scholarly journals Direct and Indirect Neurotoxic Potential of Metal/Metalloids in Plants and Fungi Used for Food, Dietary Supplements, and Herbal Medicine

Toxics ◽  
2021 ◽  
Vol 9 (3) ◽  
pp. 57
Author(s):  
Peter S. Spencer ◽  
Valerie S. Palmer

Plants and mushrooms bioconcentrate metals/metalloids from soil and water such that high levels of potentially neurotoxic elements can occur in cultivated and wild species used for food. While the health effects of excessive exposure to metals/metalloids with neurotoxic potential are well established, overt neurological disease from prolonged ingestion of contaminated botanicals has not been recognized. However, the presence of metal elements may affect levels of botanical neurotoxins in certain plants and mushrooms that are established causes of acute and chronic neurological disease.

2017 ◽  
Vol 7 (5) ◽  
pp. 646-652
Author(s):  
Sung A Cho ◽  
Hye Rim Kong ◽  
Jae Bum Jo ◽  
Joon Suk Oh ◽  
Hye Mi Lee ◽  
...  

2006 ◽  
Vol 54 (11) ◽  
pp. 1725-1735 ◽  
Author(s):  
Richard L. Nahin ◽  
Annette L. Fitzpatrick ◽  
Jeff D. Williamson ◽  
Gregory L. Burke ◽  
Steven T. DeKosky ◽  
...  

2021 ◽  
Vol 8 ◽  
Author(s):  
Sanem Hosbas Coskun ◽  
Stephen A. Wise ◽  
Adam J. Kuszak

Insufficient assessment of the identity and chemical composition of complex natural products, including botanicals, herbal remedies, and dietary supplements, hinders reproducible research and limits understanding mechanism(s) of action and health outcomes, which in turn impede improvements in clinical practice and advances in public health. This review describes available analytical resources and good methodological practices that support natural product characterization and strengthen the knowledge gained for designing and interpreting safety and efficacy investigations. The practice of validating analytical methods demonstrates that measurements of constituents of interest are reproducible and appropriate for the sample (e.g., plant material, phytochemical extract, and biological specimen). In particular, the utilization of matrix-based reference materials enables researchers to assess the accuracy, precision, and sensitivity of analytical measurements of natural product constituents, including dietary ingredients and their metabolites. Select case studies are presented where the careful application of these resources and practices has enhanced experimental rigor and benefited research on dietary supplement health effects.


Planta Medica ◽  
2016 ◽  
Vol 82 (14) ◽  
pp. 1225-1235 ◽  
Author(s):  
Iffat Parveen ◽  
Stefan Gafner ◽  
Natascha Techen ◽  
Susan Murch ◽  
Ikhlas Khan

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