scholarly journals Synthesis of Molecularly Imprinted Polymers for the Selective Extraction of Polymyxins from Environmental Water Samples

Polymers ◽  
2020 ◽  
Vol 12 (1) ◽  
pp. 131 ◽  
Author(s):  
Xuqin Song ◽  
Esther Turiel ◽  
Limin He ◽  
Antonio Martín-Esteban
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Water Samples ◽  
Solid Phase ◽  
Environmental Water ◽  
Resistant Bacteria ◽  
Colistin Resistance ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Relative Standard

The emergence of colistin resistance gen has aroused public concern. It is significant to assess the concentrations of polymyxins residues in aquatic environment since resistant bacteria carrying colistin resistance gen are frequently isolated from wastewater; surface water and ground water. However; no literature on the determination of polymyxins in water is available; probably due to the absence of an efficient extraction method. Accordingly; molecularly imprinted polymers were synthesized by precipitation polymerization with colistin as the template. The polymers were successfully used as sorbents for the determination of polymyxins from water based on molecularly imprinted solid-phase extraction and high-performance liquid chromatography–ultraviolet detection. The molecularly imprinted cartridge showed excellent affinity and cross-reactivity to analytes in aqueous media. Recoveries obtained from water samples were between 65.9% and 90.1%, with relative standard deviations lower than 10.2%. Limits of detection were between 1.0 and 2.0 μg L−1 concentration levels. Compared with C18 cartridge; the molecularly imprinted cartridge could remove more interference from co-extracted matrices. This method is practical for the routine monitoring of polymyxin residues in environmental water; which will benefit studies on drug-resistance and occurrence of polymyxins in the environment.

scholarly journals CONSTRUCTION OF A NEW ELECTROCHEMICAL SENSOR BASED ON A NEW MOLECULARLY IMPRINTED POLYMERS(MIPS) FOR HIGHLY SELECTIVE AND SENSITIVE DETERMINATION OF CLEBOPRIDE (CBD) IN PHARMACEUTICAL COMMERCIAL SAMPLES

2021 ◽  
Vol 52 (2) ◽  
pp. 367-376
Author(s):  
Y. K. Al-Bayati
Keyword(s):  
Ethylene Glycol ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Pharmaceutical Preparation ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Relative Standard ◽  
Sensitive Determination ◽  
Cross Linker

Clebopride (CBD) selective molecularly imprinted polymers(MIPs) were based on ion-pair by prepared four polymers(MIPs) using CBD as the template a well as (Acryl amide) (AAM), 2-Acrylamido-2-Methyl-1-Propane sulphonic Acid (2-AAMMPSA as monomer, used N,N-ethylenebismethacrylamide (EBMAA) ,ethylene glycol dimethacrylate ethylene glycol(EGDMAC), N, N-methylene bisacrylamide (NNMBAAM)) as cross linker and used benzoyl peroxide as initiator . NIPs prepared by using the same composition of MIPs except the template (CBD). The MIPs were prepared using variation  ratio of monomer and cross linker .These MIPs applicate as solid phase extraction for determination CBD in pharmaceutical preparation used UV as detector .the results gave good response, where the reconstruction percentage (Rec%) value of CBD drug took the range (99- 101% ), and the relative standard deviation (RSD%) value took the range (0.27% - 0.93 %) for standard solution and Rec% took values of (98- 99) %, and RSD% took values of (0.86 – 1.62) % of CBD drug for the Clebopride pharmaceutical.

Novel magnetic multi-template molecularly imprinted polymers for specific separation and determination of three endocrine disrupting compounds simultaneously in environmental water samples

RSC Advances ◽  
2014 ◽  
Vol 4 (100) ◽  
pp. 56798-56808 ◽  
Author(s):  
Ruixia Gao ◽  
Yi Hao ◽  
Siqi Zhao ◽  
Lili Zhang ◽  
Xihui Cui ◽  
...  
Keyword(s):  
Molecularly Imprinted Polymers ◽  
Water Samples ◽  
Endocrine Disrupting Compounds ◽  
Environmental Water ◽  
Environmental Water Samples ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Endocrine Disrupting

A novel type of superparamagnetic molecularly imprinted polymers introducing unique concept of multi-template for specific separation and determination of three endocrine disrupting compounds (EDCs) simultaneously.

scholarly journals Development of Surface Molecularly Imprinted Polymers as Dispersive Solid Phase Extraction Coupled with HPLC Method for the Removal and Detection of Griseofulvin in Surface Water

2019 ◽  
Vol 17 (1) ◽  
pp. 134 ◽  
Author(s):  
Kamran Bashir ◽  
Zhimin Luo ◽  
Guoning Chen ◽  
Hua Shu ◽  
Xia Cui ◽  
...  
Keyword(s):  
Surface Water ◽  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymers ◽  
Water Samples ◽  
Solid Phase ◽  
Phase Extraction ◽  
Dispersive Solid Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Surface Water Samples

Griseofulvin (GSF) is clinically employed to treat fungal infections in humans and animals. GSF was detected in surface waters as a pharmaceutical pollutant. GSF detection as an anthropogenic pollutant is considered as a possible source of drug resistance and risk factor in ecosystem. To address this concern, a new extraction and enrichment method was developed. GSF-surface molecularly imprinted polymers (GSF-SMIPs) were prepared and applied as solid phase extraction (SPE) sorbent. A dispersive solid phase extraction (DSPE) method was designed and combined with HPLC for the analysis of GSF in surface water samples. The performance of GSF-SMIPs was assessed for its potential to remove GSF from water samples. The factors affecting the removal efficiency such as sample pH and ionic strength were investigated and optimized. The DSPE conditions such as the amount of GSF-SMIPs, the extraction time, the type and volume of desorption solvents were also optimized. The established method is linear over the range of 0.1–100 µg/mL. The limits of detection and quantification were 0.01 and 0.03 µg/mL respectively. Good recoveries (91.6–98.8%) were achieved after DSPE. The intra-day and inter-day relative standard deviations were 0.8 and 4.3% respectively. The SMIPs demonstrated good removal efficiency (91.6%) as compared to powder activated carbon (67.7%). Moreover, the SMIPs can be reused 10 times for water samples. This is an additional advantage over single-use activated carbon and other commercial sorbents. This study provides a specific and sensitive method for the selective extraction and detection of GSF in surface water samples.

Determination of active ingredients in Chinese medicine Danning Tablets using dispersion solid-phase extraction by molecular imprinting nanomaterials coupled with HPLC-DAD

2017 ◽  
Vol 9 (17) ◽  
pp. 2585-2589 ◽  
Author(s):  
Jieping Luo ◽  
Ning Chen ◽  
Zaiyue Yang ◽  
Jiyong Han ◽  
Wanying Zhu ◽  
...  
Keyword(s):  
Solid Phase Extraction ◽  
Molecularly Imprinted Polymers ◽  
Solid Phase ◽  
Phase Extraction ◽  
Dispersive Solid Phase Extraction ◽  
Molecularly Imprinted ◽  
Imprinted Polymers ◽  
Pretreatment Method ◽  
Magnetic Molecularly Imprinted Polymers

A reliable pretreatment method of magnetic molecularly imprinted polymers/dispersive solid-phase extraction was developed for selectivity and enrichment of targets.

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