scholarly journals A Systematic Review of Genetic Polymorphisms Associated with Binge Eating Disorder

Nutrients ◽  
2021 ◽  
Vol 13 (3) ◽  
pp. 848
Author(s):  
Lucia Manfredi ◽  
Alessandra Accoto ◽  
Alessandro Couyoumdjian ◽  
David Conversi
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Genetic Polymorphisms ◽  
Binge Eating Disorder ◽  
Observational Studies ◽  
Web Of Science ◽  
Bibliographic Databases ◽  
Research Groups ◽  
Eligibility Criteria

The genetic polymorphisms involved in the physiopathology of binge eating disorder (BED) are currently unclear. This systematic review aims to highlight and summarize the research on polymorphisms that is conducted in the BED. We looked for observational studies where there was a genetic comparison between adults with BED, in some cases also with obesity or overweight, and healthy controls or obesity/overweight without BED. Our protocol was written using PRISMA. It is registered at PROSPERO (identification: CRD42020198645). To identify potentially relevant documents, the following bibliographic databases were searched without a time limit, but until September 2020: PubMed, PsycINFO, Scopus, and Web of Science. In total, 21 articles were included in the qualitative analysis of the systematic review, as they met the eligibility criteria. Within the selected studies, 41 polymorphisms of 17 genes were assessed. Overall, this systematic review provides a list of potentially useful genetic polymorphisms involved in BED: 5-HTTLPR (5-HTT), Taq1A (ANKK1/DRD2), A118G (OPRM1), C957T (DRD2), rs2283265 (DRD2), Val158Met (COMT), rs6198 (GR), Val103Ile (MC4R), Ile251Leu (MC4R), rs6265 (BNDF), and Leu72Met (GHRL). It is important to emphasize that Taq1A is the polymorphism that showed, in two different research groups, the most significant association with BED. The remaining polymorphisms need further evidence to be confirmed.

Antidepressants in short-term treatment of binge eating disorder: Systematic review and meta-analysis

2008 ◽  
Vol 9 (2) ◽  
pp. 129-136 ◽  
Author(s):  
Sérgio Carlos Stefano ◽  
Josué Bacaltchuk ◽  
Sérgio Luís Blay ◽  
José Carlos Appolinário
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Meta Analysis ◽  
Term Treatment ◽  
Short Term ◽  
Short Term Treatment

Food-related impulsivity in obesity and Binge Eating Disorder - a systematic review

2013 ◽  
Vol 14 (6) ◽  
pp. 477-495 ◽  
Author(s):  
K. Schag ◽  
J. Schönleber ◽  
M. Teufel ◽  
S. Zipfel ◽  
K. E. Giel
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder

scholarly journals A Systematic Review of Obesity and Binge Eating Associated Impairment of the Cognitive Inhibition System

2021 ◽  
Vol 8 ◽  
Author(s):  
Elodie Saruco ◽  
Burkhard Pleger
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Neural Circuits ◽  
Brain Regions ◽  
Cognitive Inhibition ◽  
Significant Impairment ◽  
Disinhibited Eating ◽  
The Brain

Altered functioning of the inhibition system and the resulting higher impulsivity are known to play a major role in overeating. Considering the great impact of disinhibited eating behavior on obesity onset and maintenance, this systematic review of the literature aims at identifying to what extent the brain inhibitory networks are impaired in individuals with obesity. It also aims at examining whether the presence of binge eating disorder leads to similar although steeper neural deterioration. We identified 12 studies that specifically assessed impulsivity during neuroimaging. We found a significant alteration of neural circuits primarily involving the frontal and limbic regions. Functional activity results show BMI-dependent hypoactivity of frontal regions during cognitive inhibition and either increased or decreased patterns of activity in several other brain regions, according to their respective role in inhibition processes. The presence of binge eating disorder results in further aggravation of those neural alterations. Connectivity results mainly report strengthened connectivity patterns across frontal, parietal, and limbic networks. Neuroimaging studies suggest significant impairment of various neural circuits involved in inhibition processes in individuals with obesity. The elaboration of accurate therapeutic neurocognitive interventions, however, requires further investigations, for a deeper identification and understanding of obesity-related alterations of the inhibition brain system.

Systematic review of the effects of acute stress in binge eating disorder

2018 ◽  
Vol 50 (3) ◽  
pp. 2415-2429 ◽  
Author(s):  
Katherine R. Naish ◽  
Michele Laliberte ◽  
James MacKillop ◽  
Iris M. Balodis
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Acute Stress

scholarly journals Scrutinizing Domains of Executive Function in Binge Eating Disorder: A Systematic Review and Meta-Analysis

2020 ◽  
Vol 11 ◽  
Author(s):  
Maria Elisa Gisbert Cury ◽  
Arthur Berberian ◽  
Bruno Sini Scarpato ◽  
Jess Kerr-Gaffney ◽  
Flavia H. Santos ◽  
...  
Keyword(s):  
Systematic Review ◽  
Executive Function ◽  
Eating Disorder ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Meta Analysis

scholarly journals Dialectical Behaviour Therapy Improves Emotion Dysregulation Mainly in Binge Eating Disorder and Bulimia Nervosa: A Systematic Review and Meta-Analysis

2021 ◽  
Vol 11 (9) ◽  
pp. 931
Author(s):  
Natalia Rozakou-Soumalia ◽  
Ştefana Dârvariu ◽  
Jan Magnus Sjögren
Keyword(s):  
Systematic Review ◽  
Eating Disorder ◽  
Bulimia Nervosa ◽  
Binge Eating ◽  
Binge Eating Disorder ◽  
Emotion Dysregulation ◽  
Meta Analysis ◽  
Control Group ◽  
Behaviour Therapy ◽  
Dialectical Behaviour Therapy

Emotion dysregulation is a transdiagnostic phenomenon in Eating Disorders (ED), and Dialectical Behaviour Therapy (DBT) (which was developed for reducing dysregulated emotions in personality disorders) has been employed in patients with ED. This systematic review and meta-analysis investigated whether the effect of DBT was stronger on emotion dysregulation, general psychopathology, and Body Mass Index (BMI) in participants with ED, when compared to a control group (active therapy and waitlist). Eleven studies were identified in a systematic search in accordance with PRISMA guidelines. Most studies included participants with Binge Eating Disorder (BED) (n = 8), some with Bulimia Nervosa (BN) (n = 3), and only one with Anorexia Nervosa (AN). The pooled effect of DBT indicated a greater improvement in Emotion Regulation (ER) (g = −0.69, p = 0.01), depressive symptoms (g = −0.33, p < 0.00001), ED psychopathology (MD = −0.90, p = 0.005), Objective Binge Episodes (OBE) (MD = −0.27, p = 0.003), and BMI (MD = −1.93, p = 0.01) compared to the control group. No improvement was detected in eating ER following DBT (p = 0.41). DBT demonstrated greater efficacy compared with the control group in improving emotion dysregulation, ED psychopathology, and BMI in ED. The limitations included the small number of studies and high variability.

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