Background:
Oleamide is an essential substance for human health. So, the plants with high oleamide content are great
sources for health care products.
Objective:
This study is conducted to investigate the quality of oleamide in plants and test the bioactivity in the selected two studied
species.
Methods:
The three Ipomoea and five Dillenia species including Ipomoea alba, Ipomoea aquatica and Ipomoea pes-caprae, and
Dillenia indica, Dillenia obovata, Dillenia ovata, Dillenia parviflora and Dillenia pentagyna were investigated for the quantity of
oleamide by high-performance liquid chromatography. The biological activity test was conducted on the powder formulation of the
chosen plants, Dillenia ovata and Dillenia parviflora at a ratio of 30:70, for anti-inflammatory activity ex vivo on a panel of molecular
targets through ion channel inhibition including voltage-gated sodium channel, voltage-gated potassium channel, and the cardiac ion
as human ether-a-go-go related gene.
Results:
The results showed that the leaf extracts of I. aquatica and D. ovata gave the highest and subsequent oleamide quantity following 7.52 and 5.17 mg/g. Out of the Dillenia formulation which contained various compounds, oleamide showed the highest percentages of inhibition at 8.0-20.0%, and 6.2-14.2% in voltage-gated sodium channel, and voltage-gated potassium channel which
had slightly lower values than the oleamide standard, and no effect as 0.0% value inhibition in the cardiac ion channel.
Conclusion:
The Dillenia formulation exhibits anti-inflammatory activity without affecting the heart. Accordingly, the three studied
Ipomoea and three studied Dillenia species may be used for the same activity as a single component or formulation with effective
solvent for disease treatments.
Conotoxins That Could Provide Analgesia through Voltage Gated Sodium Channel Inhibition
