scholarly journals Acute Pancreatitis as a Complication of Antiepileptic Treatment: Case Series and Review of the Literature

2021 ◽  
Vol 13 (1) ◽  
pp. 98-103
Author(s):  
Agnieszka Pawłowska-Kamieniak ◽  
Paulina Krawiec ◽  
Elżbieta Pac-Kożuchowska
Keyword(s):  
Valproic Acid ◽  
Acute Pancreatitis ◽  
Metabolic Disorders ◽  
Genetic Factors ◽  
Clinical Symptoms ◽  
Gallstone Disease ◽  
Young Patients ◽  
Case Series ◽  
Review Of The Literature ◽  
Acid Therapy

Acute pancreatitis (AP) appears to be rare disease in childhood. In children, it has a different aetiology and course, and requires different management than in adult patients. The diagnosis of AP is based on at least two of the three criteria, which include typical clinical symptoms, abnormalities in laboratory tests and/or imaging studies of the pancreas. There are many known causes leading to AP in children including infections, blunt abdominal trauma, genetic factors, gallstone disease, metabolic disorders, anatomical defects of the pancreas, systemic diseases, as well as drugs, including antiepileptic drugs, and especially preparations of valproic acid. In our study, we present four cases of young patients diagnosed with acute pancreatitis as a complication of valproic acid therapy and we present a review of the literature. We believe that the activity of pancreatic enzymes should be monitored in children treated with valproate preparations in the case of clinical symptoms suggesting AP.

Acute pancreatitis in children from Valproic acid: case series and review

2003 ◽  
Vol 28 (2) ◽  
pp. 145-148 ◽  
Author(s):  
Nancy L Grauso-Eby ◽  
Olga Goldfarb ◽  
Lori B Feldman-Winter ◽  
Gary N McAbee
Keyword(s):  
Valproic Acid ◽  
Acute Pancreatitis ◽  
Case Series

scholarly journals Acute pancreatitis and hyperammonemia in a hemodialysis patient during valproic acid therapy: A case report.

1994 ◽  
Vol 27 (1) ◽  
pp. 53-57 ◽  
Author(s):  
Toshiyuki Kamijo ◽  
Toshikazu Sato ◽  
Ryozo Yanagizawa ◽  
Hiroichi Kishi
Keyword(s):  
Valproic Acid ◽  
Acute Pancreatitis ◽  
Case Report ◽  
Hemodialysis Patient ◽  
Acid Therapy ◽  
Valproic Acid Therapy

Surgical Clipping vs Endovascular Coiling for Newly Diagnosed and Recurrent Cerebral Aneurysms: an Update on the Current Literature. Single-Center Case Series

2018 ◽  
Vol 2 (1) ◽  
pp. 16-21
Author(s):  
F. Salle ◽  
A. Jaume ◽  
G. Castelluccio ◽  
E. Spagnuolo
Keyword(s):  
Intracranial Aneurysms ◽  
Young Patients ◽  
Case Series ◽  
Cerebral Aneurysms ◽  
Endovascular Coiling ◽  
Newly Diagnosed ◽  
Review Of The Literature ◽  
Surgical Experience ◽  
Surgical Clipping ◽  
The Ideal

Abstract The ideal treatment for intracranial aneurysms has been highly controversial in the last few decades. It is particularly difficult to decide between clipping vs. coiling when it comes to an aneurysm that has already been treated. The authors performed a review of the literature published in the last ten years amongst the main neurosurgical publications and make recommendations based on this evidence and the surgical experience of the eldest author of this paper (ES). A series of cases of recurrent, incompletely coiled aneurysms treated with surgery is presented. Conclusions: aneurysms with a convenient configuration and location for either clipping or coiling might be better managed by surgical clipping in young patients considering that this treatment achieves higher rates of occlusion with a lower incidence of rebleeding. In elderly patients, each case must be discussed.

scholarly journals Levocarnitine for valproate-induced hyperammonemia in the psychiatric setting: A case series and literature review

2018 ◽  
Vol 8 (3) ◽  
pp. 148-154 ◽  
Author(s):  
Lauren M. Brown ◽  
Nicole Cupples ◽  
Troy A. Moore
Keyword(s):  
Valproic Acid ◽  
Literature Review ◽  
Psychiatric Disorders ◽  
Clinical Symptoms ◽  
Active Form ◽  
Case Series ◽  
Altered Mental Status ◽  
Carnitine Deficiency ◽  
Psychiatric Setting ◽  
Asymptomatic Patients

Abstract Introduction: Hyperammonemia is a potential adverse effect of valproic acid (VPA) therapy, which is often asymptomatic but can lead to severe, life-threatening encephalopathy. Carnitine deficiency due to VPA is the proposed mechanism for hyperammonemia and the development of VPA-induced hyperammonemic encephalopathy (VHE). Levocarnitine, the active form of carnitine, has been suggested for treatment and prevention of VHE. Methods: Data was collected by chart review of 3 patients who received oral levocarnitine supplementation in the psychiatric setting for VPA-induced hyperammonemia. Review of the literature was performed through June 2017 using the following PubMed search terms: valproate, valproic acid, hyperammonemia, altered mental status, encephalopathy, and levocarnitine. Articles were included if they described use of levocarnitine in VPA-treated patients with psychiatric disorders. Results: One patient developed encephalopathy with resolution of symptoms after VPA discontinuation. Valproic acid was restarted with the addition of levocarnitine to prevent VHE reoccurrence. In the other 2 cases, levocarnitine was started prophylactically in patients who developed hyperammonemia without emergence of any clinical symptoms. Ammonia levels were reduced to normal in all cases, and no symptoms consistent with encephalopathy were reported. The literature search identified 6 additional cases with 5 of 6 reports supporting use of levocarnitine for decreased ammonia levels as well as an observational trial. Discussion: This literature review and case series illustrates successful use of levocarnitine supplementation for reduction of ammonia levels in the setting of VPA-induced hyperammonemia among patients with psychiatric disorders. However, clinical significance of ammonia reduction in asymptomatic patients is difficult to determine.

Pancreatitis Associated with Valproic Acid Therapy

PEDIATRICS ◽  
1979 ◽  
Vol 64 (4) ◽  
pp. 520-522
Author(s):  
Paul B. Batalden ◽  
Bruce J. Van Dyne ◽  
James Cloyd
Keyword(s):  
Valproic Acid ◽  
Acute Pancreatitis ◽  
The Other ◽  
Acid Therapy ◽  
Valproic Acid Therapy

The development of acute pancreatitis in an 8-year-old boy being treated with valproic acid for simple absence spells is documented. A brief discussion of the other previously reported complications with valproic acid is included.

scholarly journals Severe/Extreme Hypertriglyceridemia and LDL Apheretic Treatment: Review of the Literature, Original Findings

Cholesterol ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Olga Diakoumakou ◽  
Georgios Hatzigeorgiou ◽  
Nikos Gontoras ◽  
Maria Boutsikou ◽  
Vana Kolovou ◽  
...  
Keyword(s):  
Metabolic Disorders ◽  
Genetic Factors ◽  
Genetic Disorder ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Premature Coronary Artery Disease ◽  
Review Of The Literature ◽  
Treatment Review ◽  
Artery Disease

Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings.

scholarly journals Valproic acid induced acute necrotizing pancreatitis

2015 ◽  
Vol 1 (2) ◽  
pp. 86-88
Author(s):  
Rabindra Gurung ◽  
Asish Subedi ◽  
Balkrishna Bhattarai
Keyword(s):  
Valproic Acid ◽  
Acute Pancreatitis ◽  
Computerized Tomography ◽  
Epigastric Pain ◽  
Necrotizing Pancreatitis ◽  
Gall Stone ◽  
Acute Necrotizing Pancreatitis ◽  
Nausea And Vomiting ◽  
Acid Therapy ◽  
Acute Necrotizing

Background: Valproic acid induced pancreatitis is a rare entity with an estimated incidence of one in 40000. Occurrence of acute necrotizing pancreatitis is even more uncommon with only very few cases being reported till date. We present a case of valproic acid associated acute necrotizing pancreatitis that complicated to develop pancreatic pseudo cyst.Case discussion: A 21-year-old male presented in our emergency room with sudden onset of severe epigastric pain along with nausea and vomiting. He gave history of having on valproic acid therapy for the last 13 months for seizure disorder. There was no history suggestive of gall stone disease, alcohol intake, hyperlipidemia, abdominal trauma or any surgical intervention. Clinical suspicion of acute pancreatitis was confirmed by revealing of necrotizing pancreatitis in contrast enhanced computerized tomography. Patient was admitted in the intensive care unit where valproic acid was stopped and phenytoin started. Clinical improvement was observed with conservative management while mild intermittent abdominal pain, nausea and vomiting persisted. Repeat computerized tomography done later revealed features of pancreatic pseudo cyst for which patient underwent definitive surgical management.Conclusions: Today, valproic acid is widely used for multiple disease conditions. Starting from 1979 till 2010, 107 cases of valproic acid induced acute pancreatitis have been reported. Acute pancreatitis is a serious condition with significant mortality despite optimal treatment. Unfortunately, it is underreported and underestimated especially following valproic acid use. Increasing frequency of valproic acid associated pancreatitis demands reconsideration of its use.Journal of Society of Anesthesiologists 2014 1(2): 86-88

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