scholarly journals Bioactive Dimeric Abietanoid Peroxides from the Bark of Cryptomeria japonica

Molecules ◽  
2019 ◽  
Vol 24 (11) ◽  
pp. 2178 ◽  
Author(s):  
Chi-I Chang ◽  
Cheng-Chi Chen ◽  
Chiy-Rong Chen ◽  
Ming-Der Wu ◽  
Ming-Jen Cheng ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Xanthine Oxidase ◽  
Cryptomeria Japonica ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Converting Enzyme ◽  
Addition Compound ◽  
Nmr Data ◽  
Oxidase Enzyme

Three new dimeric abietane-type diterpenoids, abieta-6,8,11,13-tetraen-12-yl 12-hydroxyabieta-8,11,13-trien-7α-yl peroxide (1), abieta-6,8,11,13-tetraen-12-yl 12-hydroxyabieta-8,11,13-trien-7β-yl peroxide (2), and 12-hydroxyabieta-8,11,13-trien-7β-yl 7-oxoabieta-5,8,11,13-tetraen-12-yl peroxide (3), together with four known abietane-type diterpenoids (4–7) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. At a concentration of 50 μM, compounds 1, 2, and 3 showed 26.2%, 23.6%, and 35.7% inhibition towards xanthine oxidase enzyme, respectively. In addition, compound 3 also showed 24.9% inhibition toward angiotensin-converting enzyme (ACE).

scholarly journals New Abietane-type Diterpenoids from the Bark of Cryptomeria japonica

2019 ◽  
Vol 14 (1) ◽  
pp. 1934578X1901400
Author(s):  
Chi-I Chang ◽  
Jih-Jung Cheng ◽  
Chin Hsu ◽  
Cheng-Chi Chen ◽  
Wei-Yi Cheng ◽  
...  
Keyword(s):  
Xanthine Oxidase ◽  
Cryptomeria Japonica ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Nmr Data ◽  
Oxidase Enzyme

Two new abietane-type diterpenoids, 15-hydroxy-12- O-methylsugiol (1) and 2a-hydroxy-12- O-methylsugiol (2) were isolated from the methanol extract of the bark of Cryptomeria japonica. Their structures were elucidated on the basis of spectroscopic analysis and comparison of NMR data with those of known analogues. Compounds 2 showed 13.5% inhibition towards xanthine oxidase enzyme at the concentration of 75 μM

scholarly journals Novel Antifungal Dimers from the Roots of Taiwania cryptomerioides

Molecules ◽  
2022 ◽  
Vol 27 (2) ◽  
pp. 437
Author(s):  
Ming-Jen Cheng ◽  
Ming-Der Wu ◽  
Chao-Lin Chang ◽  
Hsun-Shuo Chang ◽  
Chiou-Fung Chyu ◽  
...  
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Candida Albicans ◽  
Aspergillus Niger ◽  
Spectroscopic Analysis ◽  
Methanol Extract ◽  
Penicillium Italicum ◽  
Antifungal Activities ◽  
Nmr Data ◽  
Taiwania Cryptomerioides

Five new dimer compounds, namely Taiwaniacryptodimers A‒E (1–5), were isolated from the methanol extract of the roots of Taiwania cryptomerioides. Their structures were established by mean of spectroscopic analysis and comparison of NMR data with those of known analogues. Their antifungal activities were also evaluated. Our results indicated that metabolites 1, 2, 4, and 5 displayed moderate antifungal activities against Aspergillus niger, Penicillium italicum, Candida albicans, and Saccharomyces cerevisiae.

scholarly journals Optimization of an Extraction Solvent for Angiotensin-Converting Enzyme Inhibitors from Hibiscus sabdariffa L. Based on Its UPLC-MS/MS Metabolic Profiling

Molecules ◽  
2020 ◽  
Vol 25 (10) ◽  
pp. 2307 ◽  
Author(s):  
Mohamed A. Salem ◽  
Haidy E. Michel ◽  
Marwa I. Ezzat ◽  
Mona M. Okba ◽  
Ahmed M. EL-Desoky ◽  
...  
Keyword(s):  
Angiotensin Converting Enzyme ◽  
Organic Acids ◽  
Methanol Extract ◽  
Enzyme Inhibitors ◽  
Angiotensin Converting Enzyme Inhibitors ◽  
Ultra Performance Liquid Chromatography ◽  
Hibiscus Sabdariffa ◽  
Converting Enzyme ◽  
Converting Enzyme Inhibitors ◽  
Folk Remedy

Hibiscus species (Malvaceae) have been long used as an antihypertensive folk remedy. The aim of our study was to specify the optimum solvent for extraction of the angiotensin-converting enzyme inhibiting (ACEI) constituents from Hibiscus sabdariffa L. The 80% methanol extract (H2) showed the highest ACEI activity, which exceeds that of the standard captopril (IC50 0.01255 ± 0.00343 and 0.210 ± 0.005 µg/mL, respectively). Additionally, in a comprehensive metabolomics approach, an ultra-performance liquid chromatography (UPLC) coupled to the high resolution tandem mass spectrometry (HRMS) method was used to trace the metabolites from each extraction method. Interestingly, our comprehensive analysis showed that the 80% methanol extract was predominated with secondary metabolites from all classes including flavonoids, anthocyanins, phenolic and organic acids. Among the detected metabolites, phenolic acids such as ferulic and chlorogenic acids, organic acids such as citrate derivatives and flavonoids such as kaempferol have been positively correlated to the antihypertensive potential. These results indicates that these compounds may significantly contribute synergistically to the ACE inhibitory activity of the 80% methanol extract.

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