scholarly journals Therapeutic Drug Monitoring of Antidepressant by Minimally-Invasive Techniques in Eating Disorders Patients: A Clinical Research Report with A Focus on Vortioxetine

2021 ◽  
Vol 05 (03) ◽  
Author(s):  
Fabio Panariello ◽  
Tomas Mastellari ◽  
Angela di Gianni ◽  
Francesco Fornasari ◽  
Gianluca Borgiani ◽  
...  
Keyword(s):  
Eating Disorders ◽  
Therapeutic Drug Monitoring ◽  
Minimally Invasive ◽  
Clinical Research ◽  
Drug Monitoring ◽  
Research Report ◽  
Therapeutic Drug ◽  
Minimally Invasive Techniques ◽  
Invasive Techniques

scholarly journals Therapeutic Drug Monitoring of Antiseizure Medications Using Volumetric Absorptive Microsampling: Where Are We?

2021 ◽  
Vol 14 (7) ◽  
pp. 627
Author(s):  
Annachiara D’Urso ◽  
Marcello Locatelli ◽  
Angela Tartaglia ◽  
Linda Molteni ◽  
Cristian D’Ovidio ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Minimally Invasive ◽  
Drug Monitoring ◽  
Sampling Technique ◽  
Capillary Blood ◽  
Therapeutic Drug ◽  
Sample Collection ◽  
Trained Personnel ◽  
Stability Data ◽  
Volumetric Absorptive Microsampling

Therapeutic drug monitoring (TDM) of antiseizure medications (ASMs) represents a valuable tool to establish an appropriate patient therapy, to collect important information about drugs’ interactions and to evaluate patient’s metabolic capabilities. In recent years, a new volumetric absorptive microsampling technique using VAMS® technology and Mitra® devices, consisting of a sampling technique for the collection of fixed-volume capillary blood, was developed. These new devices provide a new home-sampling technique for whole blood that has been spread out to simplify sample collection from finger-pricks. This review is aimed to compare published articles concerning the application of VAMS® in epilepsy and to identify the strengths and improvement points for the TDM of antiseizure medications. VAMS® allowed a minimally invasive blood sampling even in the absence of trained personnel. Good stability data have indicated that storage and delivery can be facilitated only for specific ASMs. Trueness and precision parameters have been evaluated, and the hematocrit (HCT) effect was minimized.

scholarly journals A whole blood microsampling assay for vancomycin: development, validation and application for pediatric clinical study

Bioanalysis ◽  
2020 ◽  
Vol 12 (18) ◽  
pp. 1295-1310
Author(s):  
Ganesh S Moorthy ◽  
Kevin J Downes ◽  
Christina Vedar ◽  
Athena F Zuppa
Keyword(s):  
Clinical Study ◽  
Therapeutic Drug Monitoring ◽  
Clinical Research ◽  
Clinical Data ◽  
Drug Monitoring ◽  
Whole Blood ◽  
Therapeutic Drug ◽  
Human Whole Blood ◽  
Assay Conditions ◽  
Volumetric Absorptive Microsampling

Background: Vancomycin is a commonly used antibiotic, which requires therapeutic drug monitoring to ensure optimal treatment. Microsampling assays are attractive tools for pediatric clinical research and therapeutic drug monitoring. Results: A LC–MS/MS method for the quantification of vancomycin in human whole blood employing volumetric absorptive microsampling (VAMS®) devices (20 μl) was developed and validated. Vancomycin was stable in human whole blood VAMS under assay conditions. Stability for vancomycin was established for at least 160 days as dried microsamples at -78°C. Conclusion: This method is currently being utilized for the quantitation of vancomycin in whole blood VAMS for an ongoing pediatric clinical study and representative clinical data are reported.

scholarly journals Thread-Based Sensors

Proceedings ◽  
2020 ◽  
Vol 32 (1) ◽  
pp. 22
Author(s):  
Rachel Smith ◽  
Mona Sweilam ◽  
John Varcoe ◽  
Carol Crean
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Minimally Invasive ◽  
Chemical Sensors ◽  
Drug Monitoring ◽  
Physiological Condition ◽  
Ph Monitoring ◽  
Wound Care ◽  
Therapeutic Drug ◽  
Invasive Monitoring ◽  
Fiber Architecture

Fiber and textile-based chemical sensors are emerging tools which target minimally invasive monitoring. Fiber-shaped electrodes are a versatile design for wearable applications since the fiber architecture allows for straightforward integration into textiles facilitating the principle of “wear-and-forget”. Skin and wound care would benefit from real-time pH monitoring, which can indicate wound health and the physiological condition of the skin. A further application of wearable chemical sensors is therapeutic drug monitoring.

Therapeutic Drug Monitoring in Clinical Research

2008 ◽  
Vol 22 (4) ◽  
pp. 235-244 ◽  
Author(s):  
Cees Neef ◽  
Daniel J. Touw ◽  
Leo M. Stolk
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Clinical Research ◽  
Drug Monitoring ◽  
Therapeutic Drug

Diagnose und Monitoring bei chronisch-entzündlicher Darmerkrankung

2018 ◽  
Vol 75 (5) ◽  
pp. 316-328
Author(s):  
Christian Ansprenger ◽  
Emanuel Burri
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Morbus Crohn ◽  
Therapeutic Drug ◽  
Körperliche Untersuchung

Zusammenfassung. Die Diagnose und auch die Überwachung von chronisch entzündlichen Darmerkrankungen ruht auf mehreren Säulen: Anamnese, körperliche Untersuchung, Laborwerte (im Blut und Stuhl), Endoskopie, Histologie und Bildgebung. Die Diagnose kann nicht anhand eines einzelnen Befundes gestellt werden. In den letzten Jahren hat sich das Therapieziel weg von klinischen Endpunkten hin zu endoskopischen und sogar histologischen Endpunkten entwickelt. Für einige dieser neuen Therapieziele existiert allerdings noch keine allgemein gültige Definition. Regelmässige Endoskopien werden von Patienten schlecht toleriert, weshalb Surrogat-Marker wie Calprotectin untersucht wurden und eine gute Korrelation mit der mukosalen Entzündungsaktivität nachgewiesen werden konnte. Entsprechend zeigte sich bei Morbus Crohn eine Algorithmus-basierte Therapiesteuerung – unter anderem basierend auf Calprotectin – einer konventionellen Therapiesteuerung überlegen. Die Überwachung der medikamentösen Therapie («Therapeutic Drug Monitoring» [TDM]) ist ein zweites Standbein des Monitoring von chronisch entzündlichen Darmerkrankungen. Mit zunehmendem Einsatz vor allem der Biologika-Therapien wurden sowohl reaktives TDM (in Patienten mit klinischem Rezidiv) als auch proaktives TDM (in Patienten in Remission / stabiler Erkrankung) untersucht und haben (teilweise) Eingang in aktuelle Richtlinien gefunden. Zukünftige Studien werden die vorgeschlagenen Therapieziele besser definieren und den Nutzen der medikamentösen Therapieüberwachung auf den Krankheitsverlauf weiter untersuchen müssen.

Therapeutic drug monitoring (TDM) of the recent antipsychotic ziprasidone in dried blood spots (DBS) and plasma

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
L Mercolini ◽  
G Fulgenzi ◽  
M Melis ◽  
G Boncompagni ◽  
LJ Albers ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Drug Monitoring ◽  
Dried Blood Spots ◽  
Therapeutic Drug ◽  
Blood Spots

Comparison of CE and HPLC for therapeutic drug monitoring of the antiepileptic drug topiramate

2011 ◽  
Vol 44 (06) ◽  
Author(s):  
R Mandrioli ◽  
L Mercolini ◽  
N Ghedini ◽  
M Amore ◽  
E Kenndler ◽  
...  
Keyword(s):  
Therapeutic Drug Monitoring ◽  
Antiepileptic Drug ◽  
Drug Monitoring ◽  
Therapeutic Drug
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