scholarly journals IoT Application of Transfer Learning in Hybrid Artificial Intelligence Systems for Acute Lymphoblastic Leukemia Classification

Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 8025
Author(s):  
Krzysztof Pałczyński ◽  
Sandra Śmigiel ◽  
Marta Gackowska ◽  
Damian Ledziński ◽  
Sławomir Bujnowski ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Acute Lymphoblastic Leukemia ◽  
Network Architecture ◽  
Lymphoblastic Leukemia ◽  
White Blood Cells ◽  
Machine Learning Algorithms ◽  
Treatment Schedule ◽  
Correct Treatment ◽  
Hybrid Artificial Intelligence ◽  
Artificial Intelligence Systems

Acute lymphoblastic leukemia is the most common cancer in children, and its diagnosis mainly includes microscopic blood tests of the bone marrow. Therefore, there is a need for a correct classification of white blood cells. The approach developed in this article is based on an optimized and small IoT-friendly neural network architecture. The application of learning transfer in hybrid artificial intelligence systems is offered. The hybrid system consisted of a MobileNet v2 encoder pre-trained on the ImageNet dataset and machine learning algorithms performing the role of the head. These were the XGBoost, Random Forest, and Decision Tree algorithms. In this work, the average accuracy was over 90%, reaching 97.4%. This work proves that using hybrid artificial intelligence systems for tasks with a low computational complexity of the processing units demonstrates a high classification accuracy. The methods used in this study, confirmed by the promising results, can be an effective tool in diagnosing other blood diseases, facilitating the work of a network of medical institutions to carry out the correct treatment schedule.

scholarly journals Study of Some Biochemical Parameters in Iraqi Children with Acute Lymphoblastic Leukemia

2015 ◽  
Vol 12 (2) ◽  
pp. 371-378
Author(s):  
Baghdad Science Journal
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Biochemical Parameters ◽  
Serum Proteins ◽  
Lymphoblastic Leukemia ◽  
White Blood Cells ◽  
Total Serum ◽  
Childhood All ◽  
Marrow Cavity ◽  
Increased Risk

Leukemia or cancer of the blood is the most common childhood cancer, Acute lymphoblastic leukemia (ALL), is the most common form of leukemia that occurs in children. It is characterized by the presence of too many immature white blood cells in the child’s blood and bone marrow, Acute lymphoblastic leukemia can occur in adults too, treatment is different for children. Children with ALL develop symptoms related to infiltration of blasts in the bone marrow, lymphoid system, and extramedullary sites, such as the central nervous system (CNS). Common constitutional indications consist of fatigue (50%), pallor (25%), fever (60%), and weight loss (26%). Infiltration of blast cells in the marrow cavity and periosteum often lead to bone pain (23%) and disturbance of normal hematopoiesis. Thrombocytopenia with platelet counts less than 100,000 are seen in approximately 75% of patients. About 40% of patients with childhood ALL present with hemoglobin levels less than 7 g/dL. Although leukocyte counts greater than 50,000/mm3 occur in 20% of cases, neutropenia defined as an absolute neutrophil count less than 500 is common at presentation and is associated with an increased risk of infection. The aim of this study was to investigate the differentiations in some biochemical parameters (Hb, PCV, total serum proteins Aspartate amino transferase(AST), Alanin amino transferase (ALT), and Malondialdehyde (MDA) in blood which can be conceder as a marker of ALL. Samples were collected from 50 patients (between 1-16 years old) diagnosed with ALL after one month treatment with induction therapy, compared with 30 control samples taken from healthy persons at the same age . The ALT and MDA showed a significant increase p < 0.001 and p

Special issue on Hybrid Artificial Intelligence Systems from HAIS 2016 Conference

2019 ◽  
Vol 353 ◽  
pp. 1-2
Author(s):  
Francisco Martínez-Álvarez ◽  
Alicia Troncoso ◽  
Héctor Quintián ◽  
Emilio Corchado
Keyword(s):  
Artificial Intelligence ◽  
Special Issue ◽  
Hybrid Artificial Intelligence ◽  
Artificial Intelligence Systems

Special issue HAIS 2015: Recent advancements in hybrid artificial intelligence systems and its application to real-world problems

2019 ◽  
Vol 326-327 ◽  
pp. 69-70
Author(s):  
Pablo García Bringas ◽  
Igor Santos ◽  
Enrique Onieva ◽  
Eneko Osaba ◽  
Héctor Quintián ◽  
...  
Keyword(s):  
Artificial Intelligence ◽  
Real World ◽  
Special Issue ◽  
Hybrid Artificial Intelligence ◽  
Artificial Intelligence Systems ◽  
Real World Problems

Varicella Vaccine (VarilRix) in Children with Acute Lymphoblastic Leukemia.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 4436-4436
Author(s):  
Teresa Jackowska Ass ◽  
Robert Wasilewski ◽  
Elzbieta Górska ◽  
Maria Wasik ◽  
Teresa Loch
Keyword(s):  
Acute Lymphoblastic Leukemia ◽  
B Lymphocytes ◽  
Lymphoblastic Leukemia ◽  
Varicella Vaccine ◽  
White Blood Cells ◽  
Healthy Children ◽  
Varicella Zoster ◽  
Significant Difference ◽  
Before And After ◽  
History Of

Abstract Background: To assess the effectiveness of vaccination against varicella in children with acute lymphoblastic leukemia (ALL). Methods: 105 children without a history of varicella, were qualified for immunization against varicella with VARILRIX (Oka-strain varicella vaccine). 48 children had ALL and 57 were healthy. 25 of the children with ALL were receiving maintenance therapy, 23 children were after chemotherapy. Results: White blood cells (WBC), lymphocytes, and sub-populations of T- and B-lymphocytes were compared in the healthy and leukemic children before and after vaccination. The ALL children had significantly lower counts of WBC and lymphocytes before vaccination. After vaccination there were no significant differences in the counts of WBC in the healthy and leukemic children. However the ALL children had significantly lower mean counts of lymphocytes. Before vaccination the leukemic children showed a significantly lowered percentage of T-lymphocytes with decreased CD4+ and increased CD8+, what resulted in a lowered CD4 to CD8 ratio. After vaccination, only increased numbers of T CD8+ lymphocytes and a lowered CD4 to CD8 ratio were present while there was no significant difference in CD4. In the healthy and leukemic children alike there was no statistically significant difference between B-lymphocytes (CD 19+) and NK cells. In 10 children (20%), out of the 48 ALL vaccines, varicelliform rash occurred ~1 month after immunization. No adverse effects we observed in healthy children. Seroconversion to varicella-zoster virus was higher in healthy children and ALL children who had skin rash after vaccination. Two ALL children and three healthy ones had varicella one-two years after the vaccination. Those children received only single vaccine doses (double vaccine doses received children above 12 years). Conclusion: Varicella vaccine was safe and immunogenic in leukemic children during maintenance and after chemotherapy.

scholarly journals Multiple Osteolytic Lesions Causing Hypercalcemia: A Rare Presentation of Acute Lymphoblastic Leukemia

2017 ◽  
Vol 2017 ◽  
pp. 1-3 ◽  
Author(s):  
Khalid Mahmood ◽  
Muhammad Ubaid ◽  
Syeda Taliya Rizvi
Keyword(s):  
Bone Marrow ◽  
Acute Lymphoblastic Leukemia ◽  
Blood Cells ◽  
Hematological Malignancy ◽  
Lymphoblastic Leukemia ◽  
White Blood Cells ◽  
Peripheral Smear ◽  
Rare Presentation ◽  
Osteolytic Lesions ◽  
Severe Hypercalcemia

Acute lymphoblastic leukemia is characterized by unchecked proliferation of malignant lymphoblasts which replaces the normal bone marrow culminating in anemia due to red blood cells inadequacy as well as in easy bruising/bleeding secondary to insufficient platelets production. Even the white blood cells which are produced excessively are immature and abnormal. ALL is the most common hematological malignancy in children. Most commonly, patients present with lymphadenopathy, recurrent infections, bleeding, fatigue, and bone pains. Bone pains, often particularly involving long bones, occur in about 21–38% of cases and are due to overcrowding of bone marrow with malignant cells. Vast majority of children with ALL have thrombocytopenia and/or anemia with a normal or mildly elevated white blood cells count with the presence of lymphoblasts on peripheral smear. About 50% of children present with bleeding while about 75% of patients have platelet count 100,000/microL. Visceromegaly is not uncommon but osteolytic lesions and hypercalcemia are rather uncommon. We present a 22-year-old gentleman with generalized fatigue and bone pains without visceromegaly. There was severe hypercalcemia with normal parathyroid levels but multiple osteolytic lesions. Peripheral smear showed anemia without blasts, whereas a bone marrow biopsy revealed > 30% blasts with interspersed CD 10 positive cells.

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