scholarly journals Briarane-Related Diterpenoids from Octocoral Briareum stechei

Molecules ◽  
2021 ◽  
Vol 26 (22) ◽  
pp. 6861
Author(s):  
Thanh-Hao Huynh ◽  
Choo-Aun Neoh ◽  
Yu-Chi Tsai ◽  
Zhi-Kang Yao ◽  
Li-Guo Zheng ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Mouse Macrophage ◽  
Inos Protein ◽  
New Compounds ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

A known polyoxygenated briarane, briaexcavatolide P (1), was isolated from a Formosan octocoral Briareum stechei. Moreover, the same species B. stechei, collected from Okinawan waters, yielded three chlorine-containing briaranes, including two new compounds, briastecholides B (2) and C (3) as well as a known analogue, briarenol R (4). The structures of 1–4 were established using spectroscopic methods. In addition, briarane 1 demonstrated anti-inflammatory activity in lipo-polysaccharide-induced RAW 264.7 mouse macrophage cells by suppressing the expression of inducible nitric oxide synthase (iNOS) protein.

scholarly journals Briarenols I—K, New Anti-inflammatory 8,17-Epoxybriaranes from the Octocoral Briareum excavatum (Briareidae)

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1405 ◽  
Author(s):  
Thanh-Hao Huynh ◽  
Lee-Shing Fang ◽  
Yu-Hsin Chen ◽  
Bo-Rong Peng ◽  
You-Ying Chen ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Inducible Nitric Oxide Synthase ◽  
2D Nmr ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Nmr Studies ◽  
Cox 2 ◽  
New Compounds ◽  
Oxide Synthase ◽  
Inducible Nitric Oxide

Five 8,17-epoxybriaranes, including three new compounds—briarenols I–K (1–3), along with two known analogues, briaexcavatolide P (4) and briaexcavatin P (5), were isolated from the octocoral Briareum excavatum. The structures of briaranes 1–3 were elucidated by spectroscopic methods, including 1D and 2D NMR studies and (+)-HRESIMS. Briarane 4 exerted inhibition effects on inducible nitric oxide synthase (iNOS) and cyclooxygenase-2 (COX-2) release from RAW 264.7.

scholarly journals Briarenols Q–T: Briaranes from A Cultured Octocoral Briareum stechei (Kükenthal, 1908)

Marine Drugs ◽  
2020 ◽  
Vol 18 (8) ◽  
pp. 383
Author(s):  
Yi-Lin Zhang ◽  
Chih-Chao Chiang ◽  
Yi-Ting Lee ◽  
Zhi-Hong Wen ◽  
Yang-Chang Wu ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Nitric Oxide Synthase ◽  
Inducible Nitric Oxide Synthase ◽  
Chemical Study ◽  
Raw 264.7 ◽  
Spectroscopic Methods ◽  
Oxide Synthase ◽  
Continuous Chemical ◽  
Inducible Nitric Oxide ◽  
New Metabolites

Our continuous chemical study of a cultured octocoral Briareum stechei led to the isolation of four new briarane diterpenoids, briarenols Q–T (1–4). The structures of new metabolites 1–4 were established by spectroscopic methods, and compounds 3 and 4 were found to inhibit the generation of inducible nitric oxide synthase (iNOS) from RAW 264.7 stimulated by lipopolysaccharides (LPS).

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