem cell testing. Porous Ti samples with an average porosity of 32% were processed by Powder Metallurgy with dextrin as a space holder. The samples were subjected to H2O2 treatment to form an enhanced TiO2 film, followed by a heat treatment at 400°C and 600°C aiming to the crystallization of the as-formed amorphous titanium oxide. Samples characterization was performed by Scanning Electron Microscopy (SEM), Fourier Transform Infrared Spectroscopy (FT-IR) and X-Ray Diffraction (XRD). The treated surfaces revealed to be made of both anatase and rutile TiO2, with groove–shaped structure and cracks on the surface of the TiO2 film. The intrinsic biocompatibility of the chemically modified porous Ti surfaces was assessed in vitro. In our cell culture tests, stem cells were found to attach and proliferate better on the chemically treated Ti surfaces compared to the control untreated Ti surfaces.

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