scholarly journals Fishing of α-Glucosidase’s Ligands from Aloe vera by α-Glucosidase Functionalized Magnetic Nanoparticles

Molecules ◽  
2021 ◽  
Vol 26 (19) ◽  
pp. 5840
Author(s):  
Hao Yuan ◽  
Hong Wan ◽  
Yi-Kao Hu ◽  
Emmanuel Ayodeji Ayeni ◽  
Qiang Chang ◽  
...  

α-Glucosidase was immobilized on magnetic nanoparticles (MNPs) for selective solid-phase extraction of the enzyme’s ligands present in Aloe vera, which is a medicinal plant used for the treatment of various diseases and possesses anti-diabetic activity. One new compound, aloeacone (2), together with two known compounds, aloenin aglycone (1) and aloin A (3), were fished out as the enzyme’s ligands. The structure of 2 was determined by HR-MS and comprehensive NMR techniques. Compound 3 exhibited a weak inhibitory effect on α-glucosidase, while compounds 1 and 2 were found to possess activation effects on the enzyme for the first time. It is interesting that both an inhibitor and agonists of α-glucosidase were fished out in one experiment.

RSC Advances ◽  
2017 ◽  
Vol 7 (66) ◽  
pp. 41862-41868 ◽  
Author(s):  
Maosheng Zhang ◽  
Guobin Huang ◽  
Jiarong Huang ◽  
Ling Zhong ◽  
Weilan Chen

Novel octahedral structured Fe3O4@SiO2@polydimethylsiloxane magnetic nanoparticles (Fe3O4@SiO2@PDMS MNPs) have been successfully synthesized for the first time.


Talanta ◽  
2016 ◽  
Vol 153 ◽  
pp. 228-239 ◽  
Author(s):  
Elisa Vereda Alonso ◽  
M.M. López Guerrero ◽  
Pilar Colorado Cueto ◽  
José Barreno Benítez ◽  
José Manuel Cano Pavón ◽  
...  

2019 ◽  
Vol 1082 ◽  
pp. 37-48 ◽  
Author(s):  
Mario Daniel Contin ◽  
Jose Enrico Quinsaat ◽  
R. Martín Negri ◽  
Valeria Paula Tripodi ◽  
Dorina Opris ◽  
...  

2015 ◽  
Vol 7 (21) ◽  
pp. 9054-9063 ◽  
Author(s):  
Zhihong Yan ◽  
Genhua Zhu ◽  
Ying Cai ◽  
Jinbin Yuan ◽  
Shouzhuo Yao

Magnetic solid-phase extraction for the enrichment of PFCs from sample solution.


2019 ◽  
Vol 11 (13) ◽  
pp. 1735-1742 ◽  
Author(s):  
Jing-yan Kang ◽  
Wei Ha ◽  
Hai-xia Zhang ◽  
Yan-ping Shi

A novel magnetic adsorbent for Pb2+ was synthesized based on 4′-aminobenzo-18-crown-6 (AB18C6) and Fe3O4–CHO via the Mannich reaction. It showed excellent adsorption and selectivity for Pb2+, and the established MSPE method had excellent potential, displaying the selective determination of trace Pb2+ from apples, milk and rice.


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