Chemical Constituents of Vigna luteola and Their Anti-inflammatory Bioactivity

Seventy-three compounds were identified from the methanol extract of V. luteola, and among these, three new (1–3) were characterized by spectroscopic and mass spectrometric analyses. The isolated constituents were assessed for anti-inflammatory potential evaluation, and several purified principles exhibited significant superoxide anion and elastase inhibitory effects.

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Chemical Constituents of the Leaves of Peltophorum pterocarpum and Their Bioactivity

Molecules ◽

10.3390/molecules24020240 ◽

2019 ◽

Vol 24 (2) ◽

pp. 240 ◽

Cited By ~ 5

Author(s):

Yue-Chiun Li ◽

Ping-Chung Kuo ◽

Mei-Lin Yang ◽

Tzu-Yu Chen ◽

Tsong-Long Hwang ◽

...

Keyword(s):

Superoxide Anion ◽

Methanol Extract ◽

Chemical Constituents ◽

Mass Spectrometric ◽

Inhibitory Effects ◽

Superoxide Anion Generation ◽

Chemical Structures

Two new sesquiterpenoids peltopterins A and B (compounds 1 and 2) and fifty-two known compounds were isolated from the methanol extract of P. pterocarpum and their chemical structures were established through spectroscopic and mass spectrometric analyses. The isolates 40, 43, 44, 47, 48, 51 and 52 exhibited potential inhibitory effects of superoxide anion generation or elastase release.

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Chemical Constituents from Scindapsus officinalis (Roxb.) Schott. and Their Anti–Inflammatory Activities

Molecules ◽

10.3390/molecules23102577 ◽

2018 ◽

Vol 23 (10) ◽

pp. 2577 ◽

Cited By ~ 2

Author(s):

Hongjing Dong ◽

Yanling Geng ◽

Xueyong Wang ◽

Xiangyun Song ◽

Xiao Wang ◽

...

Keyword(s):

Chemical Constituents ◽

2D Nmr ◽

No Production ◽

Inhibitory Effects ◽

Nmr Data ◽

Extensive Analysis ◽

Ic50 Values ◽

Monoterpene Glycoside ◽

Anti Inflammatory

One new monoterpene glycoside (1), one new phenyl glycoside (2), one new caffeoyl derivative (3), were isolated from Scindapsus officinalis (Roxb.) Schott., along with four known compounds (4–7). Structures of the isolated compounds were elucidated by extensive analysis of spectroscopic data, especially 2D NMR data and comparison with literatures. All isolates were evaluated for anti-inflammatory activity against nitric oxide (NO) production in vitro. Compounds 3 and 7 exhibited moderate inhibitory effects on NO production with IC50 values of 12.2 ± 0.8 and 18.9 ± 0.3 μM, respectively.

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Comparison of Anti-inflammatory Activities of Six Curcuma Rhizomes: A Possible Curcuminoid-independent Pathway Mediated by Curcuma phaeocaulis Extract

Evidence-based Complementary and Alternative Medicine ◽

10.1093/ecam/nel008 ◽

2006 ◽

Vol 3 (2) ◽

pp. 255-260 ◽

Cited By ~ 82

Author(s):

Chihiro Tohda ◽

Natsuki Nakayama ◽

Fumiyuki Hatanaka ◽

Katsuko Komatsu

Keyword(s):

Adjuvant Arthritis ◽

Acute Inflammation ◽

Methanol Extract ◽

Curcuma Longa ◽

Curcuma Zedoaria ◽

Inhibitory Effects ◽

Serum Haptoglobin ◽

Haptoglobin Concentration ◽

Anti Inflammatory ◽

Curcuma Kwangsiensis

We aimed to compare the anti-inflammatory activities of six species ofCurcumadrugs using adjuvant arthritis model mice. When orally administered 1 day before the injection of adjuvant, the methanol extract ofCurcuma phaeocaulissignificantly inhibited paw swelling and the serum haptoglobin concentration in adjuvant arthritis mice. Also when orally administered 1 day after the injection of adjuvant, the methanol extract ofCurcuma phaeocaulissignificantly inhibited paw swelling. OtherCurcumaspecies (Curcuma longa, Curcuma wenyujin, Curcuma kwangsiensis, Curcuma zedoariaandCurcuma aromatica) had no significant inhibitory effects on adjuvant-induced paw swelling. Cyclooxygenase (COX)-2 activity was significantly inhibited by the methanol extract ofC. phaeocaulis. Curcuminoids' (curcumin, bis-demethoxycurcumin and demethoxycurcumin) were rich inC. longa, but less inC. phaeocaulisandC. aromatica, not inC. wenyujin, C. kwangsiensisandC. zedoaria, suggesting that curcuminoids' contents do not relate to inhibition of arthritis swelling. Therefore,C. phaeocaulismay be a useful drug amongCurcumaspecies for acute inflammation, and the active constituents ofC. phaeocaulisare not curcuminoids.

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Chemical Constituents from the Roots of Polygala arillata and Their Anti-Inflammatory Activities

Journal of Chemistry ◽

10.1155/2019/8079619 ◽

2019 ◽

Vol 2019 ◽

pp. 1-8 ◽

Cited By ~ 2

Author(s):

Wei Xiang ◽

Guo-Dong Zhang ◽

Fang-Yi Li ◽

Teng-long Wang ◽

Tong-Chuan Suo ◽

...

Keyword(s):

Oleanolic Acid ◽

Chemical Constituents ◽

Sinapic Acid ◽

Ethanolic Extract ◽

Raw 264.7 Cells ◽

No Production ◽

Raw 264.7 ◽

Activated Macrophages ◽

Inhibitory Effects ◽

Anti Inflammatory

A new compound, named arillatanoside E, which was elucidated as 3-O-β-D-glucopyranosyl presenegenin 28-O-β-D-xylopyranosyl-(1 ⟶ 3)-β-D-xylopyranosyl-(1 ⟶ 4)-α-L-rhamnopyranosyl-(1 ⟶ 2)-(4-O-acetyl)-β-D-fucopyranosyl ester, along with 11 known compounds was isolated from the ethanolic extract of the roots of Polygala arillata. The 11 known compounds were identified as oleanolic acid (2), 3′-E-3,4,5-trimethoxy cinnamoyl-6-benzoyl sucrose (3), trans-ferulic acid (4), trans-feruloyl-glucoside (5), feruloyl-glucoside (6), 2,4,6-trimethoxy-1-O-β-D-glycoside (7), 3-methoxy-4-hydroxybenzoic acid (8), monopentadecanoin (9), sinapic acid (10), p-hydroxybenzaldehyde (11), and palmitic acid (12). Among them, seven isolated compounds 1, 2, 4, 5, 7, 8, and 10 exhibited little cytotoxic activity on macrophage RAW 264.7 cells. Then, the inhibitory effects of 7 isolates on nitric oxide (NO) production in lipopolysaccharide-activated macrophages were evaluated. As a result, 3 compounds have significant anti-inflammatory activity, and they were arillatanoside E (1), oleanolic acid (2), and 2,4,6-trimethoxy-1-O-β-D-glycoside (7).

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Anti-Inflammatory Cembranoids from a Formosa Soft Coral Sarcophyton cherbonnieri

Marine Drugs ◽

10.3390/md18110573 ◽

2020 ◽

Vol 18 (11) ◽

pp. 573

Author(s):

Chia-Chi Peng ◽

Chiung-Yao Huang ◽

Atallah F. Ahmed ◽

Tsong-Long Hwang ◽

Jyh-Horng Sheu

Keyword(s):

Superoxide Anion ◽

Soft Coral ◽

Chemical Reduction ◽

Chemical Constituents ◽

2D Nmr ◽

Human Neutrophils ◽

Superoxide Anion Generation ◽

Chemical Structures ◽

Proinflammatory Responses ◽

Anti Inflammatory

The present investigation on chemical constituents of the soft coral Sarcophyton cherbonnieri resulted in the isolation of seven new cembranoids, cherbonolides F–L (1–7). The chemical structures of 1–7 were determined by spectroscopic methods, including infrared, one- and two-dimensional (1D and 2D) NMR (COSY, HSQC, HMBC, and NOESY), MS experiments, and a chemical reduction of hydroperoxide by triphenylphosphine. The anti-inflammatory activities of 1–7 against neutrophil proinflammatory responses were evaluated by measuring their inhibitory ability toward N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLF/CB)-induced superoxide anion generation and elastase release in primary human neutrophils. The results showed that all isolates exhibited moderate activities, while cherbonolide G (2) and cherbonolide H (3) displayed a more active effect than others on the inhibition of elastase release (48.2% ± 6.2%) and superoxide anion generation (44.5% ± 4.6%) at 30 µM, respectively.

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Chemical Constituents from the Stems of Tinospora sinensis and Their Bioactivity

Molecules ◽

10.3390/molecules23102541 ◽

2018 ◽

Vol 23 (10) ◽

pp. 2541 ◽

Cited By ~ 8

Author(s):

Sio-Hong Lam ◽

Po-Hsun Chen ◽

Hsin-Yi Hung ◽

Tsong-Long Hwang ◽

Chih-Chao Chiang ◽

...

Keyword(s):

Analytical Methods ◽

Superoxide Anion ◽

Cytochalasin B ◽

Chemical Constituents ◽

Superoxide Anion Generation ◽

Anti Inflammatory ◽

New Compounds

Fifty-seven compounds were purified from the stems of Tinospora sinensis, including three new compounds characterized as a lignan (1), a pyrrole alkaloid (11), and a benzenoid (17), respectively. Their structures were elucidated and established by various spectroscopic and spectrometric analytical methods. Among the isolates, fifteen compounds were examined for their anti-inflammatory potential in vitro. The results showed that several compounds displayed moderate inhibition of N-formyl-methionyl-leucyl-phenylalanine/cytochalasin B (fMLP/CB)-induced superoxide anion generation and elastase release.

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