scholarly journals Comparison of Five Oral Cannabidiol Preparations in Adult Humans: Pharmacokinetics, Body Composition, and Heart Rate Variability

2021 ◽  
Vol 14 (1) ◽  
pp. 35
Author(s):  
Natasha N. Bondareva Williams ◽  
Taylor Russell Ewell ◽  
Kieran Shay Struebin Abbotts ◽  
Kole Jerel Harms ◽  
Keith A. Woelfel ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Body Composition ◽  
Peak Concentration ◽  
Area Under The Curve ◽  
Peak Frequency ◽  
Fat Free Mass ◽  
Time To Peak ◽  
Adult Humans ◽  
The Relationship

Data supporting the physiological effects of cannabidiol (CBD) ingestion in humans are conflicting. Differences between CBD preparations and bioavailability may contribute to these discrepancies. Further, an influence of body composition on CBD bioavailability is feasible, but currently undocumented. The aims of this study were to: (1) compare the pharmacokinetics of five oral CBD preparations over 4 h; (2) examine the relationship between body composition and CBD pharmacokinetics; and, (3) explore the influence of CBD on heart rate variability. In total, five preparations of CBD, standardized to 30 mg, were orally administered to 15 healthy men and women (21–62 years) in a randomized, crossover design. Prior to and 60 min following CBD ingestion, heart rate variability was determined. Body composition was assessed using dual energy X-ray absorptiometry. Peak circulating CBD concentration, time to peak concentration, and area under the curve was superior in a preparation comprising 5% CBD concentration liquid. Fat free mass was a significant predictor (R2 = 0.365, p = 0.017) of time to peak concentration for this preparation. Several heart rate variability parameters, including peak frequency of the high frequency band, were favorably, but modestly modified following CBD ingestion. These data confirm an influence of CBD preparation and body composition on CBD bioavailability, and suggest that acute CBD ingestion may have a modest influence on autonomic regulation of heart rate.

Resting energy expenditure-fat-free mass relationship: new insights provided by body composition modeling

2000 ◽  
Vol 279 (3) ◽  
pp. E539-E545 ◽  
Author(s):  
Zimian Wang ◽  
Stanley Heshka ◽  
Dympna Gallagher ◽  
Carol N. Boozer ◽  
Donald P. Kotler ◽  
...  
Keyword(s):  
Body Composition ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Fat Free Mass ◽  
New Approach ◽  
Human Energy ◽  
Adult Humans ◽  
Quantitative Manner ◽  
The Relationship ◽  
Resting Energy

The relationship between resting energy expenditure (REE) and metabolically active fat-free mass (FFM) is a cornerstone in the study of physiological aspects of body weight regulation and human energy requirements. Important questions, however, remain unanswered regarding the observed linear REE-FFM association in adult humans. This led us to develop a series of REE-body composition models that provide insights into the widely used simple linear REE-FFM prediction model derived experimentally in adult humans. The new models suggest that the REE-FFM relationship in mammals as a whole is curvilinear, that a segment of this function within a FFM range characteristic of adult humans can be fit with a linear equation almost identical to that observed from a composite review of earlier human studies, and that mammals as a whole exhibit a decrease in the proportion of FFM as high metabolic rate organs with greater FFM. The present study thus provides a new approach for examining REE-FFM relationships, advances in a quantitative manner previously observed albeit incompletely formulated REE-body composition associations, and identifies areas in need of additional research.

The Relationship Between Mindfulness and Heart Rate Variability

2010 ◽  
Author(s):  
Erin V. Rodgers ◽  
Raymond Fleming ◽  
Aaryn R. Schuster
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
The Relationship

The Relationship between Heart Rate Variability and Metabolic Syndrome at a Rural Area

2004 ◽  
Vol 16 (4) ◽  
pp. 459
Author(s):  
Kyoung Bok Min ◽  
Jin Young Min ◽  
Kyung Hee Jung-Choi ◽  
Hyung Joon Jhun ◽  
Sung Il Cho ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Heart Rate ◽  
Heart Rate Variability ◽  
Rural Area ◽  
The Relationship

scholarly journals Indices of Heart Rate Variability and Performance During a Response-Conflict Task Are Differently Associated With ADHD and Autism

2021 ◽  
pp. 108705472097279
Author(s):  
Alessio Bellato ◽  
Iti Arora ◽  
Puja Kochhar ◽  
Chris Hollis ◽  
Madeleine J. Groom
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Sensory Information ◽  
Response Conflict ◽  
Mediation Model ◽  
Conflict Task ◽  
Accurate Performance ◽  
And Performance ◽  
Comorbid Adhd ◽  
The Relationship

We investigated autonomic arousal, attention and response conflict, in ADHD and autism. Heart rate variability (HRV), and behavioral/electrophysiological indices of performance, were recorded during a task with low and high levels of response conflict in 78 children/adolescents (7–15 years old) with ADHD, autism, comorbid ADHD+autism, or neurotypical. ANOVA models were used to investigate effects of ADHD and autism, while a mediation model was tested to clarify the relationship between ADHD and slower performance. Slower and less accurate performance characterized ADHD and autism; however, atypical electrophysiological indices differently characterized these conditions. The relationship between ADHD and slower task performance was mediated by reduced HRV in response to the cue stimulus. Autonomic hypo-arousal and difficulties in mobilizing energetic resources in response to sensory information (associated with ADHD), and atypical electrophysiological indices of information processing (associated with autism), might negatively affect cognitive performance in those with ADHD+autism.

scholarly journals The relationship between Gulf War Illness symptom severity and heart rate variability: A pilot study

Life Sciences ◽  
2021 ◽  
pp. 119663
Author(s):  
Kyle J. Jaquess ◽  
Nathaniel Allen ◽  
Timothy J. Chun ◽  
Lucas Crock ◽  
Alexander A. Zajdel ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Pilot Study ◽  
Symptom Severity ◽  
Gulf War ◽  
Gulf War Illness ◽  
The Relationship

scholarly journals The relationship between heart rate variability and inflammatory markers in cardiovascular diseases

2008 ◽  
Vol 33 (10) ◽  
pp. 1305-1312 ◽  
Author(s):  
Alexander Haensel ◽  
Paul J. Mills ◽  
Richard A. Nelesen ◽  
Michael G. Ziegler ◽  
Joel E. Dimsdale
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Cardiovascular Diseases ◽  
Inflammatory Markers ◽  
The Relationship

The relationship between phobic anxiety and 2-year readmission after Acute Coronary Syndrome: What is the role of heart rate variability?

2019 ◽  
Vol 247 ◽  
pp. 73-80 ◽  
Author(s):  
Adrienne O'Neil ◽  
C. Barr Taylor ◽  
David L. Hare ◽  
Emma Thomas ◽  
Samia R. Toukhsati ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Rate Variability ◽  
Acute Coronary Syndrome ◽  
Coronary Syndrome ◽  
Phobic Anxiety ◽  
The Relationship
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