Synthesis and antibacterial activity of some 1-(2-propynyl) and 1-propadienyl derivatives of 1,4-dihydro-4-oxoquinoline-3-carboxylic acids and similar heterocycles
1991 ◽
Vol 56
(2)
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pp. 439-448
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N-Alkylation of IIIa, IIIb, IIId - IIIf and 9-acridanone with 3-bromopropyne in dimethyl sulfoxide in the presence of potassium carbonate yielded N-(2-propynyl) derivatives IVa - IVe and VIa, respectively. Ethyl esters IVa, IVb, and IVe were hydrolyzed to IVf - IVh, respectively. Compounds IVf, IVg, IVctreated with bases yielded N-propadienyl derivatives Va - Vc. On the other hand 2-substituted compounds IVd and IVh did not change under the same conditions. Compound VIa treated with powdered potassium hydroxide in dimethyl sulfoxide at room temperature yielded N-(1-propynyl) derivative VII.
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2013 ◽
Vol 479-480
◽
pp. 855-860
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1979 ◽
Vol 34
(3)
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pp. 507-510
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Keyword(s):
2005 ◽
Vol 7
(3)
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pp. 121-124
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Keyword(s):
2021 ◽
Vol 4
◽
pp. 64-69
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