scholarly journals Associations of Serum Magnesium with Brain Morphology and Subclinical Cerebrovascular Disease: The Atherosclerosis Risk in Communities-Neurocognitive Study

Nutrients ◽  
2021 ◽  
Vol 13 (12) ◽  
pp. 4496
Author(s):  
Aniqa B. Alam ◽  
DaNashia S. Thomas ◽  
Pamela L. Lutsey ◽  
Srishti Shrestha ◽  
Alvaro Alonso
Keyword(s):  
Cerebrovascular Disease ◽  
Serum Magnesium ◽  
Elevated Serum ◽  
Brain Morphology ◽  
White Matter Hyperintensity ◽  
Atherosclerosis Risk In Communities ◽  
Lower Odds ◽  
Lacunar Infarcts ◽  
Total Brain ◽  
Atherosclerosis Risk

Circulating magnesium has been associated with a lower risk of dementia, but the physiologic effects by which magnesium may prevent neurological insults remain unclear. We studied 1466 individuals (mean age 76.2 ± 5.3, 28.8% black, 60.1% female) free of prevalent stroke, with measured serum magnesium and with available MRI scans obtained in 2011–2013, participating in the Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS). Cross-sectional differences in frontal, temporal, parietal, and occipital lobe volume, along with deep grey matter, total brain, and white matter hyperintensity volume across serum magnesium (categorized into quintiles and per standard deviation increases) were assessed using multiple linear regression. We also examined associations of magnesium with the prevalence of cortical, subcortical, and lacunar infarcts using multiple logistic regression. After adjusting for demographics, biomarkers, medications, and cardiometabolic risk factors, higher circulating magnesium was associated with greater total brain volume and frontal, temporal, and parietal lobe volumes (volumes 0.14 to 0.19 standard deviations higher comparing Q5 to Q1). Elevated magnesium was also associated with lower odds of subcortical infarcts (OR (95%CI): 0.44 (0.25, 0.77) comparing Q5 to Q1) and lacunar infarcts (OR (95%CI): 0.40 (0.22, 0.71) comparing Q5 to Q1). Elevated serum magnesium was cross-sectionally associated with greater brain volumes and lower odds of subclinical cerebrovascular disease, suggesting beneficial effects on pathways related to neurodegeneration and cerebrovascular damage. Further exploration through prospective analyses is needed to assess increasing circulating magnesium as a potential neuroprotective intervention.

scholarly journals Results from the Atherosclerosis Risk in Communities study suggest that low serum magnesium is associated with incident kidney disease

2015 ◽  
Vol 87 (4) ◽  
pp. 820-827 ◽  
Author(s):  
Adrienne Tin ◽  
Morgan E. Grams ◽  
Nisa M. Maruthur ◽  
Brad C. Astor ◽  
David Couper ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Serum Magnesium ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Low Serum

scholarly journals Serum magnesium and risk of sudden cardiac death in the Atherosclerosis Risk in Communities (ARIC) Study

2010 ◽  
Vol 160 (3) ◽  
pp. 464-470 ◽  
Author(s):  
James M. Peacock ◽  
Tetsuya Ohira ◽  
Wendy Post ◽  
Nona Sotoodehnia ◽  
Wayne Rosamond ◽  
...  
Keyword(s):  
Sudden Cardiac Death ◽  
Cardiac Death ◽  
Serum Magnesium ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk ◽  
Aric Study

scholarly journals Serum magnesium, bone–mineral metabolism markers and their interactions with kidney function on subsequent risk of peripheral artery disease: the Atherosclerosis Risk in Communities Study

2020 ◽  
Vol 35 (11) ◽  
pp. 1878-1885 ◽  
Author(s):  
Steven Menez ◽  
Ning Ding ◽  
Morgan E Grams ◽  
Pamela L Lutsey ◽  
Gerardo Heiss ◽  
...  
Keyword(s):  
Kidney Function ◽  
Peripheral Artery Disease ◽  
Bone Mineral ◽  
Mineral Metabolism ◽  
Serum Magnesium ◽  
Peripheral Artery ◽  
Atherosclerosis Risk In Communities ◽  
Bone Mineral Metabolism ◽  
Atherosclerosis Risk ◽  
Artery Disease

Abstract Background Few studies have investigated the association of magnesium levels with incident peripheral artery disease (PAD) despite emerging evidence of magnesium contributing to vascular calcification. Moreover, no data are available on whether the magnesium–PAD relationship is independent of or modified by kidney function. Methods A cohort of 11 839 participants free of PAD in the Atherosclerosis Risk in Communities Study at Visit 2 (1990–92) was studied. We investigated the association of serum magnesium and other bone–mineral metabolism markers [calcium, phosphorus, intact parathyroid hormone (iPTH) and intact fibroblast growth factor-23] with incident PAD using multivariable Cox proportional hazards regression. Results Over a median of 23 years, there were 471 cases of incident PAD. The hazard ratio for incident PAD in Quartile 1 (<1.5 mEq/L) versus Quartile 4 (>1.7 mEq/L) of magnesium was 1.96 (95% confidence interval 1.40–2.74) after adjustment for potential confounders. Lower magnesium levels were associated with greater incidence of PAD, particularly in those with estimated glomerular filtration rate (eGFR) ≥60 mL/min/1.73 m2 (n = 11 606). In contrast, the association was largely flat in those with eGFR <60 mL/min/1.73 m2 (n = 233) with P-for-interaction 0.03. Among bone–mineral metabolism markers, only higher iPTH showed an interaction with kidney function (P-for-interaction 0.01) and iPTH >65 pg/mL was significantly related to PAD only in those with eGFR <60 mL/min/1.73 m2. Conclusions Lower magnesium was independently associated with incident PAD, but this association was significantly weaker in those with reduced kidney function. In contrast, higher iPTH levels were particularly related to PAD risk in this clinical population.

scholarly journals Plasma Metabolites Associated with Brain MRI Measures of Neurodegeneration in Older Adults in the Atherosclerosis Risk in Communities–Neurocognitive Study (ARIC-NCS)

2019 ◽  
Vol 20 (7) ◽  
pp. 1744
Author(s):  
Danni Li ◽  
Jeffrey Misialek ◽  
Clifford Jack ◽  
Michelle Mielke ◽  
David Knopman ◽  
...  
Keyword(s):  
Older Adults ◽  
Physical Function ◽  
Brain Volume ◽  
Brain Mri ◽  
Plasma Metabolites ◽  
Total Brain Volume ◽  
Atherosclerosis Risk In Communities ◽  
Mri Features ◽  
Total Brain ◽  
Atherosclerosis Risk

Background: Plasma metabolites are associated with cognitive and physical function in the elderly. Because cerebral small vessel disease (SVD) and neurodegeneration are common causes of cognitive and physical function decline, the primary objective of this study was to investigate the associations of six plasma metabolites (two plasma phosphatidylcholines [PCs]: PC aa C36:5 and PC aa 36:6 and four sphingomyelins [SMs]: SM C26:0, SM [OH] C22:1, SM [OH] C22:2, SM [OH] C24:1) with magnetic resonance imaging (MRI) features of cerebral SVD and neurodegeneration in older adults. Methods: This study included 238 older adults in the Atherosclerosis Risk in Communities study at the fifth exam. Multiple linear regression was used to assess the association of each metabolite (log-transformed) in separate models with MRI measures except lacunar infarcts, for which binary logistic regression was used. Results: Higher concentrations of plasma PC aa C36:5 had adverse associations with MRI features of cerebral SVD (odds ratio of 1.69 [95% confidence interval: 1.01, 2.83] with lacunar infarct, and beta of 0.16 log [cm3] [0.02, 0.30] with log [White Matter Hyperintensities (WMH) volume]) while higher concentrations of 3 plasma SM (OH)s were associated with higher total brain volume (beta of 12.0 cm3 [5.5, 18.6], 11.8 cm3 [5.0, 18.6], and 7.3 cm3 [1.2, 13.5] for SM [OH] C22:1, SM [OH] C22:2, and SM [OH] C24:1, respectively). Conclusions: This study identified associations between certain plasma metabolites and brain MRI measures of SVD and neurodegeneration in older adults, particularly higher SM (OH) concentrations with higher total brain volume.

scholarly journals Diabetes, Prediabetes, and Brain Volumes and Subclinical Cerebrovascular Disease on MRI: The Atherosclerosis Risk in Communities Neurocognitive Study (ARIC-NCS)

Diabetes Care ◽  
2017 ◽  
Vol 40 (11) ◽  
pp. 1514-1521 ◽  
Author(s):  
Andrea L.C. Schneider ◽  
Elizabeth Selvin ◽  
A. Richey Sharrett ◽  
Michael Griswold ◽  
Josef Coresh ◽  
...  
Keyword(s):  
Cerebrovascular Disease ◽  
Brain Volumes ◽  
Atherosclerosis Risk In Communities ◽  
Atherosclerosis Risk
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