scholarly journals Micellar Iron Oxide Nanoparticles Coated with Anti-Tumor Glycosides

Nanomaterials ◽  
2018 ◽  
Vol 8 (8) ◽  
pp. 567 ◽  
Author(s):  
Hugo Groult ◽  
Isabel García-Álvarez ◽  
Lorenzo Romero-Ramírez ◽  
Manuel Nieto-Sampedro ◽  
Fernando Herranz ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Rat Glioma ◽  
Antimitotic Activity ◽  
Theranostic Agents

The synthesis procedure of nanoparticles based on thermal degradation produces organic solvent dispersible iron oxide nanoparticles (OA-IONP) with oleic acid coating and unique physicochemical properties of the core. Some glycosides with hydrophilic sugar moieties bound to oleyl hydrophobic chains have antimitotic activity on cancer cells but reduced in vivo applications because of the intrinsic low solubility in physiological media, and are prone to enzymatic hydrolysis. In this manuscript, we have synthetized and characterized OA-IONP-based micelles encapsulated within amphiphilic bioactive glycosides. The glycoside-coated IONP micelles were tested as Magnetic Resonance Imaging (MRI) contrast agents as well as antimitotics on rat glioma (C6) and human lung carcinoma (A549) cell lines. Micelle antimitotic activity was compared with the activity of the corresponding free glycosides. In general, all OA-IONP-based micellar formulations of these glycosides maintained their anti-tumor effects, and, in one case, showed an unusual therapeutic improvement. Finally, the micelles presented optimal relaxometric properties for their use as T2-weighed MRI contrast agents. Our results suggest that these bioactive hydrophilic nano-formulations are theranostic agents with synergistic properties obtained from two entities, which separately are not ready for in vivo applications, and strengthen the possibility of using biomolecules as both a coating for OA-IONP micellar stabilization and as drugs for therapy.

scholarly journals Iron Oxide Nanoparticles as Theranostic Agents in Cancer Immunotherapy

Nanomaterials ◽  
2021 ◽  
Vol 11 (8) ◽  
pp. 1950
Author(s):  
Rossella Canese ◽  
Federica Vurro ◽  
Pasquina Marzola
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Cancer Immunotherapy ◽  
Iron Oxide Nanoparticles ◽  
Imaging Techniques ◽  
Macrophage Polarization ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Diagnostic Potential ◽  
Theranostic Agents

Starting from the mid-1990s, several iron oxide nanoparticles (NPs) were developed as MRI contrast agents. Since their sizes fall in the tenths of a nanometer range, after i.v. injection these NPs are preferentially captured by the reticuloendothelial system of the liver. They have therefore been proposed as liver-specific contrast agents. Even though their unfavorable cost/benefit ratio has led to their withdrawal from the market, innovative applications have recently prompted a renewal of interest in these NPs. One important and innovative application is as diagnostic agents in cancer immunotherapy, thanks to their ability to track tumor-associated macrophages (TAMs) in vivo. It is worth noting that iron oxide NPs may also have a therapeutic role, given their ability to alter macrophage polarization. This review is devoted to the most recent advances in applications of iron oxide NPs in tumor diagnosis and therapy. The intrinsic therapeutic effect of these NPs on tumor growth, their capability to alter macrophage polarization and their diagnostic potential are examined. Innovative strategies for NP-based drug delivery in tumors (e.g., magnetic resonance targeting) will also be described. Finally, the review looks at their role as tracers for innovative, and very promising, imaging techniques (magnetic particle imaging-MPI).

Synthesis of Iron Oxide Nanoparticles Used as MRI Contrast Agents: A Parametric Study

1999 ◽  
Vol 212 (2) ◽  
pp. 474-482 ◽  
Author(s):  
Lucia Babes ◽  
Benoı̂t Denizot ◽  
Gisèle Tanguy ◽  
Jean Jacques Le Jeune ◽  
Pierre Jallet
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Parametric Study ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast

scholarly journals Iron oxide nanoparticles stabilized with dendritic polyglycerols as selective MRI contrast agents

Nanoscale ◽  
2014 ◽  
Vol 6 (16) ◽  
pp. 9646-9654 ◽  
Author(s):  
Daniel Nordmeyer ◽  
Patrick Stumpf ◽  
Dominic Gröger ◽  
Andreas Hofmann ◽  
Sven Enders ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Iron Oxide ◽  
Contrast Agent ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Superparamagnetic Iron Oxide ◽  
Mri Contrast Agents ◽  
Mri Contrast Agent ◽  
Oxide Nanoparticles ◽  
Mri Contrast

Superparamagnetic iron oxide nanoparticles with a dendritic polyglycerol (dPG) sulfate strongly bind to L- and P-selectin. Shielding of leukocytes reduces cell extravasation and binding to endothelial cells indicate inflammation specificity and thus, applicability as selective MRI contrast agent.

scholarly journals PEG-copolymer-coated iron oxide nanoparticles that avoid the reticuloendothelial system and act as kidney MRI contrast agents

Nanoscale ◽  
2018 ◽  
Vol 10 (29) ◽  
pp. 14153-14164 ◽  
Author(s):  
Vanessa Gómez-Vallejo ◽  
María Puigivila ◽  
Sandra Plaza-García ◽  
Boguslaw Szczupak ◽  
Rafael Piñol ◽  
...  
Keyword(s):  
Iron Oxide ◽  
Contrast Agents ◽  
Iron Oxide Nanoparticles ◽  
Reticuloendothelial System ◽  
Mri Contrast Agents ◽  
Oxide Nanoparticles ◽  
Mri Contrast ◽  
Gamma Counting ◽  
Magnetic Nanocarriers

PEG coated magnetic nanocarriers avoid the reticuloendothelial system, and show an MRI contrast in the kidneys. The results are supported by SPECT, gamma-counting, MRI and TEM histology.

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