scholarly journals Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?

2021 ◽  
Vol 14 (7) ◽  
pp. 627
Author(s):  
Annachiara D’Urso ◽  
Marcello Locatelli ◽  
Angela Tartaglia ◽  
Linda Molteni ◽  
Cristian D’Ovidio ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Minimally Invasive ◽  
Drug Monitoring ◽  
Sampling Technique ◽  
Capillary Blood ◽  
Therapeutic Drug ◽  
Sample Collection ◽  
Trained Personnel ◽  
Stability Data ◽  
Volumetric Absorptive Microsampling

Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. In recent years, a new volumetric absorptive microsampling technique using VAMS® technology and Mitra® devices, consisting of a sampling technique for the collection of fixed-volume capillary blood, was developed. These new devices provide a new home-sampling technique for whole blood that has been spread out to simplify sample collection from finger-pricks. This review is aimed to compare published articles concerning the application of VAMS® in epilepsy and to identify the strengths and improvement points for the TDM of antiseizure medications. VAMS® allowed a minimally invasive blood sampling even in the absence of trained personnel. Good stability data have indicated that storage and delivery can be facilitated only for specific ASMs. Trueness and precision parameters have been evaluated, and the hematocrit (HCT) effect was minimized.

scholarly journals A whole blood microsampling assay for vancomycin: development, validation and application for pediatric clinical study

Bioanalysis ◽  
2020 ◽  
Vol 12 (18) ◽  
pp. 1295-1310
Author(s):  
Ganesh S Moorthy ◽  
Kevin J Downes ◽  
Christina Vedar ◽  
Athena F Zuppa
Keyword(s):  
Clinical Study ◽  
Therapeutic Drug Monitoring ◽  
Clinical Research ◽  
Clinical Data ◽  
Drug Monitoring ◽  
Whole Blood ◽  
Therapeutic Drug ◽  
Human Whole Blood ◽  
Assay Conditions ◽  
Volumetric Absorptive Microsampling

Background: Vancomycin is a commonly used antibiotic, which requires therapeutic drug monitoring to ensure optimal treatment. Microsampling assays are attractive tools for pediatric clinical research and therapeutic drug monitoring. Results: A LC–MS/MS method for the quantification of vancomycin in human whole blood employing volumetric absorptive microsampling (VAMS®) devices (20 μl) was developed and validated. Vancomycin was stable in human whole blood VAMS under assay conditions. Stability for vancomycin was established for at least 160 days as dried microsamples at -78°C. Conclusion: This method is currently being utilized for the quantitation of vancomycin in whole blood VAMS for an ongoing pediatric clinical study and representative clinical data are reported.

scholarly journals Thread-Based Sensors

Proceedings ◽  
2020 ◽  
Vol 32 (1) ◽  
pp. 22
Author(s):  
Rachel Smith ◽  
Mona Sweilam ◽  
John Varcoe ◽  
Carol Crean
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Minimally Invasive ◽  
Chemical Sensors ◽  
Drug Monitoring ◽  
Physiological Condition ◽  
Ph Monitoring ◽  
Wound Care ◽  
Therapeutic Drug ◽  
Invasive Monitoring ◽  
Fiber Architecture

Fiber and textile-based chemical sensors are emerging tools which target minimally invasive monitoring. Fiber-shaped electrodes are a versatile design for wearable applications since the fiber architecture allows for straightforward integration into textiles facilitating the principle of “wear-and-forget”. Skin and wound care would benefit from real-time pH monitoring, which can indicate wound health and the physiological condition of the skin. A further application of wearable chemical sensors is therapeutic drug monitoring.

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