scholarly journals Antidepressant Therapeutic Drug Monitoring by Minimally Invasive Techniques in Eating Disorders Patients: Preliminary Results from a Pilot Study with Focus on Vortioxetine

2020 ◽  
Vol 31 (5) ◽  
Author(s):  
Fabio Panariello
Keyword(s):  
Eating Disorders ◽  
Pilot Study ◽  
Therapeutic Drug Monitoring ◽  
Minimally Invasive ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Minimally Invasive Techniques ◽  
Preliminary Results ◽  
Invasive Techniques

Adherence with perindopril therapy: a pilot study using therapeutic drug monitoring of perindoprilat and an evaluation of the clearance estimation

2017 ◽  
Vol 39 (5) ◽  
pp. 1095-1100 ◽  
Author(s):  
Martin Šíma ◽  
Martin Vodička ◽  
Věra Marešová ◽  
Tomáš Šálek ◽  
Radomír Čabala ◽  
...  
Keyword(s):  
Pilot Study ◽  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Therapeutic Drug

scholarly journals Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?

2021 ◽  
Vol 14 (7) ◽  
pp. 627
Author(s):  
Annachiara D’Urso ◽  
Marcello Locatelli ◽  
Angela Tartaglia ◽  
Linda Molteni ◽  
Cristian D’Ovidio ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Minimally Invasive ◽  
Drug Monitoring ◽  
Sampling Technique ◽  
Capillary Blood ◽  
Therapeutic Drug ◽  
Sample Collection ◽  
Trained Personnel ◽  
Stability Data ◽  
Volumetric Absorptive Microsampling

Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. In recent years, a new volumetric absorptive microsampling technique using VAMS® technology and Mitra® devices, consisting of a sampling technique for the collection of fixed-volume capillary blood, was developed. These new devices provide a new home-sampling technique for whole blood that has been spread out to simplify sample collection from finger-pricks. This review is aimed to compare published articles concerning the application of VAMS® in epilepsy and to identify the strengths and improvement points for the TDM of antiseizure medications. VAMS® allowed a minimally invasive blood sampling even in the absence of trained personnel. Good stability data have indicated that storage and delivery can be facilitated only for specific ASMs. Trueness and precision parameters have been evaluated, and the hematocrit (HCT) effect was minimized.

scholarly journals The Possibility of Therapeutic Drug Monitoring of the Most Important Interactions in Nursing Homes

2019 ◽  
Vol 14 (2) ◽  
pp. 152-156 ◽  
Author(s):  
Pernille Schjøtt ◽  
Martina Šutovská ◽  
Jan Schjøtt
Keyword(s):  
Clinical Pharmacology ◽  
Pilot Study ◽  
Therapeutic Drug Monitoring ◽  
Nursing Homes ◽  
Elderly Patients ◽  
Drug Monitoring ◽  
Therapeutic Drug ◽  
Important Interaction ◽  
Potential Interactions ◽  
Recommended Action

Background:Therapeutic drug monitoring is a relevant tool in drug treatment of elderly patients. The aim of this study was to assess the possibility of therapeutic drug monitoring of the most important potential interactions in nursing homes.Methods:A material of prescribed drugs to 446 patients in three nursing homes in Bergen, Norway from a single day in March 2016 was analysed. Clinically relevant drug interactions (pharmacodynamic or pharmacokinetic) were identified and classified with Stockley`s Interaction Alerts. The most important interaction among several in each patient were ranked by recommended action > severity > evidence according to Stockley`s. The possibility of therapeutic drug monitoring of drug combinations involved in the most important interactions was retrieved from a database of all laboratories performing clinical pharmacology in Norway (the Pharmacology Portal).Results:Two or more drugs were used by 443 (99.3%) of 446 patients. Three-hundred and eightyfour patients (86.1%) had > 1 interaction. About 95% of the most important interactions were pharmacodynamic. In 280 (72.9%) of these interactions, Stockley`s recommended adjust dose or monitoring. Among the 384 most important interactions, 93% involved one drug and 41% involved two drugs available for therapeutic drug monitoring.Conclusion:In this pilot study, therapeutic drug monitoring was possible in the majority of the most important interactions in Norwegian nursing homes. This option is of importance since adjust dose or monitoring were frequently recommended actions associated with these interactions.

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