scholarly journals Surface-Enhanced Raman Scattering-Based Lateral-Flow Immunoassay

Nanomaterials ◽  
2020 ◽  
Vol 10 (11) ◽  
pp. 2228
Author(s):  
Boris Khlebtsov ◽  
Nikolai Khlebtsov
Keyword(s):  
Raman Scattering ◽  
Point Of Care ◽  
Surface Enhanced Raman Scattering ◽  
Environmental Safety ◽  
Lateral Flow ◽  
Wide Range ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Low Sensitivity

Lateral flow immunoassays (LFIAs) have been developed and used in a wide range of applications, in point-of-care disease diagnoses, environmental safety, and food control. However, in its classical version, it has low sensitivity and can only perform semiquantitative detection, based on colorimetric signals. Over the past decade, surface-enhanced Raman scattering (SERS) tags have been developed in order to decrease the detection limit and enable the quantitative analysis of analytes. Of note, these tags needed new readout systems and signal processing algorithms, while the LFIA design remained unchanged. This review highlights SERS strategies of signal enhancement for LFIAs. The types of labels used, the possible gain in sensitivity from their use, methods of reading and processing the signal, and the prospects for use are discussed.

A surface-enhanced Raman scattering-based lateral flow immunosensor for colistin in raw milk

2019 ◽  
Vol 282 ◽  
pp. 703-711 ◽  
Author(s):  
Yu Li ◽  
Shusheng Tang ◽  
Wanjun Zhang ◽  
Xiaojin Cui ◽  
Yuxin Zhang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Raw Milk ◽  
Surface Enhanced Raman Scattering ◽  
Lateral Flow ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering

scholarly journals Duplex Surface Enhanced Raman Scattering-Based Lateral Flow Immunosensor for the Low-Level Detection of Antibiotic Residues in Milk

Molecules ◽  
2020 ◽  
Vol 25 (22) ◽  
pp. 5249
Author(s):  
Ruiqi Fan ◽  
Shusheng Tang ◽  
Sunlin Luo ◽  
Hu Liu ◽  
Wanjun Zhang ◽  
...  
Keyword(s):  
Raman Scattering ◽  
Simultaneous Detection ◽  
Surface Enhanced Raman Scattering ◽  
Lateral Flow ◽  
Antibiotic Residues ◽  
Relative Standard ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Enhanced Raman Scattering ◽  
Analytical Approaches

A duplex surface enhanced Raman scattering (SERS)-based lateral flow immunosensor was established for the simultaneous detection of two common antibiotic residues including tetracycline and penicillin in milk. The newly synthesized Au@Ag nanoparticles were labeled with different Raman molecules including 5,5-dithiobis-2-nitrobenzoic acid (DTNB) or 4-mercaptobenzoic acid (MBA), followed by the conjugation of anti-tetracycline monoclonal antibody or anti-penicillin receptor, forming two kinds of SERS nanoprobes. The two nanoprobes can recognize tetracycline-BSA and ampicillin-BSA, respectively, which facilitates the simultaneous detection of the two types of antibiotics on a single test line. After optimization, detection limits of tetracycline and penicillin as low as 0.015 ng/mL and 0.010 ng/mL, respectively, were achieved. These values were far below those of most of other documented bio-analytical approaches. Moreover, the spiking test demonstrates an excellent assay accuracy with recoveries of 88.8% to 111.3%, and satisfactory assay precision with relative standard deviation below 16%. Consequently, the results demonstrate that the SERS-based lateral flow immunosensor developed in this study has the advantages of excellent assay sensitivity and remarkable multiplexing capability, thus it will have great application potential in food safety monitoring.

Visible-light and near-infrared fluorescence and surface-enhanced Raman scattering point-of-care sensing and bio-imaging: a review

2022 ◽  
Author(s):  
Yingjie Hang ◽  
Jennifer Boryczka ◽  
Nianqiang Wu
Keyword(s):  
Raman Scattering ◽  
Visible Light ◽  
Near Infrared ◽  
Point Of Care ◽  
Surface Enhanced Raman Scattering ◽  
Near Infrared Fluorescence ◽  
Surface Enhanced ◽  
Surface Enhanced Raman ◽  
Bio Imaging ◽  
Enhanced Raman Scattering

This article reviews the principles, design and applications of visible-light and near-infrared fluorescence and surface-enhanced Raman scattering in point-of-care testing and bio-imaging.

Sign in / Sign up

Export Citation Format

Share Document