scholarly journals One-Pot Synthesis of α-Substituted Acrylates

SynOpen ◽  
2018 ◽  
Vol 02 (02) ◽  
pp. 0161-0167
Author(s):  
Magdalini Matziari ◽  
Yixin Xie
Keyword(s):  
Amino Acids ◽  
Reaction Times ◽  
Synthetic Method ◽  
One Pot ◽  
Biologically Relevant ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Acrylic Esters ◽  
Natural Amino Acids ◽  
Work Up

A simple and efficient synthetic method towards α-substituted acrylic esters has been developed using the Horner–Wadsworth–Emmons (HWE) reaction with HCHO after alkylation of phosphonoacetates in a one-pot reaction. This method allows the smooth introduction of various side-chains, such as natural amino acids and other biologically relevant substituents. The use of mild conditions, inexpensive reagents, short reaction times and simple work-up and purification steps provides an effective and general alternative to cumbersome multistep and low-yielding procedures described to date.

Ultrasound promoted facile one pot synthesis of highly substituted pyran derivatives catalyzed by silica-coated magnetic NiFe2O4nanoparticle-supported H14[NaP5W30O110] under mild conditions

RSC Advances ◽  
2016 ◽  
Vol 6 (99) ◽  
pp. 96644-96661 ◽  
Author(s):  
Behrooz Maleki ◽  
Mehdi Baghayeri ◽  
Sedigheh Ayazi Jannat Abadi ◽  
Reza Tayebee ◽  
Amir Khojastehnezhad
Keyword(s):  
Ultrasonic Method ◽  
Reaction Times ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
Magnetically Separable Catalyst ◽  
P Application ◽  
Magnetically Separable ◽  
Work Up ◽  
Minimum Work

Application of ultrasonic method as a green source of energy to reduce the reaction times compared to conventional processes. NiFe2O4@SiO2–H14[NaP5W30O110] was used as magnetically separable catalyst for synthesis of pyrans with minimum work up.

A one-pot three-component synthesis of novel α-sulfamidophosphonates under ultrasound irradiation and catalyst-free conditions

RSC Advances ◽  
2015 ◽  
Vol 5 (49) ◽  
pp. 39324-39329 ◽  
Author(s):  
Billel Belhani ◽  
Malika Berredjem ◽  
Marc Le Borgne ◽  
Zouhair Bouaziz ◽  
Jacques Lebreton ◽  
...  
Keyword(s):  
Reaction Times ◽  
Ultrasound Irradiation ◽  
Solvent Free ◽  
One Pot ◽  
Mild Conditions ◽  
Catalyst Free ◽  
One Pot Synthesis ◽  
Solvent Free Conditions ◽  
Three Component Reaction ◽  
Work Up

A one-pot synthesis of novel α-sulfamidophosphonates is described via a three-component reaction under ultrasound irradiation, catalyst-free and solvent-free conditions. The synthesis has mild conditions, short reaction times, good yields and simple work-up procedures.

scholarly journals One-pot synthesis of enantiomerically pure N-protected allylic amines from N-protected α-amino esters

2016 ◽  
Vol 12 ◽  
pp. 957-962 ◽  
Author(s):  
Gastón Silveira-Dorta ◽  
Sergio J Álvarez-Méndez ◽  
Víctor S Martín ◽  
José M Padrón
Keyword(s):  
Amino Acids ◽  
Allylic Amines ◽  
One Pot ◽  
Enantiomerically Pure ◽  
Amino Esters ◽  
One Pot Synthesis ◽  
Sequential Reduction ◽  
Natural Amino Acids ◽  
Hydroxy Groups

An improved protocol for the synthesis of enantiomerically pure allylic amines is reported. N-Protected α-amino esters derived from natural amino acids were submitted to a one-pot tandem reduction–olefination process. The sequential reduction with DIBAL-H at −78 °C and subsequent in situ addition of organophosphorus reagents yielded the corresponding allylic amines without the need to isolate the intermediate aldehyde. This circumvents the problem of instability of the aldehydes. The method tolerates well both Wittig and Horner–Wadsworth–Emmons organophosphorus reagents. A better Z-(dia)stereoselectivity was observed when compared to the previous one-pot method. The (dia)stereoselectivity of the process was affected neither by the reaction solvent nor by the amount of DIBAL-H employed. The method is compatible with the presence of free hydroxy groups as shown with serine and threonine derivatives.

scholarly journals A quadruple cascade protocol for the one-pot synthesis of fully-substituted hexahydroisoindolinones from simple substrates

2016 ◽  
Vol 12 ◽  
pp. 253-259 ◽  
Author(s):  
Hong-Bo Zhang ◽  
Yong-Chun Luo ◽  
Xiu-Qin Hu ◽  
Yong-Min Liang ◽  
Peng-Fei Xu
Keyword(s):  
Tertiary Amine ◽  
Good Yield ◽  
Synthetic Method ◽  
Atom Economy ◽  
One Pot ◽  
Mild Conditions ◽  
One Pot Synthesis ◽  
The One ◽  
Simple Manipulation

A new and efficient synthetic method to obtain fully-substituted hexahydroisoindolinones was developed by using bifunctional tertiary amine-thioureas as powerful catalysts. As far as we know, there is no efficient synthetic method developed toward fully-substituted hexahydroisoindolinones. The products were obtained in good yield and diastereoselectivity. The one-pot cascade quadruple protocol features readily available starting materials, simple manipulation, mild conditions and good atom economy.

scholarly journals Microwave-Assisted Sequential One-Pot Synthesis of 8-Substituted Pyrazolo[1,5-a][1,3,5]triazines

Molecules ◽  
2021 ◽  
Vol 26 (12) ◽  
pp. 3540
Author(s):  
Jonathan Elie ◽  
Corinne Fruit ◽  
Thierry Besson
Keyword(s):  
Microwave Heating ◽  
Reaction Times ◽  
One Pot ◽  
Microwave Assisted ◽  
One Pot Synthesis ◽  
Conventional Methods ◽  
Work Up

This paper reports a convenient sequential one-pot approach for the synthesis of an array of 14 pyrazolo[1,5-a][1,3,5]triazines, substituted in C8 by halogen (Br), various functions (CN and CO2Et) and alkyl or (het)aryl groups. This study confirms the interest of combining the efficient heating obtained under dielectric microwave heating and the achievement of sequential one-pot reactions, avoiding the tedious work-up and purification of intermediate compounds, achieving sustainable synthesis processes. Considering usual conventional methods, this microwave protocol is featured by advantages in terms of yields, reaction times, and convenient gram scale synthesis.

scholarly journals One-pot synthesis of polysubstituted indoles from aliphatic nitro compounds under mild conditions

2007 ◽  
Vol 48 (10) ◽  
pp. 1809-1811 ◽  
Author(s):  
Christopher A. Simoneau ◽  
Alexis M. Strohl ◽  
Bruce Ganem
Keyword(s):  
Nitro Compounds ◽  
One Pot ◽  
Aliphatic Nitro Compounds ◽  
Mild Conditions ◽  
One Pot Synthesis

One-Pot Synthesis of Sialo-Containing Glycosyl Amino Acids by Use of anN-Trichloroethoxycarbonyl-?-thiophenyl Sialoside

2005 ◽  
Vol 11 (3) ◽  
pp. 849-862 ◽  
Author(s):  
Hiroshi Tanaka ◽  
Masaatsu Adachi ◽  
Takashi Takahashi
Keyword(s):  
Amino Acids ◽  
One Pot ◽  
One Pot Synthesis

scholarly journals Synthesis of 2,4,6-triarylpyridines Using AlPO4 Under Solvent-free Conditions

2010 ◽  
Vol 2 (2) ◽  
pp. 337-342 ◽  
Author(s):  
P. Rajput ◽  
N. J. P. Subhashini ◽  
Shiva Raj
Keyword(s):  
Heterogeneous Catalyst ◽  
Simple Procedure ◽  
Reaction Times ◽  
Aluminum Phosphate ◽  
Solvent Free ◽  
One Pot ◽  
One Pot Synthesis ◽  
Solvent Free Conditions

A series of 2,4,6-triarylpyridines have been prepared using a variety of aromatic and heteroaromatic aldehydes in the presence of aluminum phosphate (AlPO4) as a heterogeneous catalyst at 120 oC under solvent-free conditions. The present methodology offers several advantages such as excellent yields, simple procedure, shorter reaction times, milder conditions and the catalyst exhibited remarkable reusable activity. Keywords: Aluminum phosphate; 2,4,6-triarylpyridines; One-pot synthesis; Shorter reaction times;  Reusable activity.  © 2010 JSR Publications. ISSN: 2070-0237 (Print); 2070-0245 (Online). All rights reserved. DOI: 10.3329/jsr.v2i2.3859               J. Sci. Res. 2 (2), 337-342 (2010) 

Rapid and Green One-Pot Synthesis of Novel 2-(4-Hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-diones

2021 ◽  
Vol 18 ◽  
Author(s):  
Abolfazl Olyaei ◽  
Zahra Ghahremany ◽  
Madieh Sadeghpour
Keyword(s):  
Aromatic Amines ◽  
Low Cost ◽  
Guanidine Hydrochloride ◽  
Reaction Times ◽  
Solvent Free ◽  
One Pot ◽  
Solvent Free Conditions ◽  
The One ◽  
High Yields ◽  
Work Up

: A green and efficient protocol was developed for the one-pot three-component synthesis of novel 2-(4-hydroxy-2-oxo-2H-chromen-3-yl)-2-(arylamino)-1H-indene-1,3(2H)-dione derivatives by the reaction of 4-hydroxycoumarin, ninhydrin and aromatic amines in the presence of guanidine hydrochloride as an organocatalyst under solvent-free conditions. The present approach offers several advantages such as low cost, simple work-up, short reaction times, chromatography-free purification, high yields and greener conditions.

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