endocrine disrupting compounds
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Separations ◽  
2022 ◽  
Vol 9 (1) ◽  
pp. 19
Author(s):  
José Gustavo Ronderos-Lara ◽  
Hugo Saldarriaga-Noreña ◽  
Mario Alfonso Murillo-Tovar ◽  
Laura Alvarez ◽  
Josefina Vergara-Sánchez ◽  
...  

This study evaluated the distribution and potential estrogenic risk of the presence of bisphenol A (BPA), 4-nonylphenol (4NP), naproxen (NPX), ibuprofen (IBU), 17-β-estradiol (E2) and 17-α-ethinylestradiol (EE2) in water and sediments of the Apatlaco river micro-basin (Morelos, Mexico). The concentration of the determined compounds ranged between <LOD to 86.40 ng·L−1 and <LOD to 3.97 ng g−1 in water and sediments, respectively. The Log Kd distribution obtained (from 1.05 to 1.91 L Kg−1) indicates that the compounds tend to be adsorbed in sediments, which is probably due to the hydrophobic interactions confirmed by the significant correlations determined mainly between the concentrations and parameters of total organic carbon (TOC), total suspended solids (TSS), biological oxygen demand (BOD5) and chemical oxygen demand (COD). Of five sites analyzed, four presented estrogenic risk due to the analyzed endocrine-disrupting compounds (EEQE2 > 1 ng·L−1).


2021 ◽  
Vol 8 (4) ◽  
pp. 62-63
Author(s):  
Cristina Preda ◽  
◽  

Thyroid cancer has the highest prevalence of all endocrine malignancies, accounting for 1–3% of all human tumors. The incidence of differentiated thyroid cancer has increased globally in the last 10-20 years, faster than that of any other cancer type. The rising incidence has been observed in females, young adults, and children. The possible explanation might be the new achievements in diagnostic procedures, as thyroid ultrasonography and elastography, plus molecular testing and tumoral markers. Even though “over diagnosis” cannot be excluded, the increased incidence for all tumor sizes may suggest that other factors, such as lifestyle changes and environmental influences may contribute to a real increase.


Author(s):  
Jarosław Chmielewski ◽  
Jarosław Chmielewski ◽  
Barbara Gworek ◽  
Małgorzata Czarny-Działak ◽  
Izabela Wróblewska ◽  
...  

PLoS ONE ◽  
2021 ◽  
Vol 16 (12) ◽  
pp. e0259383
Author(s):  
Ekramy Halawa ◽  
Lamia Ryad ◽  
Nahla S. El-Shenawy ◽  
Rasha A. Al-Eisa ◽  
Heba N. Gad EL-Hak

Endocrine-disrupting compounds as pesticides affect the hormonal balance, and this can result in several diseases. Therefore, the analysis of representative hormones with acetamiprid (AC) and azoxystrobin (AZ) was a good strategy for the investigation of the endocrine-disrupting activity of pesticides. Hence, a sensitive and rapid analytical method using liquid chromatography-tandem mass spectrometry (LC-MS/MS) was developed. The method was validated for the analysis of AC, AZ, estriol, estrone, progesterone, and testosterone in the serum, testis, and liver of rats. The correlation between the residues of pesticides and the disturbance of the endocrine system was evaluated. The different mass parameters, mobile phase types, analytical columns, injection volumes, and extraction solvents were compared to get the lowest limit of detection of the studied compounds. The detection limits of AC, AZ, estriol, estrone, progesterone, and testosterone were 0.05, 0.05, 1.0, 10, and 1.0 ng/ml, respectively. The method developed was applied to evaluate the changes in these hormones induced by the duration of exposure to AC and AZ in rat testis and serum. The hormones level in rat serum and testis had a significant decrease as they were oral gavage treated with different high concentrations of studied pesticides. Both pesticides were distributed in the body of rats by the multi-compartment model (liver, testis, and serum).


2021 ◽  
pp. 129-151
Author(s):  
Gargi Sinha Sarkar ◽  
Aanchal Rathi ◽  
Soumen Basu ◽  
R. K. Arya ◽  
G. N. Halder ◽  
...  

Author(s):  
Sérgio Francisco de Aquino ◽  
Emanuel Manfred Freire Brandt ◽  
Sue Ellen Costa Bottrel ◽  
Fernanda Bento Rosa Gomes ◽  
Silvana de Queiroz Silva

The risks of pharmaceuticals and endocrine disrupting compounds (P&EDC) to the environment and human health are a current topic of interest. Hundreds of P&EDC may reach the environment, hence, there is a need to rank the level of concern of human exposure to these compounds. Thus, this work aimed at setting a priority list of P&EDC in Brazil, by studying their occurrence in raw and drinking water, calculating health guideline values (GV), and estimating the risks of population exposure to water intake. Data on the Brazilian pharmaceutical market as well as published data of the monitoring of Brazilian natural and drinking water have been collected by means of an exhaustive literature review. Furthermore, many foreign data were also collected to enable a comparison of the values found in Brazilian studies. A list of 55 P&EDC that have the potential to be found in Brazilian water is proposed, and for 41 of these a risk assessment was performed by estimating their margin of exposure (ME), by considering their occurrence in drinking water, and guideline values estimated from reported acceptable daily intake (ADI) data. For seven compounds the risk was deemed high (three estrogens and four anti-inflammatories), whereas for another seven compounds, it was regarded as an ‘alert’ situation. Although such risk analysis is conservative, since it has been calculated based on the highest reported P&EDC concentration in drinking water, it highlights the need to enhance their monitoring in Brazil to strengthen the database and support decision makers. An analysis of the occurrence of antimicrobial resistance agents (antibiotics, resistant bacteria, and resistance genes) in surface waters was also carried out and confirmed that such agents are present in water sources throughout Brazil, which deserves the attention of policy makers and health agents to prevent dissemination of antimicrobial resistance through water use.


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