scholarly journals Synergistic Effects of Korean Red Ginseng Extract and the Conventional Systemic Therapeutics of Atopic Dermatitis in a Murine Model

Nutrients ◽  
2021 ◽  
Vol 14 (1) ◽  
pp. 133
Author(s):  
Yu Ri Woo ◽  
Seok Hoon Moon ◽  
Jeesuk Yu ◽  
Sang Hyun Cho
Keyword(s):  
Atopic Dermatitis ◽  
Synergistic Effects ◽  
Transepidermal Water Loss ◽  
Evening Primrose Oil ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Extract ◽  
Evening Primrose ◽  
Group A ◽  
Ad Mouse Model

The synergistic effects of Korean Red ginseng (KRG, Panax ginseng C.A. Mey.) on conventional systemic therapeutics of atopic dermatitis (AD) have not been studied yet. To analyze the synergistic effects of KRG extract and the conventional systemic therapeutics of AD in TNCB-induced AD mouse model, we determined the change in modified scoring of index, the transepidermal water loss, the skin pathology, serum IgE, and the expression of various cytokines after combination treatment to the five-week-old NC/Nga female mice. The severity of AD was significantly decreased in the KRG + hydroxyzine (AH) group than AH group, and in the KRG + evening primrose oil (EPO) group than EPO group. A significant decrease in dermal inflammation was observed in the KRG + AH group than that in the AH group, and in the KRG + EPO group than that in the EPO group (p = 0.008), respectively. A decrease in CD1a expression was observed in the KRG + AH group when compared to the AH group (p = 0.008), and KRG + EPO group when compared to the EPO group. Compared to the CS group, the KRG + CS group showed a significant decrease in IL-17 expression. A combination of KRG and conventional systemic therapeutics can safely and effectively manage the AD.

scholarly journals Effects of Korean Red Ginseng Extract for the Treatment of Atopic Dermatitis-Like Skin Lesions in Mice

2011 ◽  
Vol 35 (4) ◽  
pp. 479-486 ◽  
Author(s):  
Eun-Hwa Sohn ◽  
Seon-A Jang ◽  
Chul-Hoon Lee ◽  
Ki-Hyo Jang ◽  
Se-Chan Kang ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Skin Lesions ◽  
Red Ginseng ◽  
Korean Red Ginseng ◽  
Ginseng Extract

Inhibitory Effects of Korean Red Ginseng Extract on Atopic Dermatitis in NC/Nga Mice

2010 ◽  
Vol 26 (3) ◽  
pp. 265
Author(s):  
Hyo-Sang Kim ◽  
Tae-Ho Oh ◽  
Jae-Chan Song ◽  
Dae-Ik Kim ◽  
Ae-Kyung Lim ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Red Ginseng ◽  
Inhibitory Effects ◽  
Korean Red Ginseng ◽  
Ginseng Extract

scholarly journals Improved Hygroscopicity and Bioavailability of Solid Dispersion of Red Ginseng Extract with Silicon Dioxide

Pharmaceutics ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 1022
Author(s):  
Sojeong Jin ◽  
Chul Haeng Lee ◽  
Dong Yu Lim ◽  
Jaehyeok Lee ◽  
Soo-Jin Park ◽  
...  
Keyword(s):  
Silicon Dioxide ◽  
Intestinal Permeability ◽  
Solid Dispersion ◽  
Ussing Chamber ◽  
Red Ginseng ◽  
Scanning Calorimetry ◽  
Korean Red Ginseng ◽  
Ginseng Extract ◽  
Powder Formulation ◽  
Significant Difference

This study aims to develop a powder formulation for the Korean red ginseng extract (RGE) and to evaluate its in vitro and in vivo formulation characteristics. The solid dispersion of RGE was prepared with hydrophilic carriers using a freeze-drying method. After conducting the water sorption–desorption isothermogram (relative humidity between 30 and 70% RH), differential scanning calorimetry thermal behavior, dissolution test, and intestinal permeation study, a solid dispersion formulation of RGE and silicon dioxide (RGE-SiO2) was selected. RGE-SiO2 formulation increased intestinal permeability of ginsenoside Rb1 (GRb1), GRb2, GRc, and GRd by 1.6-fold in rat jejunal segments as measured by the Ussing chamber system. A 1.6- to 1.8-fold increase in plasma exposure of GRb1, GRb2, GRc, and GRd in rats was observed following oral administration of RGE-SiO2 (375 mg/kg as RGE). No significant difference was observed in the time to reach maximum concentration (Tmax) and half-life in comparison to those in RGE administered rats (375 mg/kg). In conclusion, formulating solid dispersion of RGE with amorphous SiO2, the powder formulation of RGE was successfully formulated with improved hygroscopicity, increased intestinal permeability, and enhanced oral bioavailability and is therefore suitable for processing solid formulations of RGE product.

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