scholarly journals Bioactivity and Bioavailability of the Major Metabolites of Crocus sativus L. Flower

Molecules ◽  
2019 ◽  
Vol 24 (15) ◽  
pp. 2827 ◽  
Author(s):  
Moratalla-López ◽  
Bagur ◽  
Lorenzo ◽  
Salinas ◽  
Alonso
Keyword(s):  
Antioxidant Capacity ◽  
Critical Review ◽  
Analytical Methods ◽  
Mechanisms Of Action ◽  
Crocus Sativus ◽  
Crocus Sativus L ◽  
Identification And Quantification

Crocus sativus L. has been cultivated throughout history to obtain its flowers, whose dried stigmas give rise to the spice known as saffron. Crocetin esters, picrocrocin, and safranal are the main metabolites of this spice, which possess a great bioactivity, although the mechanisms of action and its bioavailability are still to be solved. The rest of the flower is composed by style, tepals, and stamens that have other compounds, such as kaempferol and delphinidin, which have an important antioxidant capacity, and these can be applied in foods, phytopharmaceuticals, and cosmetics. The aim of this work was to provide an updated and critical review of the research on the main compounds of Crocus sativus L. flower, including the adequate analytical methods for their identification and quantification, with a focus on their bioactivity and bioavailability.

Sudan dyes in adulterated saffron (Crocus sativus L.): Identification and quantification by 1H NMR

2017 ◽  
Vol 217 ◽  
pp. 418-424 ◽  
Author(s):  
Eleftherios A. Petrakis ◽  
Laura R. Cagliani ◽  
Petros A. Tarantilis ◽  
Moschos G. Polissiou ◽  
Roberto Consonni
Keyword(s):  
1H Nmr ◽  
Crocus Sativus ◽  
Sudan Dyes ◽  
Crocus Sativus L ◽  
Identification And Quantification

scholarly journals Development of New Extracts of Crocus sativus L. By-Product from Two Different Italian Regions as New Potential Active Ingredient in Cosmetic Formulations

Cosmetics ◽  
2021 ◽  
Vol 8 (2) ◽  
pp. 51
Author(s):  
Maria Rosa Gigliobianco ◽  
Manuela Cortese ◽  
Dolores Vargas Peregrina ◽  
Carla Villa ◽  
Giulio Lupidi ◽  
...  
Keyword(s):  
Antioxidant Capacity ◽  
Skin Irritation ◽  
Sodium Dodecyl ◽  
Water Extract ◽  
Crocus Sativus ◽  
Green Solvents ◽  
Biological Potential ◽  
Italian Regions ◽  
First Time ◽  
Crocus Sativus L

This project aimed to apply eco-friendly extraction methods to Crocus sativus L. by-product (flowers without stigmas i.e., tepals composed of petals and sepals) to recover extracts with high antioxidant capacity and polyphenol content, to be used in cosmetic products. Flowers grown in two different Italian regions (Sample 1—Alba in Piemonte, north of Italy and Sample 2—Sibillini in Marche, centre of Italy) were subjected for the first time to different eco-friendly microwave-mediated green solvents extractions (MGSE) andquali-quantitative determination in antioxidant molecules. Firstly, the extracts from Sample 1 were selected according to their total phenol content (TPC) by Folin–Ciocalteu’s assay and antioxidant capacity (AC) by spectrophotometric assays. Then, according to preliminary results, MGSE carried out in ethanol 70°, water, and glycerin were selected as the most performing methods and applied to both Samples 1 and 2. The best results were obtained using green solvents, such as water or ethanol 70°, for the samples coming from Marche. The identification and quantification of phenolic compounds, belonging to anthocyanins and flavonols classes, was performed by using UPLC-DAD-ESI-MS. Concerning flavonols content, the most abundant analyte is kaempferol 3-O-sophoroside and the extract in water from Sample 1 showed the higher amount of flavonols, reaching the concentration of 25.35 mg of kaempferol 3-O-glucoside equivalent per gram of tepals DW of raw material. Among anthocyanins, the most abundant was delphinidin 3,5-O-diglucoside and the high concentration of anthocyanin was detected in water and ethanol extract. Two new compounds, myricetin-di-glucoside and primflasine, were identified for the first time in Crocus sativus L. by-product by high-resolution mass spectrometry (HRMS). The green batches obtained by extraction were thus characterized and evaluated for their biological potential and safety in keratinocyte HaCaT cells. The extracts were not cytotoxic up to 0.03 mg/mL. The water and ethanol 70° extracts were the most effective in counteracting oxidative stress induced by H2O2 and UVA exposure and reduced cytotoxicity induced by UVB exposure. The water extract was also able to significantly reduce cytotoxicity induced by sodium dodecyl sulphate-induced damage. Taken together, these results suggest a potential use of these waste materials as cosmeceutical preparations such as antiaging, and as anti-skin irritation formulation by-products.

Neuentwicklung einer HPLC-Methode zur Qualitätskontrolle von Safran (Crocus sativus L.)

2016 ◽  
Vol 37 (S 01) ◽  
Author(s):  
K Kuchta ◽  
HH Jin ◽  
RW Wang ◽  
HH He ◽  
L Fang ◽  
...  
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L

Biotechnological Studies in Saffron (Crocus sativus L.) Plant

2017 ◽  
Vol 7 (2) ◽  
pp. 343-352
Author(s):  
YONCA SURGUN ACAR ◽  
RABİA İŞKİL ◽  
BETÜL BÜRÜN
Keyword(s):  
Crocus Sativus ◽  
Crocus Sativus L

Anti-toxicant Properties of Saffron and Relevance to Protection from Toxins and Drugs

2020 ◽  
Vol 16 (3) ◽  
pp. 265-283
Author(s):  
Kyriaki Hatziagapiou ◽  
George I. Lambrou
Keyword(s):  
Redox Reactions ◽  
Case Reports ◽  
Meta Analysis ◽  
Reactive Oxygen ◽  
Crocus Sativus ◽  
Protective Effects ◽  
Nitrogen Species ◽  
Eligibility Criteria ◽  
Crocus Sativus L

Background: Reactive oxygen species and reactive nitrogen species, which are collectively called reactive oxygen nitrogen species, are inevitable by-products of cellular metabolic redox reactions, such as oxidative phosphorylation in the mitochondrial respiratory chain, phagocytosis, reactions of biotransformation of exogenous and endogenous substrata in endoplasmic reticulum, eicosanoid synthesis, and redox reactions in the presence of metal with variable valence. Among medicinal plants there is a growing interest in Crocus sativus L. It is a perennial, stemless herb, belonging to Iridaceae family, cultivated in various countries such as Greece, Italy, Spain, Israel, Morocco, Turkey, Iran, India, China, Egypt and Mexico. Objective: The present study aims to address the anti-toxicant role of Crocus sativus L. in the cases of toxin and drug toxification. Materials and Methods: An electronic literature search was conducted by the two authors from 1993 to August 2017. Original articles and systematic reviews (with or without meta-analysis), as well as case reports were selected. Titles and abstracts of papers were screened by a third reviewer to determine whether they met the eligibility criteria, and full texts of the selected articles were retrieved. Results: The authors focused on literature concerning the role of Crocus Sativus L. as an anti-toxicant agent. Literature review showed that Saffron is a potent anti-toxicant agent with a plethora of applications ranging from anti-oxidant properties, to chemotherapy protective effects. Conclusion: Literature findings represented in current review herald promising results for using Crocus Sativus L. and/or its active constituents as anti-toxicant, chemotherapy-induced protection and toxin protection.

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