scholarly journals Heated Corn Oil and 2,4-Decadienal Suppress Gastric Emptying and Energy Intake in Humans

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1304
Author(s):  
Hideaki Kashima ◽  
Ayumi Honma ◽  
Saori Kamimura ◽  
Saki Nishimura ◽  
Takashi Sano ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Healthy Volunteers ◽  
Energy Intake ◽  
Breath Test ◽  
Corn Oil ◽  
Test Experiment ◽  
Heated Oil ◽  
Rate Experiment

Consumption of 2,4-decadienal (2,4-DD) delays gastric emptying (GE) rate in animals. Oil heating produces 2,4-DD and other aldehydes. Here we examined whether heated oil affects GE rate and food intake in humans, and whether it is mediated by 2,4-DD. In the first experiment, 10 healthy volunteers consumed 240-g pumpkin soup with 9.2 g of heated (HO) or non-heated corn oil (CO). Subsequently, 17 participants consumed pumpkin soup containing 3.1 g of either heated corn oil (HO), 1 mg 2,4-DD + non-heated corn oil (2,4-DD), or non-heated corn oil (CO). Sixty minutes following pumpkin soup, cod roe spaghetti was provided, and then energy intake was determined. To evaluate GE rate, 13C breath test (Experiment 1) and ultrasonography (Experiments 1 and 2) were used. The results from the Experiment 1 confirmed that consumption of heated corn oil reduced GE rate. Experiment 2 showed a delayed GE rate in HO and 2,4-DD trials compared with CO trial (p < 0.05). Energy intake was approximately 600–650 kJ lower in HO and 2,4-DD trials compared with CO trial (p < 0.05). These findings suggest that 2,4-DD, either formed by oil heating or added to food, contributes to suppressing GE rate and energy intake.

A study of gastric emptying in H. pylori negative healthy volunteers using the 13C-octanoic acid breath test

2000 ◽  
Vol 118 (4) ◽  
pp. A1169 ◽  
Author(s):  
Shigeyuki Ebara ◽  
Nobuo Aoyama ◽  
Toshiyuki Sakai ◽  
Takahiro Ikemura ◽  
Daisuke Shirasaka ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Breath Test ◽  
Octanoic Acid ◽  
H Pylori

Satiating effect of fat in diabetic rats: gastrointestinal and postabsorptive factors

1988 ◽  
Vol 255 (1) ◽  
pp. R123-R127
Author(s):  
N. K. Edens ◽  
M. I. Friedman
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Corn Oil ◽  
Ketone Bodies ◽  
Stomach Contents ◽  
Diabetic Rats ◽  
Physiological Basis ◽  
Streptozotocin Diabetic Rats ◽  
Fat Feeding ◽  
Fat Meal

Streptozotocin-diabetic rats decrease food intake more than normal animals in response to a fat test meal. To determine the physiological basis of this differential response, we examined the effects of an ingested corn oil meal on food intake, gastrointestinal fill, and plasma triglycerides, glycerol, and ketone bodies. Hyperphagic diabetic rats decreased intake of a high-carbohydrate, low-fat stock diet starting 2-4 h after the fat meal, whereas normal rats did not. Gastric emptying was accelerated and intestinal mass and contents were increased in diabetic rats. The fat meal reduced gastric emptying and increased stomach contents in diabetic and normal rats starting within 2 h of ingestion. Intestinal fill decreased in diabetic animals after the oil meal. Triglycerides and glycerol increased transiently after fat ingestion in normal and diabetic rats, whereas ketone body concentrations rose only in diabetic rats starting 1-3 h after fat ingestion. The results indicate that the differential effect of a fat meal on food intake in normal and diabetic rats is related to differences in the postabsorptive metabolism of the ingested fat rather than to effects of fat feeding on gastrointestinal fill or clearance.

Comparison of two mathematical programmes in evaluation of the 13C-octanoic acid breath test for gastric emptying in healthy volunteers

2001 ◽  
Vol 120 (5) ◽  
pp. A466-A466 ◽  
Author(s):  
T DOUDA ◽  
J BURES ◽  
M KOPACOVA ◽  
V VORISEK ◽  
J BUKAC ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Breath Test ◽  
Octanoic Acid

Inhibition of food intake in response to intestinal lipid is mediated by cholecystokinin in humans

1999 ◽  
Vol 277 (6) ◽  
pp. R1718-R1724 ◽  
Author(s):  
Daniel Matzinger ◽  
Jean-Pierre Gutzwiller ◽  
Juergen Drewe ◽  
Amar Orban ◽  
Reto Engel ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Food Intake ◽  
Receptor Antagonist ◽  
Energy Intake ◽  
Calorie Intake ◽  
Double Blind ◽  
Crossover Studies ◽  
Early Satiation ◽  
Male Subjects

Intraduodenal fat inhibits gastric emptying and exerts early satiation in animals and humans, but it is not clear whether the effects are mediated by cholecystokinin (CCK) in humans. Here, we tested whether CCK-A receptors mediate the inhibition of fat on food intake. Two sequential, double-blind, crossover studies were performed in 24 male subjects. First, subjects received either intraduodenal fat or saline together with a preload of either water or banana shake. Second, 12 subjects received either intraduodenal fat or saline perfusion plus a concomitant infusion of saline or loxiglumide, a specific CCK-A receptor antagonist, together with a preload of banana shake. In both studies, subjects were free to eat and drink as much as they wished. Fat induced a reduction in calorie intake ( P < 0.05) compared with controls. Furthermore, a decrease in hunger feelings was observed. Infusion of loxiglumide abolished the effects of fat. Duodenal fat interacts with an appetizer to modulate energy intake in humans. This effect is mediated by CCK-A receptors.

Effects of glucose supplementation on gastric emptying, blood glucose homeostasis, and appetite in the elderly

2001 ◽  
Vol 280 (2) ◽  
pp. R570-R576 ◽  
Author(s):  
Katherine Beckoff ◽  
Caroline G. MacIntosh ◽  
Ian M. Chapman ◽  
Judith M. Wishart ◽  
Howard A. Morris ◽  
...  
Keyword(s):  
Blood Glucose ◽  
Gastric Emptying ◽  
Food Intake ◽  
Energy Intake ◽  
Glucose Homeostasis ◽  
Gastric Inhibitory Polypeptide ◽  
Postprandial Blood Glucose ◽  
Blood Glucose Homeostasis ◽  
Older Subjects ◽  
Glucose Supplementation

The aims of this study were to evaluate the effects of dietary glucose supplementation on gastric emptying (GE) of both glucose and fat, postprandial blood glucose homeostasis, and appetite in eight older subjects (4 males, 4 females, aged 65–84 yr). GE of a drink (15 ml olive oil and 33 g glucose dissolved in 185 ml water), blood glucose, insulin, gastric inhibitory polypeptide (GIP) and glucagon-like peptide-1 (GLP-1), and appetite (diet diaries, visual analog scales, and food intake at a buffet meal consumed after the GE study) were evaluated twice, after 10 days on a standard or a glucose-supplemented diet (70 g glucose 3 times a day). Glucose supplementation accelerated GE of glucose ( P < 0.05), but not oil; there was a trend for an increase in GIP (at 15 min, P = 0.06), no change in GLP-1, an earlier insulin peak ( P < 0.01), and a subsequent reduction in blood glucose (at 75 min, P < 0.01). Glucose supplementation had no effect on food intake during each diet so that energy intake was greater ( P < 0.001) during the glucose-supplemented diet. Appetite ratings and energy intake at the buffet meal were not different. We conclude that, in older subjects, glucose supplementation 1) accelerates GE of glucose, but not fat; 2) modifies postprandial blood glucose homeostasis; and 3) increases energy intake.

Comparison of two mathematical programmes in evaluation of the 13C-octanoic acid breath test for gastric emptying in healthy volunteers

2001 ◽  
Vol 120 (5) ◽  
pp. A466
Author(s):  
Tomas Douda ◽  
Jan Bures ◽  
Marcela Kopacova ◽  
Viktor Vorisek ◽  
Jan Bukac ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Breath Test ◽  
Octanoic Acid

scholarly journals Sa1344 Study of Gastric Emptying and Digestive Function With 13C Octanoic Acid Breath Test in Non Dyspeptic Healthy Volunteers

2014 ◽  
Vol 146 (5) ◽  
pp. S-268
Author(s):  
Giovanni Bruno ◽  
Loris Riccardo Lopetuso ◽  
Gianluca Ianiro ◽  
Lucrezia Laterza ◽  
Viviana Gerardi ◽  
...  
Keyword(s):  
Gastric Emptying ◽  
Healthy Volunteers ◽  
Breath Test ◽  
Octanoic Acid ◽  
Digestive Function
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