High Seroprevalence of Hepatitis E Virus Infection Among East Balkan Swine (Sus scrofa) in Bulgaria: Preliminary Results

The East Balkan swine (Sus scrofa) is the only aboriginal pig breed in Bulgaria, and it is indigenous to the eastern part of the country. The aim of the present study was to investigate East Balkan swine (EBS) in Bulgaria for serological evidence of hepatitis E virus (HEV). Sera from 171 swine from two parts of the country (northeastern and southeastern) were tested for anti-HEV IgG antibodies. The overall HEV seroprevalence was 82.5% (141/171), and for weaners it was 77.2% (44/57), for fattening pigs 79.0% (45/57), and for adults 91.2% (52/57). HEV positivity was higher in fattening pigs and adults compared to weaners: OR = 1.108 (95% CI: 0.456–2.692) and OR = 3.073 (95% CI: 1.016–9.294), respectively. This study provides the first evidence of exposure to HEV in EBS from Bulgaria.

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High seroprevalence against hepatitis E virus in patients with chronic hepatitis C virus infection

Journal of Clinical Virology ◽

10.1016/j.jcv.2017.01.005 ◽

2017 ◽

Vol 88 ◽

pp. 39-45 ◽

Cited By ~ 11

Author(s):

Åsa Mellgren ◽

Miriam Karlsson ◽

Marie Karlsson ◽

Martin Lagging ◽

Rune Wejstål ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis C Virus ◽

Hepatitis C ◽

Virus Infection ◽

Chronic Hepatitis C ◽

Hepatitis E Virus ◽

Hepatitis E ◽

Hepatitis C Virus Infection ◽

High Seroprevalence ◽

Chronic Hepatitis C Virus

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Serological Evidence for Hepatitis E Virus Infection in Laboratory Monkeys and Pigs in Animal Facilities in Japan

Experimental Animals ◽

10.1538/expanim.57.367 ◽

2008 ◽

Vol 57 (4) ◽

pp. 367-376 ◽

Cited By ~ 15

Author(s):

Hiroshi YAMAMOTO ◽

Tian-Cheng LI ◽

Chihiro KOSHIMOTO ◽

Kaori ITO ◽

Masakazu KITA ◽

...

Keyword(s):

Virus Infection ◽

Hepatitis E Virus ◽

Hepatitis E ◽

Serological Evidence

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Community-Based Seroepidemiological Survey of Hepatitis E Virus Infection in Catalonia, Spain

Clinical and Vaccine Immunology ◽

10.1128/cvi.00255-06 ◽

2006 ◽

Vol 13 (12) ◽

pp. 1328-1332 ◽

Cited By ~ 61

Author(s):

Maria Buti ◽

Àngela Domínguez ◽

Pere Plans ◽

Rossend Jardí ◽

Mélani Schaper ◽

...

Keyword(s):

Virus Infection ◽

Rural Areas ◽

Hepatitis E Virus ◽

Multiple Logistic Regression Analysis ◽

Population Sample ◽

Hepatitis E ◽

Bivariate Analysis ◽

Igg Antibodies ◽

Clinical Variables ◽

Minor Surgery

ABSTRACT The objective of the study was to investigate the prevalence of immunoglobulin G (IgG) antibodies to hepatitis E virus (HEV) infection in a population sample from Catalonia and to analyze the demographic and clinical variables associated with the presence of these antibodies. A total of 1,280 subjects between 15 and 74 years of age were selected randomly from urban and rural areas. Data for sociodemographic and clinical variables were collected by using a questionnaire. IgG antibodies to HEV were determined by an immunoenzymatic method. The odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated for studied variables. Multiple logistic regression analysis was used to determine which variables were independently associated with the prevalence of HEV infection. Anti-HEV antibodies were detected in 96 (7.3%) of the 1,280 samples analyzed. The prevalence of antibodies was greater among males (7.8%) than among women (7%) and increased with age for both sexes, from 3% among subjects 15 to 24 years of age to 12% among subjects ≥65 years of age. Bivariate analysis of the sociodemographic and clinical variables showed an association between the prevalence of hepatitis E virus infection and minor surgery (OR, 1.96; 95% CI, 1.24 to 3.11), abdominal surgery (OR, 1.74; 95% CI, 1.12 to 2.73), and, for women, being uniparous or multiparous (OR, 2.84; 95% CI, 1.19 to 6.79). The multivariate analysis showed an association with minor surgery only (OR, 1.68; 95% CI, 1.03 to 2.70). In conclusion, anti-HEV antibodies were detected in 7.3% of the Catalan population. The seroprevalence of anti-HEV antibodies increased with age and was associated with previous minor surgery.

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Serological evidence and public health implication of hepatitis E virus infection in pigs found in Zaria, Kaduna State

African Journal of Microbiology Research ◽

10.5897/ajmr2015.7555 ◽

2015 ◽

Vol 9 (46) ◽

pp. 2270-2274 ◽

Cited By ~ 4

Author(s):

B R Alkali ◽

M B Bello ◽

S Hussaini ◽

C O Onwuliri

Keyword(s):

Public Health ◽

Virus Infection ◽

Hepatitis E Virus ◽

Hepatitis E ◽

Serological Evidence ◽

Public Health Implication ◽

Health Implication

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Epidemiological study of hepatitis E virus infection in European wild boars (Sus scrofa) in Spain

Veterinary Microbiology ◽

10.1016/j.vetmic.2007.11.002 ◽

2008 ◽

Vol 129 (1-2) ◽

pp. 163-170 ◽

Cited By ~ 91

Author(s):

Nilsa de Deus ◽

Bibiana Peralta ◽

Sonia Pina ◽

Alberto Allepuz ◽

Enric Mateu ◽

...

Keyword(s):

Virus Infection ◽

Epidemiological Study ◽

Sus Scrofa ◽

Hepatitis E Virus ◽

Hepatitis E ◽

Wild Boars

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Serological evidence of Hepatitis E Virus infection in Antioquia, Colombia slaughtered pigs

Revista Mvz Córdoba ◽

10.21897/rmvz.63 ◽

2015 ◽

pp. 4602-4613 ◽

Cited By ~ 3

Author(s):

Jorge Forero D ◽

Cristian Gutiérrez V ◽

Jaime Parra S ◽

Guillermo Correa L ◽

Berardo Rodríguez ◽

...

Keyword(s):

Hepatitis E Virus ◽

Hepatitis E ◽

Igg Antibodies ◽

Serological Evidence ◽

Blood Samples ◽

Specific Antibodies ◽

Elisa Kit ◽

Igm Antibodies ◽

Slaughter Age ◽

Slaughtered Pigs

ABSTRACTObjective. To detect the presence of specific antibodies against Hepatitis E virus (HEV) in pigs slaughtered in Antioquia, the department where the greatest amount of pork is produced and consumed in Colombia. Materials and methods. Between September 2011 and May 2012, blood samples from pigs were obtained in five slaughterhouses of Antioquia, four of them located in the Aburrá Valley subregion and other located in northern subregión. Serum were evaluated with a commercial ELISA kit for diagnosing HEV in humans but adapted to detect IgG and IgM antibodies in pigs. Results. A 100.0% seropositivity for IgG antibodies was found in 1000 samples evaluated, and 82.06% for IgM antibodies were found in 740 samples. Conclusions. These results indicate that pigs in slaughter age in Antioquia, and possibly in Colombia, have been exposed to HEV at some point in their production process and a high percentage of them can arrive to slaughterhouses with recent infection.RESUMENObjetivo. Detectar la presencia de anticuerpos específicos contra el virus de la Hepatitis E (HEV) en cerdos faenados en Antioquia, departamento donde se produce y consume la mayor cantidad de carne de cerdo en Colombia. Materiales y métodos. Entre septiembre de 2011 y mayo de 2012, se obtuvieron muestras de sangre de cerdos en cinco plantas de faenado, cuatro de ellas ubicadas en el Valle de Aburrá y una en la subregión Norte del departamento de Antioquia, las cuales fueron evaluadas mediante un kit de ELISA comercial para diagnóstico de HEV en humanos pero adaptado para la detección de anticuerpos tipo IgG e IgM en cerdos. Resultados. Se encontró una seropositividad de 100.0% para anticuerpos tipo IgG en 1000 muestras evaluadas y de 82.06% para anticuerpos tipo IgM en 740 muestras. Una muestra de heces positiva para la detección del genoma HEV es similar al genotipo 3 encontrada en Estados Unidos. Conclusiones. Estos resultados indican que los cerdos en edad de faenado en Antioquia y posiblemente en Colombia, han tenido exposición a HEV del, un virus zoonótico emergente a nivel mundial, en algún momento de su proceso productivo.

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