scholarly journals Sensing the Anti-Epileptic Drug Perampanel with Paper-Based Spinning SERS Substrates

Molecules ◽  
2021 ◽  
Vol 27 (1) ◽  
pp. 30
Author(s):  
Andrea Macrelli ◽  
Nicolò Simone Villa ◽  
Andrea Lucotti ◽  
David Dellasega ◽  
Paolo Maria Ossi ◽  
...  
Keyword(s):  
Hard Disk Drives ◽  
Cost Effective ◽  
Spare Part ◽  
Therapeutic Drug ◽  
Disk Drives ◽  
Sers Substrates ◽  
Heating Effects ◽  
Anti Epileptic Drug ◽  
Vis Spectroscopy ◽  
Experimental Approaches

The applications of SERS in therapeutic drug monitoring, or other fields of analytical chemistry, require the availability of sensitive sensors and experimental approaches that can be implemented in affordable ways. In this contribution, we show the production of cost-effective SERS sensors obtained by depositing Lee-Meisel Ag colloids on filter paper either by natural sedimentation or centrifugation. We have characterized the morphological and plasmonic features of the sensors by optical microscopy, SEM, and UV-Vis spectroscopy. Such sensors can be used to quantify by SERS the anti-epileptic drug Perampanel (in the concentration range 1 × 10−4–5 × 10−6 M) by spinning them during the micro-Raman measurements on the top of a custom device obtained from spare part hard disk drives. This approach minimizes laser-induced heating effects and allows averaging over the spatial non-uniformity of the sensor.

Control of Dual-Stage HDDs With Enhanced Repetitive Disturbance Rejection

2017 ◽  
Author(s):  
Shiying Zhou ◽  
Minghui Zheng ◽  
Xu Chen ◽  
Masayoshi Tomizuka
Keyword(s):  
Data Storage ◽  
Disturbance Rejection ◽  
Hard Disk Drives ◽  
Cost Effective ◽  
Error Tolerance ◽  
Disk Drives ◽  
Control Performance ◽  
Solid State Drives ◽  
Control Task ◽  
Dual Stage

Nowadays, despite the emerging adoption of the solid state drives, hard disk drives (HDDs) are still used extensively as cost-effective and reliable solutions for data storage. In addition to its usual application in desktops and laptops, HDDs become the primary storage medium for the data centers. The track following control task in HDD requires that the read/write head be positioned over the data track center at nano-scale accuracy, which requires an error tolerance about 7nm. Therefore, the dual-stage HDD is introduced to enhance the HDD control performance for extended bandwidth and improved disturbance rejection.

scholarly journals Characterization of Ultra-Thin Diamond-Like Carbon Films by SEM/EDX

Coatings ◽  
2021 ◽  
Vol 11 (6) ◽  
pp. 729
Author(s):  
Chanida Puttichaem ◽  
Guilherme P. Souza ◽  
Kurt C. Ruthe ◽  
Kittipong Chainok
Keyword(s):  
Regression Models ◽  
Hard Disk Drives ◽  
Carbon Films ◽  
Diamond Like Carbon ◽  
Disk Drives ◽  
Cross Sectional ◽  
Protective Films ◽  
High Throughput Method ◽  
Multiple Regression Models

A novel, high throughput method to characterize the chemistry of ultra-thin diamond-like carbon films is discussed. The method uses surface sensitive SEM/EDX to provide substrate-specific, semi-quantitative silicon nitride/DLC stack composition of protective films extensively used in the hard disk drives industry and at Angstrom-level. SEM/EDX output is correlated to TEM to provide direct, gauge-capable film thickness information using multiple regression models that make predictions based on film constituents. The best model uses the N/Si ratio in the films, instead of separate Si and N contributions. Topography of substrate/film after undergoing wear is correlatively and compositionally described based on chemical changes detected via the SEM/EDX method without the need for tedious cross-sectional workflows. Wear track regions of the substrate have a film depleted of carbon, as well as Si and N in the most severe cases, also revealing iron oxide formation. Analysis of film composition variations around industry-level thicknesses reveals a complex interplay between oxygen, silicon and nitrogen, which has been reflected mathematically in the regression models, as well as used to provide valuable insights into the as-deposited physics of the film.

Doing More With Less: Pragmatic Implementation of Vancomycin Area-Under-the-Curve (AUC) Monitoring

2021 ◽  
pp. 089719002110272
Author(s):  
Joanne Huang ◽  
Jeannie D. Chan ◽  
Thu Nguyen ◽  
Rupali Jain ◽  
Zahra Kassamali Escobar
Keyword(s):  
Quality Improvement ◽  
High Risk ◽  
Therapeutic Drug Monitoring ◽  
Paradigm Shift ◽  
Area Under The Curve ◽  
Cost Effective ◽  
Practical Method ◽  
Therapeutic Drug ◽  
Short Term ◽  
Quality Improvement Process

Universal area-under-the-curve (AUC) guided vancomycin therapeutic drug monitoring (TDM) is resource-intensive, cost-prohibitive, and presents a paradigm shift that leaves institutions with the quandary of defining the preferred and most practical method for TDM. We report a step-by-step quality improvement process using 4 plan-do-study-act (PDSA) cycles to provide a framework for development of a hybrid model of trough and AUC-based vancomycin monitoring. We found trough-based monitoring a pragmatic strategy as a first-tier approach when anticipated use is short-term. AUC-guided monitoring was most impactful and cost-effective when reserved for patients with high-risk for nephrotoxicity. We encourage others to consider quality improvement tools to locally adopt AUC-based monitoring.

scholarly journals Examining the feasibility of the urban mining of hard disk drives

2020 ◽  
Vol 248 ◽  
pp. 119216
Author(s):  
Laura Talens Peiró ◽  
Alejandra Castro Girón ◽  
Xavier Gabarrell i Durany
Keyword(s):  
Hard Disk Drives ◽  
Hard Disk ◽  
Disk Drives ◽  
Urban Mining

scholarly journals Evaluation of Vibration Characteristics of Suspensions for Hard Disk Drives and Reducing the Vibration by Using Viscoelastic Dampers.

2002 ◽  
Vol 68 (667) ◽  
pp. 720-727 ◽  
Author(s):  
Hiromitsu MASUDA ◽  
Toshihiko SHIMIZU ◽  
Mikio TOKUYAMA ◽  
Haruhide TAKAHASHI ◽  
Kousaku WAKATSUKI ◽  
...  
Keyword(s):  
Hard Disk Drives ◽  
Hard Disk ◽  
Vibration Characteristics ◽  
Disk Drives ◽  
Viscoelastic Dampers

Feasibility study of thermal positioning control actuator for hard disk drives

2012 ◽  
Vol 18 (9-10) ◽  
pp. 1383-1388 ◽  
Author(s):  
Masaru Furukawa ◽  
Junguo Xu ◽  
Jin Liu ◽  
Jianhua Li ◽  
Shoya Nosaki ◽  
...  
Keyword(s):  
Feasibility Study ◽  
Hard Disk Drives ◽  
Hard Disk ◽  
Disk Drives ◽  
Positioning Control

Analysis of Electrical Resonance of a Hard Disk Drives Suspension Interconnect and Invasion Into Read Signal Path

2014 ◽  
Vol 50 (11) ◽  
pp. 1-4 ◽  
Author(s):  
Nobumasa Nishiyama ◽  
Yuji Soga ◽  
Kazuniro Nagaoka ◽  
Tomohisa Okada ◽  
John T. Contreras ◽  
...  
Keyword(s):  
Hard Disk Drives ◽  
Hard Disk ◽  
Disk Drives ◽  
Electrical Resonance ◽  
Signal Path ◽  
Read Signal

Comparative characterisation of two fulvic acids from East Lake and Liangzi Lake in central China

2015 ◽  
Vol 12 (2) ◽  
pp. 189 ◽  
Author(s):  
Jun Wang ◽  
Huijie Li ◽  
Yong Chen ◽  
Yuan Fang ◽  
Zongping Wang ◽  
...  
Keyword(s):  
Fluorescence Spectroscopy ◽  
Cost Effective ◽  
Fulvic Acids ◽  
Central China ◽  
Anthropogenic Activity ◽  
Cost Effective Method ◽  
Vis Spectroscopy ◽  
East Lake ◽  
Ft Ir ◽  
Eem Fluorescence

Environmental context Fulvic acids account for a large proportion of dissolved organic matter in aquatic environments and affect the transportation and bioavailability of organic and inorganic pollutants. The structural and spectroscopic characteristics of fulvic acids mainly depend on the sources, seasons and anthropogenic activity. We present an advanced approach using fluorescence spectroscopy as a rapid and cost-effective method to investigate the composition, properties and origins of fulvic acids. Abstract Fulvic acids (FAs) isolated seasonally from the sediments of East Lake and Liangzi Lake in central China were comparatively investigated. The structural features of the FAs were characterised using chemical and spectroscopic methods, including elemental analysis, UV-Vis spectroscopy, Fourier-transform infrared (FT-IR) spectroscopy, and three-dimensional excitation emission matrix (EEM) fluorescence spectroscopy coupled with parallel factor analysis (PARAFAC). The O/C, (O+N)/C and C/N ratios of FA extracted from Liangzi Lake (FAL) were higher than those of FA extracted from East Lake (FAE), indicating higher oxygen-containing functionality and polarity and less nutrient in FAL compared with FAE. The two FAs had similar UV-Vis spectra with different absorbance intensities. The FT-IR spectra showed that the two FAs had similar functional groups. The total fluorescence intensity and aromaticity of samples from Liangzi Lake were higher than those of East Lake except for those taken in the summer. The two FAs were largely terrestrially derived organic materials. Five fluorescent components, including four humic-like and two fulvic-like components, were identified by PARAFAC modelling of the EEM spectral data. The fluorescence was dominated by two components. The findings suggest that EEM fluorescence spectroscopy together with PARAFAC is a rapid and cost-effective method for understanding the characteristics and origins of FAs in natural water systems.

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