scholarly journals Chemical Constituents of the Leaves of Peltophorum pterocarpum and Their Bioactivity

Molecules ◽  
2019 ◽  
Vol 24 (2) ◽  
pp. 240 ◽  
Author(s):  
Yue-Chiun Li ◽  
Ping-Chung Kuo ◽  
Mei-Lin Yang ◽  
Tzu-Yu Chen ◽  
Tsong-Long Hwang ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Mass Spectrometric ◽  
Inhibitory Effects ◽  
Superoxide Anion Generation ◽  
Chemical Structures

Two new sesquiterpenoids peltopterins A and B (compounds 1 and 2) and fifty-two known compounds were isolated from the methanol extract of P. pterocarpum and their chemical structures were established through spectroscopic and mass spectrometric analyses. The isolates 40, 43, 44, 47, 48, 51 and 52 exhibited potential inhibitory effects of superoxide anion generation or elastase release.

scholarly journals Chemical Constituents of Vigna luteola and Their Anti-inflammatory Bioactivity

Molecules ◽  
2019 ◽  
Vol 24 (7) ◽  
pp. 1371 ◽  
Author(s):  
Sio-Hong Lam ◽  
Yue-Chiun Li ◽  
Ping-Chung Kuo ◽  
Tsong-Long Hwang ◽  
Mei-Lin Yang ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Methanol Extract ◽  
Chemical Constituents ◽  
Mass Spectrometric ◽  
Inhibitory Effects ◽  
Potential Evaluation ◽  
Anti Inflammatory ◽  
Vigna Luteola

Seventy-three compounds were identified from the methanol extract of V. luteola, and among these, three new (1–3) were characterized by spectroscopic and mass spectrometric analyses. The isolated constituents were assessed for anti-inflammatory potential evaluation, and several purified principles exhibited significant superoxide anion and elastase inhibitory effects.

scholarly journals Anti-Inflammatory Cembranoids from a Formosa Soft Coral Sarcophyton cherbonnieri

Marine Drugs ◽  
2020 ◽  
Vol 18 (11) ◽  
pp. 573
Author(s):  
Chia-Chi Peng ◽  
Chiung-Yao Huang ◽  
Atallah F. Ahmed ◽  
Tsong-Long Hwang ◽  
Jyh-Horng Sheu
Keyword(s):  
Superoxide Anion ◽  
Soft Coral ◽  
Chemical Reduction ◽  
Chemical Constituents ◽  
2D Nmr ◽  
Human Neutrophils ◽  
Superoxide Anion Generation ◽  
Chemical Structures ◽  
Proinflammatory Responses ◽  
Anti Inflammatory

The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F–L (1–7). The chemical structures of 1–7 were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of 1–7 against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (2) and cherbonolide H (3) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively.

Inhibitory effects of cardols and related compounds on superoxide anion generation by xanthine oxidase

2015 ◽  
Vol 166 ◽  
pp. 270-274 ◽  
Author(s):  
Noriyoshi Masuoka ◽  
Ken-ichi Nihei ◽  
Ayami Maeta ◽  
Yoshiro Yamagiwa ◽  
Isao Kubo
Keyword(s):  
Xanthine Oxidase ◽  
Superoxide Anion ◽  
Inhibitory Effects ◽  
Superoxide Anion Generation ◽  
Related Compounds

Inhibitory Effects of N-acetylcysteine on Superoxide Anion Generation in Human Polymorphonuclear Leukocytes

1997 ◽  
Vol 49 (5) ◽  
pp. 525-529 ◽  
Author(s):  
VICTORIA VILLAGRASA ◽  
JULIO CORTIJO ◽  
MIGUEL MARTÍ-CABRERA ◽  
JOSÉ L. ORTIZ ◽  
LUISA BERTO ◽  
...  
Keyword(s):  
Superoxide Anion ◽  
Polymorphonuclear Leukocytes ◽  
Inhibitory Effects ◽  
Superoxide Anion Generation ◽  
Human Polymorphonuclear Leukocytes

scholarly journals Iridoid Glycosides and Phenolic Glycosides from Buddleja asiatica with Anti-inflammatory and Cytoprotective Activities

2018 ◽  
Vol 13 (1) ◽  
pp. 1934578X1801300 ◽  
Author(s):  
Truong Thi Thu Hien ◽  
Tran Hong Quang ◽  
Bui Huu Tai ◽  
Nguyen Xuan Nhiem ◽  
Pham Hai Yen ◽  
...  
Keyword(s):  
Cell Death ◽  
Methanol Extract ◽  
Iridoid Glycosides ◽  
Iridoid Glycoside ◽  
Inhibitory Effects ◽  
Chemical Structures ◽  
Aerial Parts ◽  
Spectroscopic Analyses ◽  
Nitrite Production ◽  
Bv2 Microglia

Chemical investigation of the methanol extract of the aerial parts of Buddleja asiatica resulted in the isolation of a new iridoid glycoside, buddlejasiaside A (1) and 11 known compounds: 6- O -[α-L-(4-isoferuloyl)-rhamnopyranosylcatalpol (2), specioside (3), verminoside (4), minecoside (5), 6- O -( p -hydroxybenzoyl)-ajugol (6), 6- O -caffeoyl ajugol (7), litanthosalin 8), eurostoside (9), 10- O -caffeoylaucubin (10), phlorizin (11), and garashangin (12). Their chemical structures were identified based on the MS and NMR spectroscopic analyses and comparing with the data reported in the literature. Compounds 1, 2, and 8-10 showed the modest inhibitory effects against nitrite production in LPS-stimulated BV2 microglia, with IC50 values ranging from 43.5-79.6 μM. Compounds 6, 7, and 11 protected HT22 hippocampal cells from glutamate-induced cell death, with EC50 values of 38.9, 14.8, and 27.1 μM, respectively.

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