scholarly journals Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-a][1,3,5]triazines

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3540
Author(s):  
Jonathan Elie ◽  
Corinne Fruit ◽  
Thierry Besson
Keyword(s):  
Microwave Heating ◽  
Reaction Times ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Conventional Methods ◽  
Work Up

This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-a][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO2Et) and alkyl or (het)aryl groups. This study confirms the interest of combining the efficient heating obtained under dielectric microwave heating and the achievement of sequential one-pot reactions, avoiding the tedious work-up and purification of intermediate compounds, achieving sustainable synthesis processes. Considering usual conventional methods, this microwave protocol is featured by advantages in terms of yields, reaction times, and convenient gram scale synthesis.

scholarly journals One-Pot Synthesis of α-Substituted Acrylates

SynOpen ◽  
2018 ◽  
Vol 02 (02) ◽  
pp. 0161-0167
Author(s):  
Magdalini Matziari ◽  
Yixin Xie
Keyword(s):  
Amino Acids ◽  
Reaction Times ◽  
Synthetic Method ◽  
One Pot ◽  
Biologically Relevant ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Acrylic Esters ◽  
Natural Amino Acids ◽  
Work Up

A simple and efficient synthetic method towards α-substituted acrylic esters has been developed using the Horner–Wadsworth–Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as natural amino acids and other biologically relevant substituents. The use of mild conditions, inexpensive reagents, short reaction times and simple work-up and purification steps provides an effective and general alternative to cumbersome multistep and low-yielding procedures described to date.

Ultrasound promoted facile one pot synthesis of highly substituted pyran derivatives catalyzed by silica-coated magnetic NiFe2O4nanoparticle-supported H14[NaP5W30O110] under mild conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (99) ◽  
pp. 96644-96661 ◽  
Author(s):  
Behrooz Maleki ◽  
Mehdi Baghayeri ◽  
Sedigheh Ayazi Jannat Abadi ◽  
Reza Tayebee ◽  
Amir Khojastehnezhad
Keyword(s):  
Ultrasonic Method ◽  
Reaction Times ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Magnetically Separable Catalyst ◽  
P Application ◽  
Magnetically Separable ◽  
Work Up ◽  
Minimum Work

Application of ultrasonic method as a green source of energy to reduce the reaction times compared to conventional processes. NiFe2O4@SiO2–H14[NaP5W30O110] was used as magnetically separable catalyst for synthesis of pyrans with minimum work up.

scholarly journals Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-5,6-dihydro-1,3,5-triazine-2,4-diamines

2020 ◽  
Vol 16 ◽  
pp. 1706-1712
Author(s):  
Moustafa Sherief Moustafa ◽  
Ramadan Ahmed Mekheimer ◽  
Saleh Mohammed Al-Mousawi ◽  
Mohamed Abd-Elmonem ◽  
Hesham El-Zorba ◽  
...  
Keyword(s):  
Microwave Heating ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
X Ray ◽  
X Ray Crystallography ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
High Yields

An efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamine derivatives was developed by reacting 5-amino-1,2,3,4-tetrazole with aromatic aldehydes and cyanamide in pyridine under controlled microwave heating with high yields. X-ray crystallography confirmed the structure of the obtained products.

scholarly journals Versatile Microwave-Assisted and Lanthanum Chloride Catalysed Synthesis of Polysubstituted Imidazoles Using Urea/Thiourea as Benign Source of Ammonia

2012 ◽  
Vol 9 (4) ◽  
pp. 1773-1777 ◽  
Author(s):  
Mohammad Reza Manafi ◽  
Pedram Manafi ◽  
Mohammad Reza Kalaee
Keyword(s):  
Solvent Free ◽  
Lanthanum Chloride ◽  
Environmentally Benign ◽  
One Pot ◽  
Free Condition ◽  
Effective Catalyst ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Solvent Free Condition ◽  
Work Up

Lanthanum chloride was found to be an effective catalyst for the facile and one-pot synthesis of polysubstituted imidazoles under solvent free condition in excellent yields. This method elucidates urea/thiourea, as an environmentally benign source of ammonia for the synthesis of polysubstituted imidazoles. The work-up procedure is very simple and the products don’t require further purification.

A microwave assisted one pot synthesis of novel ammonium based dicationic ionic liquids

RSC Advances ◽  
2015 ◽  
Vol 5 (16) ◽  
pp. 12139-12143 ◽  
Author(s):  
Darshak R. Bhatt ◽  
Kalpana C. Maheria ◽  
Jigisha K. Parikh
Keyword(s):  
Ionic Liquids ◽  
Reaction Time ◽  
Present Method ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Dicationic Ionic Liquids ◽  
Conventional Methods

A greener one pot synthesis of novel ammonium based dicationic ionic liquids is carried out under microwave conditions. The present method provides a better yield and less reaction time compared to the conventional methods.

Microwave-Assisted and L-proline Catalysed Domino Cyclisation in an Aqueous Medium: A Rapid, Highly Efficient and Green Synthesis of Benzo[a]Phenazine Annulated Heterocycles

2016 ◽  
Vol 40 (12) ◽  
pp. 722-726 ◽  
Author(s):  
Afshin Yazdani-Elah-Abadi ◽  
Razieh Mohebat ◽  
Mehrnoosh Kangani
Keyword(s):  
Green Synthesis ◽  
Reaction Times ◽  
Aromatic Aldehydes ◽  
Heterocyclic Ring ◽  
One Pot ◽  
Microwave Assisted ◽  
Highly Efficient ◽  
High Yields ◽  
Work Up ◽  
Operational Simplicity

A highly efficient one-pot, two-step microwave-assisted procedure was applied for the rapid and green synthesis of benzo[a]phenazine annulated heterocyclic ring systems from the three- or four-component condensation reactions of 2-hydroxynaphthalene-1,4-dione, o-phenylenediamine, aromatic aldehydes and 1,3-indandione using L-proline as a bifunctional organocatalyst in water. This new procedure has a number of advantages such as high yields, very short reaction times, operational simplicity, simple work-up procedures and avoidance of hazardous or toxic catalysts and organic solvents. Moreover, the catalyst can be recovered and reused several times without much loss of its performance.

An Efficient Microwave-Assisted Propylphosphonic Anhydride (T3P®)-Mediated One-Pot Chromone Synthesis via Enaminones

Synlett ◽  
2018 ◽  
Vol 29 (08) ◽  
pp. 1087-1091 ◽  
Author(s):  
Manoranjan Behera ◽  
C. Balakrishna ◽  
Venu Kandula ◽  
Ramakrishna Gudipati ◽  
Satyanarayana Yennam ◽  
...  
Keyword(s):  
Microwave Heating ◽  
High Purity ◽  
Reaction Times ◽  
Efficient Synthesis ◽  
One Pot ◽  
First Report ◽  
Enamino Ketones ◽  
Microwave Assisted

An efficient synthesis of 4H-chromene-4-ones via enamino ketones, with cyclization by using T3P® under microwave heating is described. This is the first report for the synthesis of chromones by using T3P®. Significant features of this method include short reaction times and high-purity products.

A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 39324-39329 ◽  
Author(s):  
Billel Belhani ◽  
Malika Berredjem ◽  
Marc Le Borgne ◽  
Zouhair Bouaziz ◽  
Jacques Lebreton ◽  
...  
Keyword(s):  
Reaction Times ◽  
Ultrasound Irradiation ◽  
Solvent Free ◽  
One Pot ◽  
Mild Conditions ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
Work Up

A one-pot synthesis of novel α-sulfamidophosphonates is described via a three-component reaction under ultrasound irradiation, catalyst-free and solvent-free conditions. The synthesis has mild conditions, short reaction times, good yields and simple work-up procedures.

scholarly journals Microwave-assisted efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-2,3-dihydro-1,3,5-triazine-2,4-diamines

2020 ◽  
Author(s):  
Moustafa Moustafa ◽  
Ramadan Mekheimer ◽  
Saleh Al-Mousawi ◽  
Mohamed Abd-Elmonem ◽  
Hesham El-Zorba ◽  
...  
Keyword(s):  
Microwave Heating ◽  
Aromatic Aldehydes ◽  
One Pot ◽  
X Ray ◽  
X Ray Crystallography ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
High Yields

An efficient one-pot synthesis of N 2-(tetrazol-5-yl)-6-aryl/heteroaryl-1,3,5-triazine-2,4-diamine derivatives was developed by reacting 5-amino-1,2,3,4-tetrazole with aromatic aldehydes and cyanamide in pyridine under controlled microwave heating with high yields. X-ray crystallography confirmed the structure of obtained products.  

Microwave-assisted one-pot synthesis of pyrimido［4,5-b］quinolines derivatives

2013 ◽  
Vol 30 (6) ◽  
pp. 636-642
Author(s):  
Xueli Zhang ◽  
Zhilan Lin ◽  
Huiling Hu ◽  
Jiaxin He ◽  
Yuan Gao
Keyword(s):  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis
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