Green synthesis of MIL-100(Fe) metal-organic frameworks as a carrier for chloroquine delivery

The metal-organic framework MIL-100(Fe) was synthesized by the green process using the ultrasonic method and water. By using this approach, the energy consumption was reduced by 100 times compared to the hydrothermal method. The prepared MIL-100(Fe) was characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and BET surface area measurements. The XRD pattern showed characteristic peaks of MIL-100 (Fe) with the main peaks at 6.3o, 10.3o, 11.1o, and 20.1o. The prepared MIL-100(Fe) was of particle size in a range of from 100 nm to 200 nm, and surface area of 950 m2/g with a pore volume of 0.52 cm3/g. The obtained MIL-100 (Fe) showed a high loading capacity for the chloroquine drug with a maximal capacity of 555 mg/g.

A finite-element-aided ultrasonic method for measuring central oil-film thickness in a roller-raceway tribo-pair

Roller bearings support heavy loads by riding on an ultra-thin oil film (between the roller and raceway), the thickness of which is critical as it reflects the lubrication performance. Ultrasonic interfacial reflection, which facilitates the non-destructive measurement of oil-film thickness, has been widely studied. However, insufficient spatial resolution around the rolling line contact zone remains a barrier despite the use of miniature piezoelectric transducers. In this study, a finite-element-aided method is utilized to simulate wave propagation through a three-layered structure of roller-oil-raceway under elastohydrodynamic lubrication (EHL) with nonlinear characteristics of the i) deformed curvature of the cylindrical roller and ii) nonuniform distribution of the fluid bulk modulus along the circumference of the oil layer being considered. A load and speed-dependent look-up table is then developed to establish an accurate relationship between the overall reflection coefficient (directly measured by an embedded ultrasonic transducer) and objective variable of the central oil-film thickness. The proposed finite-element-aided method is verified experimentally in a roller-raceway test rig with the ultrasonically measured oil-film thickness corresponding to the values calculated using the EHL theory.

Development of the technology of production of cheese ‘Suluguni’ for farms

The aim of the research is the development of a technology for the production of ‘Suluguni’ cheese for farms from milk of cows. Investigations of the chemical composition and physicochemical properties of cows’ milk were carried out using by ultrasonic method. It was found that the mass fraction of protein in milk is 3.19±0.02%, fat is from 4.32±0.06% to 5.07±0.08%. For the production of cheese, milk was standardized. The protein content in normalized milk is 3.37±0.02%, fat - 2.84±0.03%. The ratio of the mass fraction of protein and fat in normalized milk was 1.00:1.19. It was found that the milk of cows meets the requirements for raw materials for the production of cheese. We have developed a technology for the production of brine cheese ‘Suluguni’, which consists of the following operations: receiving milk, preparing milk for making cheese, fermenting, curdling and processing the curd, setting grain, drying, cheddaring, melting, forming a cheese head, salting, storing, transportation and sale of products. Cheese meets the requirements for organoleptic, physicochemical and microbiological indicators. The research results make it possible to recommend to farms the technology for the production of ‘Suluguni’ cheese with cheddaring and thermomechanical processing of the cheese mass.

Wear resistance discrete management of formative tool

The article is devoted to the organization of management of the application of wear-resistant materials on the formative tool at set intervals by the method of electro-acoustic spraying. A complex highly concentrated effect of the ultrasonic method in a permanent process, based on the pulse energy, which leads to an increase in the plasticity of the material and is not associated with its heating. The law of electro-plastic deformation for a conducting material, taking into account the high density of the acting amperage in the process of active deformation at a constant rate, considered in this article, establishes a clear dependence of the strengthening of the substrate material. The process of concentration of electromagnetic and thermal fields in a conductive material with defects such as a crack makes it possible to use this technology to slow down the propagation of cracks while reducing the concentration of mechanical stresses.

Sorafenib Nanomicelles Effectively Shrink Tumors by Vaginal Administration for Preoperative Chemotherapy of Cervical Cancer

To investigate the potential of sorafenib (SF) in preoperative chemotherapy for cervical cancer to reduce tumor volume, sorafenib micelles (SF micelles) with good stability and high drug loading were designed. SF micelles were prepared by film hydration followed by the ultrasonic method. The results showed that the SF micelles were spherical with an average particle size of 67.18 ± 0.66 nm (PDI 0.17 ± 0.01), a considerable drug loading of 15.9 ± 0.46% (w/w%) and satisfactory stability in buffers containing plasma or not for at least 2 days. In vitro release showed that SF was gradually released from SF micelles and almost completely released on the third day. The results of in vitro cellular intake, cytotoxicity and proliferation of cervical cancer cell TC-1 showed that SF micelles were superior to sorafenib (Free SF). For intravaginal administration, SF micelles were dispersed in HPMC (SF micelles/HPMC), showed good viscosity sustained-release profiles in vitro and exhibited extended residence in intravaginal in vivo. Compared with SF micelles dispersed in N.S. (SF micelles/N.S.), SF micelles/HPMC significantly reduced tumor size with a tumor weight inhibition rate of 73%. The results suggested that SF micelles had good potential for preoperative tumor shrinkage and improving the quality life of patients.

Green synthesis, characterization, biological evaluation and docking study of some pyrazoline and pyrimidine derivatives

Green and classical techniques have been utilized for preparing of a variety of aryl - substituted pyrazoline and pyrimidine derivatives (2-8). Reactions of chalcones 1 with semicarbazide and thiosemicarbazide, nicotinic acid hydrazide and amino guanidine hydrochloride afforded the corresponding N-substituted pyrazoline derivatives 2-5. Pyrimidine derivatives 6-8 were achieved via reaction of chalcone derivatives 1 with several reagents namely: guanidine nitrate, thiourea and 6-amino-2-thioxo-2,3- dihydropyrimidin-4(1H)-one under conventional and ultrasonic conditions. Ultrasonic method was found to be an easy work-up procedure and it gave high yield in comparison with conventional method. The structures of new synthesis compounds were characterized by elemental and spectral analyses. Some of newly compounds were tested in vitro antibacterial activity against some gram–positive and gram–negative. The antimicrobial results displayed favorable antimicrobial activity. Molecular docking has been perfomed for compound 5b using MOE 2008.10, The data results obtained are quite promising.