New Terpendole Congeners, Inhibitors of Sterol O-Acyltransferase, Produced by Volutella citrinella BF-0440
Keyword(s):
2D Nmr
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New terpendoles N-P (1–3) were isolated along with 8 structurally related known compounds including terpendoles and voluhemins from a culture broth of the fungus Volutella citrinella BF-0440. The structures of 1–3 were elucidated using various spectroscopic experiments including 1D- and 2D-NMR. All compounds 1–3 contained a common indole–diterpene backbone. Compounds 2 and 3 had 7 and 6 consecutive ring systems with an indole ring, respectively, whereas 1 had a unique indolinone plus 4 consecutive ring system. Compounds 2 and 3 inhibited both sterol O-acyltransferase 1 and 2 isozymes, but 1 lost the inhibitory activity. Structure–activity relationships of fungal indole–diterpene compounds are discussed.
1995 ◽
Vol 38
(12)
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pp. 2202-2216
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1995 ◽
Vol 38
(12)
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pp. 2217-2230
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Keyword(s):
1987 ◽
Vol 35
(4)
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pp. 479-483
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1985 ◽
Vol 38
(11)
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pp. 1564-1567
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2000 ◽
Vol 43
(12)
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pp. 2332-2349
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2017 ◽
Vol 12
(11)
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pp. 1934578X1701201