Synthesis and Evaluation of Some Uracil Nucleosides as Promising Anti-Herpes Simplex Virus 1 Agents
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Since herpes simplex virus type 1 (HSV-1) infection is so widespread, several antiviral drugs have been developed to treat it, among which are uracil nucleosides. However, there are major problems with the current medications such as severe side-effects and drug resistance. Here we present some newly synthesized cyclic and acyclic uracil nucleosides that showed very promising activity against HSV-1 compared to acyclovir.
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2002 ◽
Vol 76
(18)
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pp. 9232-9241
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The Herpes Simplex Virus Type 1 (HSV-1) Regulatory Protein ICP0 Interacts with and Ubiquitinates p53
2003 ◽
Vol 278
(38)
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pp. 36596-36602
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2004 ◽
Vol 78
(9)
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pp. 4599-4608
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2003 ◽
Vol 77
(5)
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pp. 3307-3311
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1996 ◽
Vol 55
(5)
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pp. 623
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