scholarly journals Immunomodulatory Effects of Glutathione, Garlic Derivatives, and Hydrogen Sulfide

Nutrients ◽  
2019 ◽  
Vol 11 (2) ◽  
pp. 295 ◽  
Author(s):  
Camila Rodrigues ◽  
Susan Percival
Keyword(s):  
Cardiovascular Disease ◽  
Hydrogen Sulfide ◽  
Aged Garlic Extract ◽  
Immunomodulatory Effects ◽  
Beneficial Effects ◽  
Health And Disease ◽  
Oxidative Processes ◽  
Sulfur Containing ◽  
Aged Garlic ◽  
Sulfur Containing Compounds

Glutathione and aged garlic extract are sulfur-containing products that play important protective and regulatory roles within the immune system and in oxidative processes. Hydrogen sulfide (H2S), an endogenous, gaseous, signaling transmitter, has also been shown to be involved in the regulation of inflammation. Recent studies have shown that sulfur-containing compounds from garlic have beneficial effects in attenuating outcomes associated with cardiovascular disease and inflammation by a mechanism that may be related to the H2S signaling pathway. In this review, we summarize the main functions of glutathione (GSH), garlic derivatives and H2S and their role in the immune response and impact on health and disease.

scholarly journals Potential Anticancer Effects of Aged Garlic Extract and its Water-soluble Organosulfur Compounds

2020 ◽  
pp. 108-121
Author(s):  
Huda Mohammed Alkreathy
Keyword(s):  
Water Soluble ◽  
Garlic Extract ◽  
Organosulfur Compounds ◽  
Aged Garlic Extract ◽  
Beneficial Effects ◽  
Anticancer Effects ◽  
Secondary Information ◽  
Ebsco Host ◽  
Healthcare Expenses ◽  
Aged Garlic

Background: Cancer is among the leading causes of morbidity and mortality globally; it often leads to a steep rise in healthcare expenses. It is a known fact that various dietary ingredients such as aged garlic is an active anticancer agent, and its extracts do not have a strong odor and pungent taste. Purpose: This review summarizes the potential beneficial effects of aged garlic extract (AGE) and its water-soluble organosulfur compounds on the cancer incidences, and in the prevention and improvement of malignancy factors. Methods: The study utilizes systematic reviews on publications of previous studies obtained from scholarly journal databases including PubMed, Medline, Ebsco Host, Google Scholar and Cochrane. The study utilizes secondary information based on the studies conducted in cancer cell lines, animal and humans as there are increasing evidence of the efficacy of AGE and AGE-derived water-soluble organosulfur compounds in cancer and other malignancies. Conclusion and Recommendation: Although animal and laboratory results were mostly consistent, there is variable evidence from human studies. The overall findings suggest that consumption of AGE and AGE-derived organosulfur compounds can offer significant protection against cancer. In our review, we found that there are shortcomings in various studies. Therefore, we recommend that more investigations are necessary to establish whether aged garlic extract could be considered for cancer prevention.

scholarly journals Immunomodulatory Effects of Aged Garlic Extract

2001 ◽  
Vol 131 (3) ◽  
pp. 1075S-1079S ◽  
Author(s):  
Eikai Kyo ◽  
Naoto Uda ◽  
Shigeo Kasuga ◽  
Yoichi Itakura
Keyword(s):  
Garlic Extract ◽  
Aged Garlic Extract ◽  
Immunomodulatory Effects ◽  
Aged Garlic

scholarly journals Aged Garlic Extract Reduces IL-6: A Double-Blind Placebo-Controlled Trial in Females with a Low Risk of Cardiovascular Disease

2021 ◽  
Vol 2021 ◽  
pp. 1-9
Author(s):  
Martiné Wlosinska ◽  
Ann-Christin Nilsson ◽  
Joanna Hlebowicz ◽  
Mohammed Fakhro ◽  
Malin Malmsjö ◽  
...  
Keyword(s):  
Cardiovascular Disease ◽  
Ct Scan ◽  
Risk Score ◽  
Blood Lipids ◽  
Framingham Risk Score ◽  
Controlled Trial ◽  
Aged Garlic Extract ◽  
Double Blind ◽  
Framingham Risk ◽  
Aged Garlic

Background. Chronic inflammation is a risk factor for cardiovascular disease. The aim of the study was to evaluate whether a daily supplementation of aged garlic extract (AGE) could reduce inflammation in females with low risk for cardiovascular disease. The study was conducted at a single center, as a parallel randomized placebo-controlled trial. Method. 63 females with a Framingham risk score over 10 underwent cardiac computed tomography (CT) scan. Of those, patients with a coronary artery calcium (CAC) scores less than 5 (n = 31) met the inclusion criteria and were randomized, in a double-blind manner to an intake of placebo or AGE (2400 mg daily) for 1 year. Results. Main outcome measure was changes in inflammatory biomarkers, blood pressure, fastening blood glucose, and blood lipids. A total of 29 patients (14 in the AGE group and 15 in the placebo group) completed the study and were analyzed. Females treated with AGE showed lower levels of inflammatory marker IL-6 after 12 months of treatment compared to females receiving placebo ( p < 0.05 ). The blood lipids had a trend towards a lowering effect in females treated with AGE; however, this trend was not significant. Conclusion. The present study concludes that AGE lowers IL-6 in females with a risk profile of cardiovascular disease. We could also conclude that risk prediction with cardiac CT  scan turned out to be superior in estimating the risk of cardiac disease compared to Framingham risk score. This trial is registered with NCT03860350.

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