scholarly journals Design, Synthesis, Antibacterial, and Antitumor Activity of Linear Polyisocyanide Quaternary Ammonium Salts with Different Structures and Chain Lengths

Molecules ◽  
2021 ◽  
Vol 26 (18) ◽  
pp. 5686
Author(s):  
Hongguang Zhang ◽  
Lijia Liu ◽  
Peng Hou ◽  
Jun Liu ◽  
Shuang Fu

The development of organic polymer materials for disinfection and sterilization is thought of as one of the most promising avenues to solve the growth and spread of harmful microorganisms. Here, a series of linear polyisocyanide quaternary ammonium salts (L-PQASs) with different structures and chain lengths were designed and synthesized by polymerization of phenyl isocyanide monomer containing a 4-chloro-1-butyl side chain followed by quaternary amination salinization. The resultant compounds were characterized by 1H NMR and FT-IR. The antibacterial activity of L-PQASs with different structures and chain lengths against Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) was evaluated by determining the minimum inhibitory concentrations (MICs). The L-POcQAS-M50 has the strongest antimicrobial activity with MICs of 27 μg/mL against E. coli and 32 μg/mL against S. aureus. When the L-PQASs had the same polymerization degree, the order of the antibacterial activity of the L-PQASs was L-POcQAS-Mn > L-PBuQAS-Mn > L-PBnQAS-Mn > L-PDBQAS-Mn (linear, polyisocyanide quaternary ammonium salt, monomer, n = 50,100). However, when L-PQASs had the same side chain, the antibacterial activity reduced with the increase of the molecular weight of the main chain. These results demonstrated that the antibacterial activity of L-PQASs was dependent on the structure of the main chain and the length of the side chain. In addition, we also found that the L-POcQAS-M50 had a significant killing effect on MK-28 gastric cancer cells.

2018 ◽  
Vol 9 (37) ◽  
pp. 4611-4616 ◽  
Author(s):  
Jiangna Guo ◽  
Jing Qin ◽  
Yongyuan Ren ◽  
Bin Wang ◽  
Hengqing Cui ◽  
...  

Imidazolium (Im), quaternary ammonium (Qa), and 1,4-diazabicyclo[2.2.2]octane-1,4-diium (DABCO-diium) cation-based small molecule cationic compounds and their corresponding side-chain/main-chain cationic polymers were synthesized.


2015 ◽  
Vol 293 (7) ◽  
pp. 1971-1981 ◽  
Author(s):  
Xiao Cui ◽  
Congde Qiao ◽  
Shijie Wang ◽  
Yunqiao Ding ◽  
Chuanming Hao ◽  
...  

2013 ◽  
Vol 350 (2) ◽  
pp. 190-198 ◽  
Author(s):  
Ewa Obłąk ◽  
Agata Piecuch ◽  
Katarzyna Guz-Regner ◽  
Ewa Dworniczek

Author(s):  
Rocky Barney ◽  
Tony Stark ◽  
Dru Delaet

Quaternary ammonium salts (otherwise known as quats) are commonly used active ingredients in biocide formulations used in the anti-microbial industry. Although quats have been established to be effective biocides, there are few studies investigating the maximization of biocidal efficacy in multiple component formulations using various carbon chain lengths. Reported here is the synthesis based on the Sn2 reaction of tertiary amines with alkyl bromide. Surfactant studies of the single and dual component systems were conducted, and the evaluation is explored.


RSC Advances ◽  
2015 ◽  
Vol 5 (76) ◽  
pp. 61742-61751 ◽  
Author(s):  
Li Qun Xu ◽  
Ning Ning Li ◽  
Jiu Cun Chen ◽  
Guo Dong Fu ◽  
En-Tang Kang

Polymeric quaternary ammonium salts-functionalized agarose not only exhibit good antibacterial activity in solution form, but also can be solidified to construct antibacterial surfaces.


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